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Q60042

- XYNA_THENE

UniProt

Q60042 - XYNA_THENE

Protein

Endo-1,4-beta-xylanase A

Gene

xynA

Organism
Thermotoga neapolitana
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

    pH dependencei

    Optimum pH is 5.5-6.

    Temperature dependencei

    Optimum temperature is 102 degrees Celsius. Thermostable.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei498 – 4981Proton donorBy similarity
    Active sitei604 – 6041NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. endo-1,4-beta-xylanase activity Source: UniProtKB-EC

    GO - Biological processi

    1. xylan catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

    Protein family/group databases

    CAZyiCBM22. Carbohydrate-Binding Module Family 22.
    CBM9. Carbohydrate-Binding Module Family 9.
    GH10. Glycoside Hydrolase Family 10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endo-1,4-beta-xylanase A (EC:3.2.1.8)
    Short name:
    Xylanase A
    Alternative name(s):
    1,4-beta-D-xylan xylanohydrolase A
    Endoxylanase
    Gene namesi
    Name:xynA
    OrganismiThermotoga neapolitana
    Taxonomic identifieri2337 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 10551026Endo-1,4-beta-xylanase APRO_0000007987Add
    BLAST

    Proteomic databases

    PRIDEiQ60042.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60042.
    SMRiQ60042. Positions 867-1055.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini720 – 851132CBM-cenC 1Add
    BLAST
    Domaini895 – 1040146CBM-cenC 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 367338AAdd
    BLAST
    Regioni371 – 687317B, catalyticAdd
    BLAST

    Domaini

    The C-terminal CBM-CenC domains mediate the binding of XynA to microcrystalline cellulose. CBM-CenC 2 alone can also promote cellulose binding By similarity.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    2.60.40.1190. 2 hits.
    3.20.20.80. 1 hit.
    InterProiIPR010502. Carb-bd_dom_fam9.
    IPR003305. CenC_carb-bd.
    IPR008979. Galactose-bd-like.
    IPR001000. Glyco_hydro_10.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR006311. TAT_signal.
    [Graphical view]
    PfamiPF02018. CBM_4_9. 2 hits.
    PF06452. DUF1083. 2 hits.
    PF00331. Glyco_hydro_10. 1 hit.
    [Graphical view]
    PRINTSiPR00134. GLHYDRLASE10.
    SMARTiSM00633. Glyco_10. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60042-1 [UniParc]FASTAAdd to Basket

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    MRKKRRGFLN ASTAVLVGIL AGFLGVVLAA TGALGFAVRE SLLLKQFLFL     50
    SFEGNTDGAS PFGKDVVVTA SQDVAADGEY SLKVENRTSV WDGVEIDLTG 100
    KVNTGTDYLL SFHVYQTSDS PQLFSVLART EDEKGERYKI LADKVVVPNY 150
    WKEILVPFSP TFEGTPAKFS LIITSPKKTD FVFYVDNVQV LTPKEAGPKV 200
    VYETSFEKGI GDWQPRGSDV KISISPKVAH SGKKSLFVSN RQKGWHGAQI 250
    SLKGILKTGK TYAFEAWVYQ ESGQDQTIIM TMQRKYSSDS STKYEWIKAA 300
    TVPSGQWVQL SGTYTIPAGV TVEDLTLYFE SQNPTLEFYV DDVKVVDTTS 350
    AEIKLEMNPE EEIPALKDVL KDYFRVGVAL PSKVFINQKD IALISKHSNS 400
    STAENEMKPD SLLAGIENGK LKFRFETADK YIEFAQQNGM VVRGHTLVWH 450
    NQTPEWFFKD ENGNLLSKEE MTERLREYIH TVVGHFKGKV YAWDVVNEAV 500
    DPNQPDGLRR STWYQIMGPD YIELAFKFAR EADPNAKLFY NDYNTFEPKK 550
    RDIIYNLVKS LKEKGLIDGI GMQCHISLAT DIRQIEEAIK KFSTIPGIEI 600
    HITELDISVY RDSTSNYSEA PRTALIEQAH KMAQLFKIFK KYSNVITNVT 650
    FWGLKDDYSW RATRRNDWPL IFDKDYQAKL AYWAIVAPEV LPPLPKESKI 700
    SEGEAVVVGM MDDSYMMSKP IEIYDEEGNV KATIRAIWKD STIYVYGEVQ 750
    DATKKPAEDG VAIFINPNNE RTPYLQPDDT YVVLWTNWKS EVNREDVEVK 800
    KFVGPGFRRY SFEMSITIPG VEFKKDSYIG FDVAVIDDGK WYSWSDTTNS 850
    QKTNTMNYGT LKLEGVMVAT AKYGTPVIDG EIDDIWNTTE EIETKSVAMG 900
    SLEKNATAKV RVLWDEENLY VLAIVKDPVL NKDNSNPWEQ DSVEIFIDEN 950
    NHKTGYYEDD DAQFRVNYMN EQSFGTGASA ARFKTAVKLI EGGYIVEAAI 1000
    KWKTIKPSPN TVIGFNVQVN DANEKGQRVG IISWSDPTNN SWRDPSKFGN 1050
    LRLIK 1055
    Length:1,055
    Mass (Da):119,323
    Last modified:November 1, 1997 - v1
    Checksum:iF939845878B87468
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46945 Genomic DNA. Translation: CAA87069.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46945 Genomic DNA. Translation: CAA87069.1 .

    3D structure databases

    ProteinModelPortali Q60042.
    SMRi Q60042. Positions 867-1055.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM22. Carbohydrate-Binding Module Family 22.
    CBM9. Carbohydrate-Binding Module Family 9.
    GH10. Glycoside Hydrolase Family 10.

    Proteomic databases

    PRIDEi Q60042.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    2.60.40.1190. 2 hits.
    3.20.20.80. 1 hit.
    InterProi IPR010502. Carb-bd_dom_fam9.
    IPR003305. CenC_carb-bd.
    IPR008979. Galactose-bd-like.
    IPR001000. Glyco_hydro_10.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR006311. TAT_signal.
    [Graphical view ]
    Pfami PF02018. CBM_4_9. 2 hits.
    PF06452. DUF1083. 2 hits.
    PF00331. Glyco_hydro_10. 1 hit.
    [Graphical view ]
    PRINTSi PR00134. GLHYDRLASE10.
    SMARTi SM00633. Glyco_10. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS00591. GLYCOSYL_HYDROL_F10. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The multidomain xylanase A of the hyperthermophilic bacterium Thermotoga neapolitana is extremely thermoresistant."
      Zverlov V., Piotukh K., Dakhova O., Velikodvorskaya G., Borriss R.
      Appl. Microbiol. Biotechnol. 45:245-247(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Z2706-MC24.

    Entry informationi

    Entry nameiXYNA_THENE
    AccessioniPrimary (citable) accession number: Q60042
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3