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Q60182

- GLNA_METJA

UniProt

Q60182 - GLNA_METJA

Protein

Glutamine synthetase

Gene

glnA

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Short name:
    GS
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:MJ1346
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454Glutamine synthetasePRO_0000153204Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ1346.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60182.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    KOiK01915.
    OMAiLFHVDSE.
    PhylomeDBiQ60182.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60182-1 [UniParc]FASTAAdd to Basket

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    MHWGMEMNVE QAIEYVKKNN VKFIRFQFVD ILGFPKNVAY PVKAGEKGIE    50
    ELREIFENGV WFDGSSITGF VGIEESDMLL KPDLSTLSVL PWRPEEKSVA 100
    RVICDVYKDE KTPFEGDPRS RLKAILEELK KEMNGEYFVG PEPEFFLLKR 150
    DPHNPHRWVP ADDGGYFDVE PLDDAPDIRR DIVLALENLG FHVEASHHEV 200
    APGQHEVDFK FDNALKTADS VITFKMTIKN IAKKHGLKAT FMPKPFFGMN 250
    GNGMHCHQSV WFNGEPSFYD PEGPYNGLSE TCLSYIAGIL SHAKALVAIT 300
    NPTVNSYKRL VPGYEAPVNI AWANKNRSAI IRVPAARGKA TRIEFRAPDP 350
    TCNPYLAFAC MLAAGLDGIK KKMTAPEPVE RNIFKMSEEE KKQLGIESVP 400
    ANLAAALDEL ECDEVLQKAL GKHIYENYME IKRAEWDDFR TAVTDWETGK 450
    YLIY 454
    Length:454
    Mass (Da):51,399
    Last modified:November 1, 1997 - v1
    Checksum:i3222CBA464D18120
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99355.1.
    PIRiA64468.
    RefSeqiNP_248348.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB99355; AAB99355; MJ_1346.
    GeneIDi1452249.
    KEGGimja:MJ_1346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99355.1 .
    PIRi A64468.
    RefSeqi NP_248348.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q60182.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ1346.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB99355 ; AAB99355 ; MJ_1346 .
    GeneIDi 1452249.
    KEGGi mja:MJ_1346.

    Phylogenomic databases

    eggNOGi COG0174.
    KOi K01915.
    OMAi LFHVDSE.
    PhylomeDBi Q60182.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiGLNA_METJA
    AccessioniPrimary (citable) accession number: Q60182
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Lacks the tyrosine conserved in bacteria and other archaea, involved in feedback inhibition.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3