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Q60042

- XYNA_THENE

UniProt

Q60042 - XYNA_THENE

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Protein
Endo-1,4-beta-xylanase A
Gene
xynA
Organism
Thermotoga neapolitana
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

pH dependencei

Optimum pH is 5.5-6.

Temperature dependencei

Optimum temperature is 102 degrees Celsius. Thermostable.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei498 – 4981Proton donor By similarity
Active sitei604 – 6041Nucleophile By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. endo-1,4-beta-xylanase activity Source: UniProtKB-EC

GO - Biological processi

  1. xylan catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Protein family/group databases

CAZyiCBM22. Carbohydrate-Binding Module Family 22.
CBM9. Carbohydrate-Binding Module Family 9.
GH10. Glycoside Hydrolase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase A (EC:3.2.1.8)
Short name:
Xylanase A
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase A
Endoxylanase
Gene namesi
Name:xynA
OrganismiThermotoga neapolitana
Taxonomic identifieri2337 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 10551026Endo-1,4-beta-xylanase A
PRO_0000007987Add
BLAST

Proteomic databases

PRIDEiQ60042.

Structurei

3D structure databases

ProteinModelPortaliQ60042.
SMRiQ60042. Positions 867-1055.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini720 – 851132CBM-cenC 1
Add
BLAST
Domaini895 – 1040146CBM-cenC 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 367338A
Add
BLAST
Regioni371 – 687317B, catalytic
Add
BLAST

Domaini

The C-terminal CBM-CenC domains mediate the binding of XynA to microcrystalline cellulose. CBM-CenC 2 alone can also promote cellulose binding By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.40.1190. 2 hits.
3.20.20.80. 1 hit.
InterProiIPR010502. Carb-bd_dom_fam9.
IPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001000. Glyco_hydro_10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF02018. CBM_4_9. 2 hits.
PF06452. DUF1083. 2 hits.
PF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60042-1 [UniParc]FASTAAdd to Basket

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MRKKRRGFLN ASTAVLVGIL AGFLGVVLAA TGALGFAVRE SLLLKQFLFL     50
SFEGNTDGAS PFGKDVVVTA SQDVAADGEY SLKVENRTSV WDGVEIDLTG 100
KVNTGTDYLL SFHVYQTSDS PQLFSVLART EDEKGERYKI LADKVVVPNY 150
WKEILVPFSP TFEGTPAKFS LIITSPKKTD FVFYVDNVQV LTPKEAGPKV 200
VYETSFEKGI GDWQPRGSDV KISISPKVAH SGKKSLFVSN RQKGWHGAQI 250
SLKGILKTGK TYAFEAWVYQ ESGQDQTIIM TMQRKYSSDS STKYEWIKAA 300
TVPSGQWVQL SGTYTIPAGV TVEDLTLYFE SQNPTLEFYV DDVKVVDTTS 350
AEIKLEMNPE EEIPALKDVL KDYFRVGVAL PSKVFINQKD IALISKHSNS 400
STAENEMKPD SLLAGIENGK LKFRFETADK YIEFAQQNGM VVRGHTLVWH 450
NQTPEWFFKD ENGNLLSKEE MTERLREYIH TVVGHFKGKV YAWDVVNEAV 500
DPNQPDGLRR STWYQIMGPD YIELAFKFAR EADPNAKLFY NDYNTFEPKK 550
RDIIYNLVKS LKEKGLIDGI GMQCHISLAT DIRQIEEAIK KFSTIPGIEI 600
HITELDISVY RDSTSNYSEA PRTALIEQAH KMAQLFKIFK KYSNVITNVT 650
FWGLKDDYSW RATRRNDWPL IFDKDYQAKL AYWAIVAPEV LPPLPKESKI 700
SEGEAVVVGM MDDSYMMSKP IEIYDEEGNV KATIRAIWKD STIYVYGEVQ 750
DATKKPAEDG VAIFINPNNE RTPYLQPDDT YVVLWTNWKS EVNREDVEVK 800
KFVGPGFRRY SFEMSITIPG VEFKKDSYIG FDVAVIDDGK WYSWSDTTNS 850
QKTNTMNYGT LKLEGVMVAT AKYGTPVIDG EIDDIWNTTE EIETKSVAMG 900
SLEKNATAKV RVLWDEENLY VLAIVKDPVL NKDNSNPWEQ DSVEIFIDEN 950
NHKTGYYEDD DAQFRVNYMN EQSFGTGASA ARFKTAVKLI EGGYIVEAAI 1000
KWKTIKPSPN TVIGFNVQVN DANEKGQRVG IISWSDPTNN SWRDPSKFGN 1050
LRLIK 1055
Length:1,055
Mass (Da):119,323
Last modified:November 1, 1997 - v1
Checksum:iF939845878B87468
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46945 Genomic DNA. Translation: CAA87069.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46945 Genomic DNA. Translation: CAA87069.1 .

3D structure databases

ProteinModelPortali Q60042.
SMRi Q60042. Positions 867-1055.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi CBM22. Carbohydrate-Binding Module Family 22.
CBM9. Carbohydrate-Binding Module Family 9.
GH10. Glycoside Hydrolase Family 10.

Proteomic databases

PRIDEi Q60042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.260. 2 hits.
2.60.40.1190. 2 hits.
3.20.20.80. 1 hit.
InterProi IPR010502. Carb-bd_dom_fam9.
IPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001000. Glyco_hydro_10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF02018. CBM_4_9. 2 hits.
PF06452. DUF1083. 2 hits.
PF00331. Glyco_hydro_10. 1 hit.
[Graphical view ]
PRINTSi PR00134. GLHYDRLASE10.
SMARTi SM00633. Glyco_10. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS00591. GLYCOSYL_HYDROL_F10. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The multidomain xylanase A of the hyperthermophilic bacterium Thermotoga neapolitana is extremely thermoresistant."
    Zverlov V., Piotukh K., Dakhova O., Velikodvorskaya G., Borriss R.
    Appl. Microbiol. Biotechnol. 45:245-247(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Z2706-MC24.

Entry informationi

Entry nameiXYNA_THENE
AccessioniPrimary (citable) accession number: Q60042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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