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Q60151 (GSHR_STRTR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione reductase

Short name=GR
Short name=GRase
EC=1.8.1.7
Gene names
Name:gor
OrganismStreptococcus thermophilus
Taxonomic identifier1308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Maintains high levels of reduced glutathione in the cytosol By similarity.

Catalytic activity

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Miscellaneous

The active site is a redox-active disulfide bond.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Glutathione reductase
PRO_0000067979

Regions

Nucleotide binding34 – 429FAD By similarity

Sites

Active site4391Proton acceptor By similarity

Amino acid modifications

Disulfide bond42 ↔ 47Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60151 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6A0DA46BEA828804

FASTA45048,712
        10         20         30         40         50         60 
MVKEYDYIVI GGGSGGIASA NRAAMHGAKV ILFEGKEVGG TCVNVGCVPK KVMWYGAQVA 

        70         80         90        100        110        120 
ETLHRYAGEY GFDVTINNFD FATLKANRQA YIDRIHGSFE RGFDSNGVER VYEYARFVDP 

       130        140        150        160        170        180 
HTVEVAGELY TAPHILIATG GHPLYPNIPG SEYGITSDGF FELDEVPKRT AVIGAGYIAV 

       190        200        210        220        230        240 
EVAGVLNALG SDTHLFVRKD RPLRTFDKDI IDVLVDEMAK SGPTLHMHAN ATEVVKNADD 

       250        260        270        280        290        300 
SLTISFDNEE TITVDCLIWA VGRAANTSGF GLEKTGVELT ERGNIYSDEF ENTSVPGIYA 

       310        320        330        340        350        360 
LGDVTGKLDL TPVAVKAGRQ LSERLFNNKV DAKLDYTDVA TVVFSHPAIG AIGLTEEKAI 

       370        380        390        400        410        420 
AKYGAENIKV YKSSFTPMYT ALGDNRQLST MKLVTLGEDE KIIGLHGIGY GVDEMIQGFS 

       430        440        450 
VAIKMGATKA DFDNTVAIHP TGSEEFVTMR 

« Hide

References

[1]"Characterization of the gor gene of the lactic acid bacterium Streptococcus thermophilus CNRZ368."
Pebay M., Holl A.-C., Simonet J.-M., Decaris B.
Res. Microbiol. 146:371-383(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CNRZ 368.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L27672 Genomic DNA. Translation: AAB00353.1.
Z29494 Genomic DNA. Translation: CAA82630.1.
PIRS41386.

3D structure databases

ProteinModelPortalQ60151.
SMRQ60151. Positions 3-450.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.390.30. 1 hit.
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. SSF55424. 1 hit.
TIGRFAMsTIGR01421. gluta_reduc_1. 1 hit.
PROSITEPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSHR_STRTR
AccessionPrimary (citable) accession number: Q60151
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families