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Q60153

- TCPA_VIBCH

UniProt

Q60153 - TCPA_VIBCH

Protein

Toxin coregulated pilin

Gene

tcpA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: TIGR

    GO - Biological processi

    1. cell projection organization Source: TIGR
    2. pathogenesis Source: TIGR

    Enzyme and pathway databases

    BioCyciVCHO:VC0828-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toxin coregulated pilin
    Alternative name(s):
    Pilus colonization factor
    Gene namesi
    Name:tcpA
    Ordered Locus Names:VC_0828
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    Subcellular locationi

    Fimbrium By similarity

    GO - Cellular componenti

    1. extracellular organelle Source: InterPro
    2. pilus Source: TIGR

    Keywords - Cellular componenti

    Fimbrium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 2525Atypical leader peptidePRO_0000024190Add
    BLAST
    Chaini26 – 224199Toxin coregulated pilinPRO_0000024191Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261N-methylmethionineBy similarity
    Disulfide bondi145 ↔ 211By similarity

    Keywords - PTMi

    Disulfide bond, Methylation

    Miscellaneous databases

    PMAP-CutDBQ60153.

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC0828.

    Structurei

    Secondary structure

    1
    224
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi56 – 7621
    Turni77 – 793
    Helixi88 – 10013
    Helixi106 – 1094
    Turni112 – 1143
    Beta strandi115 – 1173
    Beta strandi119 – 1257
    Beta strandi128 – 14013
    Helixi142 – 15211
    Helixi153 – 1553
    Beta strandi157 – 1648
    Helixi169 – 1724
    Turni175 – 1773
    Helixi182 – 1843
    Beta strandi186 – 1905
    Helixi204 – 2096
    Beta strandi213 – 2153
    Beta strandi217 – 2237

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3HRVX-ray1.50A/B54-224[»]
    ProteinModelPortaliQ60153.
    SMRiQ60153. Positions 54-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ60153.

    Family & Domainsi

    Domaini

    The leader sequence region and some other sequence particularities suggest that TcpA may represent a novel class of pilin, and imply the existence of a novel signal peptidase.

    Phylogenomic databases

    eggNOGiCOG2165.
    KOiK10930.
    OMAiKMVENEY.
    OrthoDBiEOG680X19.

    Family and domain databases

    InterProiIPR012902. N_methyl_site.
    IPR010271. TcpA.
    [Graphical view]
    PfamiPF05946. TcpA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02532. IV_pilin_GFxxxE. 1 hit.
    PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60153-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLLKQLFKK KFVKEEHDKK TGQEGMTLLE VIIVLGIMGV VSAGVVTLAQ    50
    RAIDSQNMTK AAQNLNSVQI AMTQTYRSLG NYPATANANA ATQLANGLVS 100
    LGKVSADEAK NPFTGTAMGI FSFPRNSAAN KAFAITVGGL TQAQCKTLVT 150
    SVGDMFPFIN VKEGAFAAVA DLGDFETSVA DAATGAGVIK SIAPGSANLN 200
    LTNITHVEKL CTGTAPFTVA FGNS 224
    Length:224
    Mass (Da):23,279
    Last modified:November 1, 1996 - v1
    Checksum:i7E871F63D52BC180
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74730 Genomic DNA. Translation: CAA52745.1.
    U09807 Genomic DNA. Translation: AAA85786.1.
    AE003852 Genomic DNA. Translation: AAF93991.1.
    PIRiJC4719.
    RefSeqiNP_230476.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF93991; AAF93991; VC_0828.
    GeneIDi2614495.
    KEGGivch:VC0828.
    PATRICi20080761. VBIVibCho83274_0789.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74730 Genomic DNA. Translation: CAA52745.1 .
    U09807 Genomic DNA. Translation: AAA85786.1 .
    AE003852 Genomic DNA. Translation: AAF93991.1 .
    PIRi JC4719.
    RefSeqi NP_230476.1. NC_002505.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3HRV X-ray 1.50 A/B 54-224 [» ]
    ProteinModelPortali Q60153.
    SMRi Q60153. Positions 54-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC0828.

    Protocols and materials databases

    DNASUi 2614495.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF93991 ; AAF93991 ; VC_0828 .
    GeneIDi 2614495.
    KEGGi vch:VC0828.
    PATRICi 20080761. VBIVibCho83274_0789.

    Phylogenomic databases

    eggNOGi COG2165.
    KOi K10930.
    OMAi KMVENEY.
    OrthoDBi EOG680X19.

    Enzyme and pathway databases

    BioCyci VCHO:VC0828-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q60153.
    PMAP-CutDB Q60153.

    Family and domain databases

    InterProi IPR012902. N_methyl_site.
    IPR010271. TcpA.
    [Graphical view ]
    Pfami PF05946. TcpA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02532. IV_pilin_GFxxxE. 1 hit.
    PROSITEi PS00409. PROKAR_NTER_METHYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the promoter proximal regions of the toxin-co-regulated tcp gene cluster in classical and El Tor strains of Vibrio cholerae O1."
      Ogierman M.A., Voss E., Meaney C., Faast R., Attridge S.R., Manning P.A.
      Gene 170:9-16(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: El Tor H1 / Serotype O1.
    2. "TcpA pilin sequences and colonization requirements for O1 and O139 Vibrio cholerae."
      Rhine J.A., Taylor R.K.
      Mol. Microbiol. 13:1013-1020(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: El Tor H1 / Serotype O1.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiTCPA_VIBCH
    AccessioniPrimary (citable) accession number: Q60153
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3