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Q60182 (GLNA_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

Short name=GS
EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase
Gene names
Name:glnA
Ordered Locus Names:MJ1346
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the glutamine synthetase family.

Caution

Lacks the tyrosine conserved in bacteria and other archaea, involved in feedback inhibition.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

nitrogen fixation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454Glutamine synthetase
PRO_0000153204

Sequences

Sequence LengthMass (Da)Tools
Q60182 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 3222CBA464D18120

FASTA45451,399
        10         20         30         40         50         60 
MHWGMEMNVE QAIEYVKKNN VKFIRFQFVD ILGFPKNVAY PVKAGEKGIE ELREIFENGV 

        70         80         90        100        110        120 
WFDGSSITGF VGIEESDMLL KPDLSTLSVL PWRPEEKSVA RVICDVYKDE KTPFEGDPRS 

       130        140        150        160        170        180 
RLKAILEELK KEMNGEYFVG PEPEFFLLKR DPHNPHRWVP ADDGGYFDVE PLDDAPDIRR 

       190        200        210        220        230        240 
DIVLALENLG FHVEASHHEV APGQHEVDFK FDNALKTADS VITFKMTIKN IAKKHGLKAT 

       250        260        270        280        290        300 
FMPKPFFGMN GNGMHCHQSV WFNGEPSFYD PEGPYNGLSE TCLSYIAGIL SHAKALVAIT 

       310        320        330        340        350        360 
NPTVNSYKRL VPGYEAPVNI AWANKNRSAI IRVPAARGKA TRIEFRAPDP TCNPYLAFAC 

       370        380        390        400        410        420 
MLAAGLDGIK KKMTAPEPVE RNIFKMSEEE KKQLGIESVP ANLAAALDEL ECDEVLQKAL 

       430        440        450 
GKHIYENYME IKRAEWDDFR TAVTDWETGK YLIY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB99355.1.
PIRA64468.
RefSeqNP_248348.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ60182.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ1346.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB99355; AAB99355; MJ_1346.
GeneID1452249.
KEGGmja:MJ_1346.

Phylogenomic databases

eggNOGCOG0174.
KOK01915.
OMALFHVDSE.
PhylomeDBQ60182.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
TIGRFAMsTIGR00653. GlnA. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_METJA
AccessionPrimary (citable) accession number: Q60182
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names