Q5ZZT0 (KITH_MYCH2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	tdk
Ordered Locus Names:	mhp627

Organism

Mycoplasma hyopneumoniae (strain 232) [Complete proteome] [HAMAP]

Taxonomic identifier

295358 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma hyopneumoniae

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 184	184	Thymidine kinase HAMAP-Rule MF_00124		PRO_0000174995
Regions
	Nucleotide binding	15 – 22	8	ATP By similarity
	Nucleotide binding	89 – 92	4	ATP By similarity
Sites
	Active site	90	1	Proton acceptor Potential
	Metal binding	146	1	Zinc By similarity
	Metal binding	149	1	Zinc By similarity
	Metal binding	178	1	Zinc By similarity
	Metal binding	181	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZZT0 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: D9F531A695AC2BED	FASTA	184	20,911
	10 20 30 40 50 60 MYKKFFDGVI EVITGPMFSG KSDELIKRIK ILTYADIKTL VIKPSVDYRF SQCEIVSRSG 70 80 90 100 110 120 LKIPTFLART TQEIRDLFTR DNYQAIAIDE IQFFDEEIVT FLEQIADKGI RVIVSGLDQD 130 140 150 160 170 180 FRRKPFGSLP NLMAIAENVT KLQAVCSLCK RAATTTARKV LNEAQTLIGD QDEYEARCRA CHSL

References

[1]

"The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis." Minion F.C., Lefkowitz E.J., Madsen M.L., Cleary B.J., Swartzell S.M., Mahairas G.G. J. Bacteriol. 186:7123-7133(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 232.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017332 Genomic DNA. Translation: AAV27647.1.
RefSeq	YP_116135.1. NC_006360.1.
3D structure databases
ProteinModelPortal	Q5ZZT0.
ModBase	Search...
Protein-protein interaction databases
STRING	295358.mhp627.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAV27647; AAV27647; mhp627.
GeneID	3105612.
KEGG	mhy:mhp627.
PATRIC	20011935. VBIMycHyo77580_0670.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
HOGENOM	HOG000076390.
KO	K00857.
OMA	KVHAICV.
ProtClustDB	PRK04296.
Enzyme and pathway databases
BioCyc	MHYO295358:GH8B-621-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_MYCH2

Accession

Primary (citable) accession number: Q5ZZT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program