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Protein

Probable cadmium-transporting ATPase

Gene

cadA

Organism
Listeria monocytogenes
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Couples the hydrolysis of ATP with the export of cadmium.By similarity

Catalytic activityi

ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi14CadmiumPROSITE-ProRule annotation1
Metal bindingi17CadmiumPROSITE-ProRule annotation1
Active sitei3984-aspartylphosphate intermediateCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCadmium resistance, Ion transport, Transport
LigandATP-binding, Cadmium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.3 3045

Protein family/group databases

TCDBi3.A.3.6.8 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cadmium-transporting ATPaseCurated (EC:3.6.3.3By similarity)
Alternative name(s):
Cadmium-efflux ATPaseBy similarity
Gene namesi
Name:cadA
Encoded oniPlasmid pLm740 Publication
OrganismiListeria monocytogenes
Taxonomic identifieri1639 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei669 – 689HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462471 – 711Probable cadmium-transporting ATPaseAdd BLAST711

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By cadmium.1 Publication

Structurei

Secondary structure

1711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Helixi15 – 27Combined sources13
Beta strandi31 – 36Combined sources6
Beta strandi39 – 48Combined sources10
Helixi51 – 58Combined sources8
Turni59 – 61Combined sources3
Beta strandi64 – 66Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AJ0NMR-A1-71[»]
2AJ1NMR-A1-71[»]
ProteinModelPortaliQ60048
SMRiQ60048
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60048

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 67HMAPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
PRINTSiPR00941 CDATPASE
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q60048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKTVYRVD GLSCTNCAAK FERNVKEIEG VTEAIVNFGA SKITVTGEAS
60 70 80 90 100
IQQVEQAGAF EHLKIIPEKE SFTDPEHFTD HQSFIRKNWR LLLSGLFIAV
110 120 130 140 150
GYASQIMNGE DFYLTNALFI FAIFIGGYSL FKEGFKNLLK FEFTMETLMT
160 170 180 190 200
IAIIGAAFIG EWAEGSIVVI LFAVSEALER YSMDKARQSI RSLMDIAPKE
210 220 230 240 250
ALVRRSGTDR MVHVDDIQIG DIMIIKPGQK IAMDGHVVKG YSAVNQAAIT
260 270 280 290 300
GESIPVEKNI DDSVFAGTLN EEGLLEVAVT KRVEDTTISK IIHLVEEAQG
310 320 330 340 350
ERAPAQAFVD TFAKYYTPAI IVIAALIATV PPLLFGGNWE TWVYQGLSVL
360 370 380 390 400
VVGCPCALVV STPVAIVTAI GNAAKNGVLV KGGVYLEEIG GLKAIAFDKT
410 420 430 440 450
GTLTKGVPVV TDYIELTEAT NIQHNKNYII MAALEQLSQH PLASAIIKYG
460 470 480 490 500
ETREMDLTSI NVNDFTSITG KGIRGTVDGN TYYVGSPVLF KELLASQFTD
510 520 530 540 550
SIHRQVSDLQ LKGKTAMLFG TNQKLISIVA VADEVRSSSQ HVIKRLHELG
560 570 580 590 600
IEKTIMLTGD NQATAQAIGQ QVGVSEIEGE LMPQDKLDYI KQLKINFGKV
610 620 630 640 650
AMVGDGINDA PALAAATVGI AMGGAGTDTA IETADVALMG DDLQKLPFTV
660 670 680 690 700
KLSRKTLQII KQNITFSLVI KLIALLLVIP GWLTLWIAIM ADMGATLLVT
710
LNGLRLMKVK D
Length:711
Mass (Da):77,089
Last modified:November 1, 1996 - v1
Checksum:iC23BFEB7E20CFE9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28104 Genomic DNA Translation: AAA25275.1
RefSeqiWP_003728466.1, NZ_PQHU01000011.1
YP_003728018.1, NC_014255.1

Genome annotation databases

GeneIDi9350447

Similar proteinsi

Entry informationi

Entry nameiCADA_LISMN
AccessioniPrimary (citable) accession number: Q60048
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid, Transposable element

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