Reviewed,
UniProtKB/Swiss-Prot Q60178 (HEM2_METJA)
Last modified
November 3, 2009.
Version 56.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Delta-aminolevulinic acid dehydratase Short name=ALADH Short name=ALAD EC=4.2.1.24 Alternative name(s): Porphobilinogen synthase | ||||
| Gene names |
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| Organism | Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 2190 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus |
Protein attributes
| Sequence length | 335 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 2 5-aminolevulinate = porphobilinogen + 2 H2O. |
| Cofactor | Zinc By similarity. |
| Pathway | |
| Subunit structure | Homooctamer By similarity. |
| Sequence similarities | Belongs to the ALADH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Porphyrin biosynthesis |
| Ligand | Zinc |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | porphyrin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | porphobilinogen synthase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. Venter J.C.Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440. |
Cross-references
Sequence databases | |
|---|---|
| L77117 Genomic DNA. Translation: AAB98637.1. | |
| PIR | C64380. |
| RefSeq | NP_247627.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1E51 based on UniProtKB P13716. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1451509. |
| GenomeReviews | Gene locus MJ0643 in contig L77117_GR. |
| KEGG | mja:MJ0643. |
| NMPDR | fig|243232.1.peg.664. |
| TIGR | MJ0643. |
Phylogenomic databases | |
| HOGENOM | Q60178. |
| OMA | PELGVIT. |
Enzyme and pathway databases | |
| BioCyc | MJAN243232:MJ_0643-MON. |
| BRENDA | 4.2.1.24. 256362. |
Family and domain databases | |
| InterPro | IPR001731. 4pyrrol_synth_porphobiln_synth. IPR013785. Aldolase_TIM. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR11458. AlaD_dehydratase. 1 hit. |
| Pfam | PF00490. ALAD. 1 hit. [Graphical view] |
| PIRSF | PIRSF001415. Porphbilin_synth. 1 hit. |
| PRINTS | PR00144. DALDHYDRTASE. |
| ProDom | PD002304. AlaD_dehydratase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HEM2_METJA | ||||||||
| Accession | Primary (citable) accession number: Q60178 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Methanococcus jannaschii Methanococcus jannaschii: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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