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Q5ZZT0 (KITH_MYCH2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:mhp627
OrganismMycoplasma hyopneumoniae (strain 232) [Complete proteome] [HAMAP]
Taxonomic identifier295358 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 184184Thymidine kinase HAMAP-Rule MF_00124
PRO_0000174995

Regions

Nucleotide binding15 – 228ATP By similarity
Nucleotide binding89 – 924ATP By similarity

Sites

Active site901Proton acceptor Potential
Metal binding1461Zinc By similarity
Metal binding1491Zinc By similarity
Metal binding1781Zinc By similarity
Metal binding1811Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZZT0 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: D9F531A695AC2BED

FASTA18420,911
        10         20         30         40         50         60 
MYKKFFDGVI EVITGPMFSG KSDELIKRIK ILTYADIKTL VIKPSVDYRF SQCEIVSRSG 

        70         80         90        100        110        120 
LKIPTFLART TQEIRDLFTR DNYQAIAIDE IQFFDEEIVT FLEQIADKGI RVIVSGLDQD 

       130        140        150        160        170        180 
FRRKPFGSLP NLMAIAENVT KLQAVCSLCK RAATTTARKV LNEAQTLIGD QDEYEARCRA 


CHSL 

« Hide

References

[1]"The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis."
Minion F.C., Lefkowitz E.J., Madsen M.L., Cleary B.J., Swartzell S.M., Mahairas G.G.
J. Bacteriol. 186:7123-7133(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 232.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017332 Genomic DNA. Translation: AAV27647.1.
RefSeqYP_116135.1. NC_006360.1.

3D structure databases

ProteinModelPortalQ5ZZT0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING295358.mhp627.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV27647; AAV27647; mhp627.
GeneID3105612.
KEGGmhy:mhp627.
PATRIC20011935. VBIMycHyo77580_0670.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076390.
KOK00857.
OMAKVHAICV.
OrthoDBEOG69D3J2.
ProtClustDBPRK04296.

Enzyme and pathway databases

BioCycMHYO295358:GH8B-651-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_MYCH2
AccessionPrimary (citable) accession number: Q5ZZT0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families