Q60080 (DHAS_VIBMI) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 65.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Aspartate-semialdehyde dehydrogenase Short name=ASA dehydrogenase Short name=ASADH EC=1.2.1.11 Alternative name(s): Aspartate-beta-semialdehyde dehydrogenase | ||
| Gene names |
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| Organism | Vibrio mimicus | ||
| Taxonomic identifier | 674 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio |
Protein attributes
| Sequence length | 316 AA. |
| Sequence status | Fragment. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate By similarity. HAMAP MF_02121 |
| Catalytic activity | L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH. HAMAP MF_02121 |
| Pathway | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4. HAMAP MF_02121 Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3. HAMAP MF_02121 Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5. HAMAP MF_02121 |
| Subunit structure | Homodimer By similarity. HAMAP MF_02121 |
| Sequence similarities | Belongs to the aspartate-semialdehyde dehydrogenase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – ›316 | ›316 | Aspartate-semialdehyde dehydrogenase HAMAP MF_02121 | PRO_0000141395 | |||||
Regions | |||||||||
| Nucleotide binding | 13 – 16 | 4 | NADP By similarity | ||||||
| Nucleotide binding | 41 – 42 | 2 | NADP By similarity | ||||||
| Nucleotide binding | 162 – 163 | 2 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 132 | 1 | Acyl-thioester intermediate By similarity | ||||||
| Active site | 245 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 101 | 1 | Phosphate By similarity | ||||||
| Binding site | 159 | 1 | Substrate By similarity | ||||||
| Binding site | 216 | 1 | Phosphate By similarity | ||||||
| Binding site | 238 | 1 | Substrate By similarity | ||||||
| Binding site | 316 | 1 | NADP By similarity | ||||||
Experimental info | |||||||||
| Non-terminal residue | 316 | 1 | |||||||
Sequences
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References
| [1] | "The sixth and seventh cholera pandemics are due to independent clones separately derived from environmental, nontoxigenic, non-O1 Vibrio cholerae." Karaolis D.K., Lan R., Reeves P.R. J. Bacteriol. 177:3191-3198(1995) [PubMed: 7768818] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: M547. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U25067 Genomic DNA. Translation: AAC43377.1. |
3D structure databases | |
| ProteinModelPortal | Q60080. |
| SMR | Q60080. Positions 2-316. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| HAMAP | MF_02121. ASADH. [Tree] |
| InterPro | IPR000319. Asp-semialdehyde_DH_CS. IPR012080. Asp_semialdehyde_DH. IPR005986. Asp_semialdehyde_DH_beta. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view] |
| PIRSF | PIRSF000148. ASA_dh. 1 hit. |
| SMART | SM00859. Semialdhyde_dh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01296. Asd_B. 1 hit. |
| PROSITE | PS01103. ASD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHAS_VIBMI | ||||||||
| Accession | Primary (citable) accession number: Q60080 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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