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Protein

Glucanase

Gene

E3

Organism
Thermobifida fusca (Thermomonospora fusca)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi180CalciumCombined sources1
Active sitei264UniRule annotation1
Active sitei312Proton donorUniRule annotation1
Metal bindingi457Calcium; via carbonyl oxygenCombined sources1
Active sitei535NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationImported, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradationUniRule annotation, Polysaccharide degradation
LigandCalciumCombined sources, Metal-bindingCombined sources

Protein family/group databases

CAZyiCBM2 Carbohydrate-Binding Module Family 2
GH6 Glycoside Hydrolase Family 6

Names & Taxonomyi

Protein namesi
Recommended name:
GlucanaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:E3Imported
OrganismiThermobifida fusca (Thermomonospora fusca)Imported
Taxonomic identifieri2021 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33UniRule annotationAdd BLAST33
ChainiPRO_500514382934 – 596GlucanaseUniRule annotationAdd BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi265 ↔ 330Combined sources
Disulfide bondi503 ↔ 553Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B4FX-ray2.20A/B177-596[»]
4B4HX-ray1.50A/B177-596[»]
ProteinModelPortaliQ60029
SMRiQ60029
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 142CBM2InterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the glycosyl hydrolase family 6.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG41065HY Bacteria
COG5297 LUCA

Family and domain databases

Gene3Di2.60.40.290, 1 hit
3.20.20.40, 1 hit
InterProiView protein in InterPro
IPR016288 Beta_cellobiohydrolase
IPR036434 Beta_cellobiohydrolase_sf
IPR001919 CBD2
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR012291 CBM2_carb-bd_dom_sf
IPR001524 Glyco_hydro_6_CS
IPR006311 TAT_signal
PANTHERiPTHR34876 PTHR34876, 1 hit
PfamiView protein in Pfam
PF00553 CBM_2, 1 hit
PF01341 Glyco_hydro_6, 1 hit
PIRSFiPIRSF001100 Beta_cellobiohydrolase, 1 hit
PRINTSiPR00733 GLHYDRLASE6
SMARTiView protein in SMART
SM00637 CBD_II, 1 hit
SUPFAMiSSF49384 SSF49384, 1 hit
SSF51989 SSF51989, 1 hit
PROSITEiView protein in PROSITE
PS51173 CBM2, 1 hit
PS00655 GLYCOSYL_HYDROL_F6_1, 1 hit
PS51318 TAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVRATNRR SWMRRGLAAA SGLALGASMV AFAAPANAAG CSVDYTVNSW
60 70 80 90 100
GTGFTANVTI TNLGSAINGW TLEWDFPGNQ QVTNLWNGTY TQSGQHVSVS
110 120 130 140 150
NAPYNASIPA NGTVEFGFNG SYSGSNDIPS SFKLNGVTCD GSDDPDPEPS
160 170 180 190 200
PSPSPSPSPT DPDEPGGPTN PPTNPGEKVD NPFEGAKLYV NPVWSAKAAA
210 220 230 240 250
EPGGSAVANE STAVWLDRIG AIEGNDSPTT GSMGLRDHLE EAVRQSGGDP
260 270 280 290 300
LTIQVVIYNL PGRDCAALAS NGELGPDELD RYKSEYIDPI ADIMWDFADY
310 320 330 340 350
ENLRIVAIIE IDSLPNLVTN VGGNGGTELC AYMKQNGGYV NGVGYALRKL
360 370 380 390 400
GEIPNVYNYI DAAHHGWIGW DSNFGPSVDI FYEAANASGS TVDYVHGFIS
410 420 430 440 450
NTANYSATVE PYLDVNGTVN GQLIRQSKWV DWNQYVDELS FVQDLRQALI
460 470 480 490 500
AKGFRSDIGM LIDTSRNGWG GPNRPTGPSS STDLNTYVDE SRIDRRIHPG
510 520 530 540 550
NWCNQAGAGL GERPTVNPAP GVDAYVWVKP PGESDGASEE IPNDEGKGFD
560 570 580 590
RMCDPTYQGN ARNGNNPSGA LPNAPISGHW FSAQFRELLA NAYPPL
Length:596
Mass (Da):63,548
Last modified:November 1, 1996 - v1
Checksum:iB0FA5277FE7721E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18978 Genomic DNA Translation: AAA62211.1
PIRiA55976

Similar proteinsi

Entry informationi

Entry nameiQ60029_THEFU
AccessioniPrimary (citable) accession number: Q60029
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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