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Protein

V-type ATP synthase beta chain

Gene

atpB

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

Enzyme regulationi

Stimulated by sulfite, ethanol, glycerol, magnesium and zinc ions.

pH dependencei

Optimum pH is 5.2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Protein family/group databases

TCDBi3.A.2.3.1. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase beta chain
Alternative name(s):
V-ATPase subunit B
Gene namesi
Name:atpB
Synonyms:ahaB
Ordered Locus Names:MM_0779
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001446571 – 460V-type ATP synthase beta chainAdd BLAST460

Interactioni

Subunit structurei

Composed of seven subunits; A, B, C, D, E, F and G.

Protein-protein interaction databases

STRINGi192952.MM_0779.

Structurei

Secondary structure

1460
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 19Combined sources5
Beta strandi29 – 33Combined sources5
Beta strandi35 – 37Combined sources3
Beta strandi39 – 47Combined sources9
Beta strandi49 – 56Combined sources8
Beta strandi58 – 60Combined sources3
Beta strandi72 – 75Combined sources4
Beta strandi77 – 80Combined sources4
Helixi82 – 84Combined sources3
Beta strandi88 – 90Combined sources3
Beta strandi91 – 93Combined sources3
Beta strandi95 – 98Combined sources4
Beta strandi105 – 112Combined sources8
Turni113 – 115Combined sources3
Beta strandi124 – 126Combined sources3
Helixi132 – 135Combined sources4
Beta strandi148 – 150Combined sources3
Helixi156 – 166Combined sources11
Beta strandi170 – 174Combined sources5
Beta strandi176 – 185Combined sources10
Helixi187 – 200Combined sources14
Helixi202 – 205Combined sources4
Beta strandi206 – 212Combined sources7
Helixi217 – 238Combined sources22
Beta strandi241 – 247Combined sources7
Helixi249 – 256Combined sources8
Helixi260 – 262Combined sources3
Helixi275 – 284Combined sources10
Beta strandi288 – 290Combined sources3
Beta strandi296 – 304Combined sources9
Turni309 – 311Combined sources3
Helixi318 – 321Combined sources4
Beta strandi324 – 328Combined sources5
Helixi330 – 334Combined sources5
Turni343 – 345Combined sources3
Helixi351 – 353Combined sources3
Turni357 – 359Combined sources3
Helixi364 – 388Combined sources25
Helixi390 – 392Combined sources3
Helixi395 – 410Combined sources16
Helixi422 – 433Combined sources12
Helixi438 – 440Combined sources3
Helixi446 – 452Combined sources7
Turni454 – 456Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C61X-ray1.50A/B1-460[»]
2RKWX-ray2.81A/B1-460[»]
3B2QX-ray2.10A/B1-460[»]
3DSRX-ray2.70A/B1-460[»]
3EIUX-ray3.43A/B1-460[»]
3SSAX-ray1.70A/B1-460[»]
3TGWX-ray1.75A/B1-460[»]
3TIVX-ray1.75A/B1-460[»]
ProteinModelPortaliQ60187.
SMRiQ60187.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60187.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiarCOG00865. Archaea.
COG1156. LUCA.
HOGENOMiHOG000165320.
KOiK02118.
OMAiNEEAQYF.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00310. ATP_synth_B_arch. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR005724. ATPase_A1-cplx_bsu.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_bsu_C.
IPR027417. P-loop_NTPase.
IPR022879. V-ATPase_su_B/beta.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039114. V-ATPsynth_beta/V-ATPase_B. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01041. ATP_syn_B_arch. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60187-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEYKTITQ IAGPLIFVEK TEPVGYNEIV NIKMGDGTVR RGQVLDSSAD
60 70 80 90 100
IVVVQVFEGT GGLDKDCGVI FTGETLKLPA SVDLLGRILS GSGEPRDGGP
110 120 130 140 150
RIVPDQLLDI NGAAMNPYAR LPPKDFIQTG ISTIDGTNTL VRGQKLPIFS
160 170 180 190 200
ASGLPHNEIA LQIARQASVP GSESAFAVVF AAMGITNEEA QYFMSDFEKT
210 220 230 240 250
GALERAVVFL NLADDPAVER IVTPRMALTA AEYLAYEHGM HVLVILTDIT
260 270 280 290 300
NYAEALRQMG AARNEVPGRR GYPGYMYTDL ATLYERAGIV KGAKGSVTQI
310 320 330 340 350
PILSMPGDDI THPIPDLSGY ITEGQIVVAR ELHRKGIYPP INVLPSLSRL
360 370 380 390 400
MNSGIGAGKT REDHKAVSDQ MYAGYAEGRD LRGLVAIVGK EALSERDTKF
410 420 430 440 450
LEFADLFEDK FVRQGRNENR TIEDTLEIGW QILTHLPENQ LGRIDNKYIQ
460
KYHPAHRKAK
Length:460
Mass (Da):50,282
Last modified:July 26, 2002 - v2
Checksum:i3A7E6BD8ECBB5A7F
GO

Sequence cautioni

The sequence AAM30475 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → V in AAC06376 (PubMed:8702544).Curated1
Sequence conflicti49 – 68ADIVV…DKDCG → LTLWLSRFSKVLVGLTRTAV in AAC06376 (PubMed:8702544).CuratedAdd BLAST20
Sequence conflicti90S → F in AAC06376 (PubMed:8702544).Curated1
Sequence conflicti215D → E in AAC06376 (PubMed:8702544).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47274 Genomic DNA. Translation: AAC06376.1.
AE008384 Genomic DNA. Translation: AAM30475.1. Different initiation.
PIRiT45108.
RefSeqiWP_015411348.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM30475; AAM30475; MM_0779.
GeneIDi24880418.
KEGGimma:MM_0779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47274 Genomic DNA. Translation: AAC06376.1.
AE008384 Genomic DNA. Translation: AAM30475.1. Different initiation.
PIRiT45108.
RefSeqiWP_015411348.1. NC_003901.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C61X-ray1.50A/B1-460[»]
2RKWX-ray2.81A/B1-460[»]
3B2QX-ray2.10A/B1-460[»]
3DSRX-ray2.70A/B1-460[»]
3EIUX-ray3.43A/B1-460[»]
3SSAX-ray1.70A/B1-460[»]
3TGWX-ray1.75A/B1-460[»]
3TIVX-ray1.75A/B1-460[»]
ProteinModelPortaliQ60187.
SMRiQ60187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi192952.MM_0779.

Protein family/group databases

TCDBi3.A.2.3.1. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM30475; AAM30475; MM_0779.
GeneIDi24880418.
KEGGimma:MM_0779.

Phylogenomic databases

eggNOGiarCOG00865. Archaea.
COG1156. LUCA.
HOGENOMiHOG000165320.
KOiK02118.
OMAiNEEAQYF.

Miscellaneous databases

EvolutionaryTraceiQ60187.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00310. ATP_synth_B_arch. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR005724. ATPase_A1-cplx_bsu.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_bsu_C.
IPR027417. P-loop_NTPase.
IPR022879. V-ATPase_su_B/beta.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039114. V-ATPsynth_beta/V-ATPase_B. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01041. ATP_syn_B_arch. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVATB_METMA
AccessioniPrimary (citable) accession number: Q60187
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 26, 2002
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.