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Protein

Aspartate aminotransferase

Gene

aspC

Organism
Streptomyces virginiae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Aspartate; via amide nitrogenBy similarity
Binding sitei123 – 1231AspartateBy similarity
Binding sitei173 – 1731AspartateBy similarity
Binding sitei371 – 3711AspartateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspC
Synonyms:aat
OrganismiStreptomyces virginiae
Taxonomic identifieri1961 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Aspartate aminotransferasePRO_0000123853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ60013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARIGAISE SATLAVDAKA KALKAAGRPV IGFGAGEPDF PTPDYIVEAA
60 70 80 90 100
VEACRNPKYH RYTPAGGLPE LKAAIAAKTL RDSGYEVEAS QVLVTNGGKQ
110 120 130 140 150
AIYEAFAAIL DPGDEVIVPA PYWTTYPESI RLAGGVPVDV VADETTGYRV
160 170 180 190 200
SVEQLEAART ERTKVVLFVS PSNPTGSVYS EADAKAIGEW AAEHGLWVLT
210 220 230 240 250
DEIYEHLVYG EAKFTSLPVL VPALRDKCII VNGVAKTYAM TGWRVGWVIA
260 270 280 290 300
PQDVIKAATN LQSHATSNVS NVAQVAALAA VSGNLDAVAE MRKAFDRRRQ
310 320 330 340 350
TMVKMLNEID GVFCPTPEGA FYAYPSVKEL LGKEIRGKRP QSSVELAALI
360 370 380 390
LDEVEVAVVP GEAFGTPGYL RLSYALGDED LVEGVSRIQK LLAEAKA
Length:397
Mass (Da):42,381
Last modified:November 1, 1996 - v1
Checksum:iEEFEDCEB7D923065
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50624 Genomic DNA. Translation: BAA09299.1.
PIRiT11786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50624 Genomic DNA. Translation: BAA09299.1.
PIRiT11786.

3D structure databases

ProteinModelPortaliQ60013.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Gene organization in the ada-rplL region of Streptomyces virginiae."
    Katayama M., Sakai Y., Okamoto S., Ihara F., Nihira T., Yamada Y.
    Gene 171:135-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiAAT_STRVG
AccessioniPrimary (citable) accession number: Q60013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.