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Protein

Probable cadmium-transporting ATPase

Gene

cadA

Organism
Listeria monocytogenes
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism.

Catalytic activityi

ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi14CadmiumPROSITE-ProRule annotation1
Metal bindingi17CadmiumPROSITE-ProRule annotation1
Active sitei3984-aspartylphosphate intermediateCurated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antiport, Cadmium resistance, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Cadmium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.3. 3045.

Protein family/group databases

TCDBi3.A.3.6.8. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cadmium-transporting ATPase (EC:3.6.3.3)
Alternative name(s):
Cadmium efflux ATPase
Gene namesi
Name:cadA
Encoded oniPlasmid pLm740 Publication
OrganismiListeria monocytogenes
Taxonomic identifieri1639 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei669 – 689HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462471 – 711Probable cadmium-transporting ATPaseAdd BLAST711

Keywords - PTMi

Phosphoprotein

Structurei

Secondary structure

1711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Helixi15 – 27Combined sources13
Beta strandi31 – 36Combined sources6
Beta strandi39 – 48Combined sources10
Helixi51 – 58Combined sources8
Turni59 – 61Combined sources3
Beta strandi64 – 66Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AJ0NMR-A1-71[»]
2AJ1NMR-A1-71[»]
ProteinModelPortaliQ60048.
SMRiQ60048.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60048.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 67HMAPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKTVYRVD GLSCTNCAAK FERNVKEIEG VTEAIVNFGA SKITVTGEAS
60 70 80 90 100
IQQVEQAGAF EHLKIIPEKE SFTDPEHFTD HQSFIRKNWR LLLSGLFIAV
110 120 130 140 150
GYASQIMNGE DFYLTNALFI FAIFIGGYSL FKEGFKNLLK FEFTMETLMT
160 170 180 190 200
IAIIGAAFIG EWAEGSIVVI LFAVSEALER YSMDKARQSI RSLMDIAPKE
210 220 230 240 250
ALVRRSGTDR MVHVDDIQIG DIMIIKPGQK IAMDGHVVKG YSAVNQAAIT
260 270 280 290 300
GESIPVEKNI DDSVFAGTLN EEGLLEVAVT KRVEDTTISK IIHLVEEAQG
310 320 330 340 350
ERAPAQAFVD TFAKYYTPAI IVIAALIATV PPLLFGGNWE TWVYQGLSVL
360 370 380 390 400
VVGCPCALVV STPVAIVTAI GNAAKNGVLV KGGVYLEEIG GLKAIAFDKT
410 420 430 440 450
GTLTKGVPVV TDYIELTEAT NIQHNKNYII MAALEQLSQH PLASAIIKYG
460 470 480 490 500
ETREMDLTSI NVNDFTSITG KGIRGTVDGN TYYVGSPVLF KELLASQFTD
510 520 530 540 550
SIHRQVSDLQ LKGKTAMLFG TNQKLISIVA VADEVRSSSQ HVIKRLHELG
560 570 580 590 600
IEKTIMLTGD NQATAQAIGQ QVGVSEIEGE LMPQDKLDYI KQLKINFGKV
610 620 630 640 650
AMVGDGINDA PALAAATVGI AMGGAGTDTA IETADVALMG DDLQKLPFTV
660 670 680 690 700
KLSRKTLQII KQNITFSLVI KLIALLLVIP GWLTLWIAIM ADMGATLLVT
710
LNGLRLMKVK D
Length:711
Mass (Da):77,089
Last modified:November 1, 1996 - v1
Checksum:iC23BFEB7E20CFE9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28104 Genomic DNA. Translation: AAA25275.1.
RefSeqiWP_003728466.1. NZ_MDRC01000011.1.
YP_003728018.1. NC_014255.1.

Genome annotation databases

GeneIDi9350447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28104 Genomic DNA. Translation: AAA25275.1.
RefSeqiWP_003728466.1. NZ_MDRC01000011.1.
YP_003728018.1. NC_014255.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AJ0NMR-A1-71[»]
2AJ1NMR-A1-71[»]
ProteinModelPortaliQ60048.
SMRiQ60048.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi3.A.3.6.8. the p-type atpase (p-atpase) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9350447.

Enzyme and pathway databases

BRENDAi3.6.3.3. 3045.

Miscellaneous databases

EvolutionaryTraceiQ60048.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADA_LISMN
AccessioniPrimary (citable) accession number: Q60048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid, Transposable element

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.