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Q60106

- XANP_XANS2

UniProt

Q60106 - XANP_XANS2

Protein

Xanthomonalisin

Gene
N/A
Organism
Xanthomonas sp. (strain T-22)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Cleavage of casein.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei312 – 3121Charge relay systemBy similarity
    Active sitei316 – 3161Charge relay systemBy similarity
    Active sitei544 – 5441Charge relay systemBy similarity
    Metal bindingi585 – 5851CalciumBy similarity
    Metal bindingi586 – 5861Calcium; via carbonyl oxygenBy similarity
    Metal bindingi603 – 6031Calcium; via carbonyl oxygenBy similarity
    Metal bindingi605 – 6051CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    BRENDAi3.4.21.101. 6720.

    Protein family/group databases

    MEROPSiS53.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xanthomonalisin (EC:3.4.21.101)
    Alternative name(s):
    Carboxyl proteinase
    XCP
    Xanthomonapepsin
    Xanthomonas aspartic proteinase
    OrganismiXanthomonas sp. (strain T-22)
    Taxonomic identifieri136420 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 237214Removed in mature formPRO_0000027365Add
    BLAST
    Chaini238 – 635398XanthomonalisinPRO_0000027366Add
    BLAST
    Propeptidei636 – 827192Removed in mature formPRO_0000027367Add
    BLAST

    Post-translational modificationi

    Autocatalytically processed.

    Keywords - PTMi

    Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliQ60106.
    SMRiQ60106. Positions 241-625.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini241 – 625385Peptidase S53Add
    BLAST
    Domaini635 – 72288PKDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 peptidase S53 domain.Curated
    Contains 1 PKD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di2.60.40.670. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR007280. Peptidase_C_arc/bac.
    IPR015366. Peptidase_S53_propep.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR022409. PKD/Chitinase_dom.
    IPR000601. PKD_dom.
    IPR009020. Prot_inh_propept.
    [Graphical view]
    PfamiPF00801. PKD. 1 hit.
    PF04151. PPC. 1 hit.
    PF09286. Pro-kuma_activ. 1 hit.
    [Graphical view]
    SMARTiSM00089. PKD. 1 hit.
    SM00944. Pro-kuma_activ. 1 hit.
    [Graphical view]
    SUPFAMiSSF49299. SSF49299. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEiPS50093. PKD. 1 hit.
    PS51695. SEDOLISIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60106-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIEKTALTV AIALAMSSLS AHAEDAWVST HTQAAMSPPA STQVLAASST    50
    SATTTGNAYT LNMTGSPRID GAAVTALEAD HPLHVEVALK LRNPDALQTF 100
    LAGVTTPGSA LFGKFLTPSQ FTERFGPTQS QVDAVVAHLQ QAGFTNIEVA 150
    PNRLLISADG TAGAATNGFR TSIKRFSANG REFFANDAPA LVPASLGDSV 200
    NAVLGLQNVS VKHTLHHVYH PEDVTVPGPN VGTQAAAAVA AHHPQDFAAI 250
    YGGSSLPAAT NTAVGIITWG SITQTVTDLN SFTSGAGLAT VNSTITKVGS 300
    GTFANDPDSN GEWSLDSQDI VGIAGGVKQL IFYTSANGDS SSSGITDAGI 350
    TASYNRAVTD NIAKLINVSL GEDETAAQQS GTQAADDAIF QQAVAQGQTF 400
    SIASGDAGVY QWSTDPTSGS PGYVANSAGT VKIDLTHYSV SEPASSPYVI 450
    QVGGTTLSTS GTTWSGETVW NEGLSAIAPS QGDNNQRLWA TGGGVSLYEA 500
    APSWQSSVSS STKRVGPDLA FDAASSSGAL IVVNGSTEQV GGTSLASPLF 550
    VGAFARIESA ANNAIGFPAS KFYQAFPTQT SLLHDVTSGN NGYQSHGYTA 600
    ATGFDEATGF GSFDIGKLNT YAQANWVTGG GGGSTNAPPV ANFSVATTGL 650
    VATFTDSSTD SDGSIASHAW TFGDGSTSTA TSPSHTYSAA GTYSVAETVT 700
    DNAGATSTKT SSVTVSSSGG TGGGTVLQNG VAATGLSAAK NGQLKYTVAI 750
    PSGAKSLKIA ISGGTGDADL YVKFGSAPTT SSYDCRPYVT GNTESCSFAS 800
    PQTGTYYVLL NGYAAFSGVS LKATWTN 827
    Length:827
    Mass (Da):83,707
    Last modified:November 1, 1996 - v1
    Checksum:i21A33C4C683DBC8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83740 Genomic DNA. Translation: BAA12093.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83740 Genomic DNA. Translation: BAA12093.1 .

    3D structure databases

    ProteinModelPortali Q60106.
    SMRi Q60106. Positions 241-625.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S53.002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 3.4.21.101. 6720.

    Family and domain databases

    Gene3Di 2.60.40.670. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR007280. Peptidase_C_arc/bac.
    IPR015366. Peptidase_S53_propep.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR022409. PKD/Chitinase_dom.
    IPR000601. PKD_dom.
    IPR009020. Prot_inh_propept.
    [Graphical view ]
    Pfami PF00801. PKD. 1 hit.
    PF04151. PPC. 1 hit.
    PF09286. Pro-kuma_activ. 1 hit.
    [Graphical view ]
    SMARTi SM00089. PKD. 1 hit.
    SM00944. Pro-kuma_activ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49299. SSF49299. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEi PS50093. PKD. 1 hit.
    PS51695. SEDOLISIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of an isovaleryl pepstatin-insensitive carboxyl proteinase gene from Xanthomonas sp. T-22."
      Oda K., Ito M., Uchida K., Shibano Y., Fukuhara K., Takahashi S.
      J. Biochem. 120:564-572(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    2. "Identification of catalytic residues of pepstatin-insensitive carboxyl proteinases from prokaryotes by site-directed mutagenesis."
      Oyama H., Abe S., Ushiyama S., Takahashi S., Oda K.
      J. Biol. Chem. 274:27815-27822(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ASPARTIC ACID AND GLUTAMIC ACID RESIDUES, ACTIVE SITES.

    Entry informationi

    Entry nameiXANP_XANS2
    AccessioniPrimary (citable) accession number: Q60106
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3