pgi

Functionⁱ

Catalytic activityⁱ

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

no protein annotated in this organism
Glucose-6-phosphate isomerase (pgi)
ATP-dependent 6-phosphofructokinase (pfkA)
no protein annotated in this organism

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	282	Proton donorUniRule annotation	1
Active siteⁱ	303	UniRule annotation	1
Active siteⁱ	418	UniRule annotation	1

GO - Molecular functionⁱ

glucose-6-phosphate isomerase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-KW
glycolytic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181.

UniPathwayⁱ

UPA00109; UER00181.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation) Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation
Gene namesⁱ	Name:pgiUniRule annotation Ordered Locus Names:mhp548
Organismⁱ	Mycoplasma hyopneumoniae (strain 232)
Taxonomic identifierⁱ	295358 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma hyopneumoniae
Proteomesⁱ	UP000006822 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00473

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000180680	1 – 429	Glucose-6-phosphate isomeraseAdd BLAST		429

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q600A8.
SMRⁱ	Q600A8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000100403.
KEGG Orthology (KO) More...KOⁱ	K01810.
OMAⁱ	SFIIPDD.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0EIM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015. SIS_PGI_1. 1 hit. cd05016. SIS_PGI_2. 1 hit.
HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	View protein in InterPro IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. IPR035476. SIS_PGI_1. IPR035482. SIS_PGI_2.
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342. PGI. 1 hit.
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q600A8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLKLEVKTE IKLDYQDFQN QINEFHKRIN DKNSPDIIFL GWNNFPEVAI 
        60         70         80         90        100
NPQEIARMRK IVENLHQNSI NVLVVIGIGG SYLGAKAALD FILGLGPFEN 
       110        120        130        140        150
KPEVIFLGNS LSSTDLYQKI EYLKTKNFAI NVISKSGSTI EPAITFQILY 
       160        170        180        190        200
QFLIDQIGEK LAKTRTFVTT SIKSGELLEI AKSNELEIFE VIESIGGRFS 
       210        220        230        240        250
VLSSVGFFPL LFAKINVDEI IQGAIKAHKK YSTSSISQNL AYKYALFRFL 
       260        270        280        290        300
MYKNFNYKTE ILISYEPFLI YFNEWWKQLF GESEGKNLKG LFPASAIFTT 
       310        320        330        340        350
DLHSLGQFIQ DGSKNFFQTI IYIKKPKFDL GIKKLVQFNT KINKLSGKTV 
       360        370        380        390        400
SEINFQAFLA TTLAHSSYGN NPNLVLEIAD SSPKTFGHLV MFFEKACAMS 
       410        420 
AYLLGVNPFD QPGVESYKNE LAKNLGWDR

Length:429

Mass (Da):48,598

Last modified:November 23, 2004 - v1

Checksum:ⁱ62EAFB3E2C9ADABE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017332 Genomic DNA. Translation: AAV27948.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011206381.1. NC_006360.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAV27948; AAV27948; mhp548.
KEGGⁱ	mhy:mhp548.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q600A8	Q4A9F3 Q4A7J2 A0A0T9WB74 E4QTJ0 UPI000332829A UPI0004166BD6 S5FY12 A0A0T9WB69	Mycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110) Mycoplasma hyopneumoniae (strain 232) Mycoplasma hyopneumoniae (strain 7448) Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 Mycoplasma hyopneumoniae (strain 168) Mycoplasma hyopneumoniae Mycoplasma hyopneumoniae 7422	429	UniRef90_Q4A9F3	Cluster: Glucose-6-phosphate isomerase	9

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q600A8	Q98R79 A0A0A8E6T3 F9QEH0 E0TLA0 K7X9E4 A0A0E9AZI5 C5J7D5 UPI0002DAB00C UPI0005C69A65 UPI00083E72B1 +21	Mycoplasma pulmonis (strain UAB CTIP) Mycoplasma flocculare ATCC 27399 Mycoplasma anatis 1340 Mycoplasma hyorhinis (strain HUB-1) Mycoplasma hyorhinis SK76 Chlamydia trachomatis Mycoplasma conjunctivae (strain ATCC 25834 / HRC/581 / NCTC 10147) Mycoplasma conjunctivae Mycoplasma ovipneumoniae Mycoplasma ovipneumoniae 14811 And more	427	UniRef50_Q98R79	Cluster: Glucose-6-phosphate isomerase	32

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017332 Genomic DNA. Translation: AAV27948.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011206381.1. NC_006360.1.

3D structure databases

ProteinModelPortalⁱ	Q600A8.
SMRⁱ	Q600A8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAV27948; AAV27948; mhp548.
KEGGⁱ	mhy:mhp548.

Phylogenomic databases

HOGENOMⁱ	HOG000100403.
KEGG Orthology (KO) More...KOⁱ	K01810.
OMAⁱ	SFIIPDD.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0EIM.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181.

UniPathwayⁱ

UPA00109; UER00181.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015. SIS_PGI_1. 1 hit. cd05016. SIS_PGI_2. 1 hit.
HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	View protein in InterPro IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. IPR035476. SIS_PGI_1. IPR035482. SIS_PGI_2.
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342. PGI. 1 hit.
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G6PI_MYCH2
Accessionⁱ	Q600A8Primary (citable) accession number: Q600A8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
	Last sequence update:	November 23, 2004
	Last modified:	August 30, 2017
	This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q600A8 (G6PI_MYCH2)

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Glucose-6-phosphate isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ