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Q600J2

- TRMB_MYCH2

UniProt

Q600J2 - TRMB_MYCH2

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, mhp463
Organism
Mycoplasma hyopneumoniae (strain 232)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331S-adenosyl-L-methionine By similarity
Binding sitei58 – 581S-adenosyl-L-methionine By similarity
Binding sitei85 – 851S-adenosyl-L-methionine By similarity
Active sitei106 – 1061 By similarity
Binding sitei106 – 1061S-adenosyl-L-methionine By similarity
Binding sitei110 – 1101Substrate By similarity
Binding sitei142 – 1421Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMHYO295358:GH8B-488-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:mhp463
OrganismiMycoplasma hyopneumoniae (strain 232)
Taxonomic identifieri295358 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000006822: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171353Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi295358.mhp463.

Structurei

3D structure databases

ProteinModelPortaliQ600J2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 1834Substrate binding Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q600J2-1 [UniParc]FASTAAdd to Basket

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MRLRNIPDAL ERIQNQNLLV KTPWNIDDSW IIEIGMGKGK MISQLAFDNP    50
NKNFLGVEKY PSAAVKSIKY VKKYNLSNFF ILISDAKDLL DQIKGKASTI 100
WLTFPDPWPK NRHYKRRLTY KDFLKIYANL LVKDGILKLK TDNLKFFEFS 150
IESLKENGWK ITYQTNDLHN SLVNSSNIKT TYEEKWVNLN YKIHYLEAIF 200
I 201
Length:201
Mass (Da):23,700
Last modified:November 23, 2004 - v1
Checksum:i543FDC3C06B79D70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017332 Genomic DNA. Translation: AAV27897.1.
RefSeqiYP_115973.1. NC_006360.1.

Genome annotation databases

EnsemblBacteriaiAAV27897; AAV27897; mhp463.
GeneIDi3105391.
KEGGimhy:mhp463.
PATRICi20011599. VBIMycHyo77580_0503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017332 Genomic DNA. Translation: AAV27897.1 .
RefSeqi YP_115973.1. NC_006360.1.

3D structure databases

ProteinModelPortali Q600J2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 295358.mhp463.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV27897 ; AAV27897 ; mhp463 .
GeneIDi 3105391.
KEGGi mhy:mhp463.
PATRICi 20011599. VBIMycHyo77580_0503.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MHYO295358:GH8B-488-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis."
    Minion F.C., Lefkowitz E.J., Madsen M.L., Cleary B.J., Swartzell S.M., Mahairas G.G.
    J. Bacteriol. 186:7123-7133(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 232.

Entry informationi

Entry nameiTRMB_MYCH2
AccessioniPrimary (citable) accession number: Q600J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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