Q60013 (AAT_STRVG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate aminotransferase
Short name=AspAT
EC=2.6.1.1

Alternative name(s):
Transaminase A

Gene names

Name:	aspC
Synonyms:	aat

Organism

Streptomyces virginiae

Taxonomic identifier

1961 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Gene Ontology (GO)
Biological_process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Aspartate aminotransferase		PRO_0000123853
Sites
	Binding site	36	1	Aspartate; via amide nitrogen By similarity
	Binding site	123	1	Aspartate By similarity
	Binding site	173	1	Aspartate By similarity
	Binding site	371	1	Aspartate By similarity
Amino acid modifications
	Modified residue	236	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q60013 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EEFEDCEB7D923065	FASTA	397	42,381
	10 20 30 40 50 60 MSARIGAISE SATLAVDAKA KALKAAGRPV IGFGAGEPDF PTPDYIVEAA VEACRNPKYH 70 80 90 100 110 120 RYTPAGGLPE LKAAIAAKTL RDSGYEVEAS QVLVTNGGKQ AIYEAFAAIL DPGDEVIVPA 130 140 150 160 170 180 PYWTTYPESI RLAGGVPVDV VADETTGYRV SVEQLEAART ERTKVVLFVS PSNPTGSVYS 190 200 210 220 230 240 EADAKAIGEW AAEHGLWVLT DEIYEHLVYG EAKFTSLPVL VPALRDKCII VNGVAKTYAM 250 260 270 280 290 300 TGWRVGWVIA PQDVIKAATN LQSHATSNVS NVAQVAALAA VSGNLDAVAE MRKAFDRRRQ 310 320 330 340 350 360 TMVKMLNEID GVFCPTPEGA FYAYPSVKEL LGKEIRGKRP QSSVELAALI LDEVEVAVVP 370 380 390 GEAFGTPGYL RLSYALGDED LVEGVSRIQK LLAEAKA

References

[1]	"Gene organization in the ada-rplL region of Streptomyces virginiae." Katayama M., Sakai Y., Okamoto S., Ihara F., Nihira T., Yamada Y. Gene 171:135-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50624 Genomic DNA. Translation: BAA09299.1.
PIR	T11786.
3D structure databases
ProteinModelPortal	Q60013.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR004839. Aminotransferase_I/II. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAT_STRVG

Accession

Primary (citable) accession number: Q60013

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program