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Q60153

- TCPA_VIBCH

UniProt

Q60153 - TCPA_VIBCH

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Protein

Toxin coregulated pilin

Gene
tcpA, VC_0828
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: TIGR

GO - Biological processi

  1. cell projection organization Source: TIGR
  2. pathogenesis Source: TIGR
Complete GO annotation...

Enzyme and pathway databases

BioCyciVCHO:VC0828-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin coregulated pilin
Alternative name(s):
Pilus colonization factor
Gene namesi
Name:tcpA
Ordered Locus Names:VC_0828
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Fimbrium By similarity

GO - Cellular componenti

  1. extracellular organelle Source: InterPro
  2. pilus Source: TIGR
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 2525Atypical leader peptidePRO_0000024190Add
BLAST
Chaini26 – 224199Toxin coregulated pilinPRO_0000024191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261N-methylmethionine By similarity
Disulfide bondi145 ↔ 211 By similarity

Keywords - PTMi

Disulfide bond, Methylation

Miscellaneous databases

PMAP-CutDBQ60153.

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0828.

Structurei

Secondary structure

1
224
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi56 – 7621
Turni77 – 793
Helixi88 – 10013
Helixi106 – 1094
Turni112 – 1143
Beta strandi115 – 1173
Beta strandi119 – 1257
Beta strandi128 – 14013
Helixi142 – 15211
Helixi153 – 1553
Beta strandi157 – 1648
Helixi169 – 1724
Turni175 – 1773
Helixi182 – 1843
Beta strandi186 – 1905
Helixi204 – 2096
Beta strandi213 – 2153
Beta strandi217 – 2237

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HRVX-ray1.50A/B54-224[»]
ProteinModelPortaliQ60153.
SMRiQ60153. Positions 54-224.

Miscellaneous databases

EvolutionaryTraceiQ60153.

Family & Domainsi

Domaini

The leader sequence region and some other sequence particularities suggest that TcpA may represent a novel class of pilin, and imply the existence of a novel signal peptidase.

Phylogenomic databases

eggNOGiCOG2165.
KOiK10930.
OMAiKMVENEY.
OrthoDBiEOG680X19.

Family and domain databases

InterProiIPR012902. N_methyl_site.
IPR010271. TcpA.
[Graphical view]
PfamiPF05946. TcpA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02532. IV_pilin_GFxxxE. 1 hit.
PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60153-1 [UniParc]FASTAAdd to Basket

« Hide

MQLLKQLFKK KFVKEEHDKK TGQEGMTLLE VIIVLGIMGV VSAGVVTLAQ    50
RAIDSQNMTK AAQNLNSVQI AMTQTYRSLG NYPATANANA ATQLANGLVS 100
LGKVSADEAK NPFTGTAMGI FSFPRNSAAN KAFAITVGGL TQAQCKTLVT 150
SVGDMFPFIN VKEGAFAAVA DLGDFETSVA DAATGAGVIK SIAPGSANLN 200
LTNITHVEKL CTGTAPFTVA FGNS 224
Length:224
Mass (Da):23,279
Last modified:November 1, 1996 - v1
Checksum:i7E871F63D52BC180
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74730 Genomic DNA. Translation: CAA52745.1.
U09807 Genomic DNA. Translation: AAA85786.1.
AE003852 Genomic DNA. Translation: AAF93991.1.
PIRiJC4719.
RefSeqiNP_230476.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93991; AAF93991; VC_0828.
GeneIDi2614495.
KEGGivch:VC0828.
PATRICi20080761. VBIVibCho83274_0789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74730 Genomic DNA. Translation: CAA52745.1 .
U09807 Genomic DNA. Translation: AAA85786.1 .
AE003852 Genomic DNA. Translation: AAF93991.1 .
PIRi JC4719.
RefSeqi NP_230476.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HRV X-ray 1.50 A/B 54-224 [» ]
ProteinModelPortali Q60153.
SMRi Q60153. Positions 54-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC0828.

Protocols and materials databases

DNASUi 2614495.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF93991 ; AAF93991 ; VC_0828 .
GeneIDi 2614495.
KEGGi vch:VC0828.
PATRICi 20080761. VBIVibCho83274_0789.

Phylogenomic databases

eggNOGi COG2165.
KOi K10930.
OMAi KMVENEY.
OrthoDBi EOG680X19.

Enzyme and pathway databases

BioCyci VCHO:VC0828-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q60153.
PMAP-CutDB Q60153.

Family and domain databases

InterProi IPR012902. N_methyl_site.
IPR010271. TcpA.
[Graphical view ]
Pfami PF05946. TcpA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02532. IV_pilin_GFxxxE. 1 hit.
PROSITEi PS00409. PROKAR_NTER_METHYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparison of the promoter proximal regions of the toxin-co-regulated tcp gene cluster in classical and El Tor strains of Vibrio cholerae O1."
    Ogierman M.A., Voss E., Meaney C., Faast R., Attridge S.R., Manning P.A.
    Gene 170:9-16(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: El Tor H1 / Serotype O1.
  2. "TcpA pilin sequences and colonization requirements for O1 and O139 Vibrio cholerae."
    Rhine J.A., Taylor R.K.
    Mol. Microbiol. 13:1013-1020(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: El Tor H1 / Serotype O1.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiTCPA_VIBCH
AccessioniPrimary (citable) accession number: Q60153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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