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Q600A8 (G6PI_MYCH2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:mhp548
OrganismMycoplasma hyopneumoniae (strain 232) [Complete proteome] [HAMAP]
Taxonomic identifier295358 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180680

Sites

Active site2821Proton donor By similarity
Active site3031 By similarity
Active site4181 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q600A8 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 62EAFB3E2C9ADABE

FASTA42948,598
        10         20         30         40         50         60 
MSLKLEVKTE IKLDYQDFQN QINEFHKRIN DKNSPDIIFL GWNNFPEVAI NPQEIARMRK 

        70         80         90        100        110        120 
IVENLHQNSI NVLVVIGIGG SYLGAKAALD FILGLGPFEN KPEVIFLGNS LSSTDLYQKI 

       130        140        150        160        170        180 
EYLKTKNFAI NVISKSGSTI EPAITFQILY QFLIDQIGEK LAKTRTFVTT SIKSGELLEI 

       190        200        210        220        230        240 
AKSNELEIFE VIESIGGRFS VLSSVGFFPL LFAKINVDEI IQGAIKAHKK YSTSSISQNL 

       250        260        270        280        290        300 
AYKYALFRFL MYKNFNYKTE ILISYEPFLI YFNEWWKQLF GESEGKNLKG LFPASAIFTT 

       310        320        330        340        350        360 
DLHSLGQFIQ DGSKNFFQTI IYIKKPKFDL GIKKLVQFNT KINKLSGKTV SEINFQAFLA 

       370        380        390        400        410        420 
TTLAHSSYGN NPNLVLEIAD SSPKTFGHLV MFFEKACAMS AYLLGVNPFD QPGVESYKNE 


LAKNLGWDR 

« Hide

References

[1]"The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis."
Minion F.C., Lefkowitz E.J., Madsen M.L., Cleary B.J., Swartzell S.M., Mahairas G.G.
J. Bacteriol. 186:7123-7133(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 232.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017332 Genomic DNA. Translation: AAV27948.1.
RefSeqYP_116057.1. NC_006360.1.

3D structure databases

ProteinModelPortalQ600A8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING295358.mhp548.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV27948; AAV27948; mhp548.
GeneID3105257.
KEGGmhy:mhp548.
PATRIC20011775. VBIMycHyo77580_0591.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000100403.
KOK01810.
OMAKVNMFAL.
OrthoDBEOG64R61J.
ProtClustDBPRK14097.

Enzyme and pathway databases

BioCycMHYO295358:GH8B-572-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_MYCH2
AccessionPrimary (citable) accession number: Q600A8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 23, 2004
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways