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Q5ZZB6

- Q5ZZB6_LEGPH

UniProt

Q5ZZB6 - Q5ZZB6_LEGPH

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Protein
Submitted name:

Cytosolic IMP-GMP specific 5'-nucleotidase

Gene

lpg0095

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Cofactori

Note: Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei23 – 231NucleophileUniRule annotation
Metal bindingi23 – 231MagnesiumUniRule annotationImported
Active sitei25 – 251Proton donorUniRule annotation
Metal bindingi25 – 251Magnesium; via carbonyl oxygenUniRule annotationImported
Metal bindingi303 – 3031MagnesiumUniRule annotationImported

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotationImported, Metal-bindingUniRule annotationImported

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-95-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Cytosolic IMP-GMP specific 5'-nucleotidaseImported
Gene namesi
Ordered Locus Names:lpg0095Imported
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)Imported
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000609: Chromosome

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-9087522,EBI-9087522

Protein-protein interaction databases

STRINGi272624.lpg0095.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BDEX-ray2.90A1-459[»]
4G63X-ray2.70A1-459[»]
4OHFX-ray2.53A/B/C/D1-459[»]
ProteinModelPortaliQ5ZZB6.
SMRiQ5ZZB6. Positions 2-459.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5ZZB6.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG75103.
HOGENOMiHOG000277902.
OMAiYLFSISE.
OrthoDBiEOG6FJN98.

Family and domain databases

Gene3Di3.40.50.1000. 3 hits.
InterProiIPR023214. HAD-like_dom.
IPR008380. HAD-SF_hydro_IG_5-nucl.
IPR016695. Pur_nucleotidase.
[Graphical view]
PANTHERiPTHR12103. PTHR12103. 1 hit.
PfamiPF05761. 5_nucleotid. 1 hit.
[Graphical view]
PIRSFiPIRSF017434. Purine_5'-nucleotidase. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02244. HAD-IG-Ncltidse. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZZB6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTHKVFVNR IINMRKIKLI GLDMDHTLIR YNSKNFESLV YDLVKERLAE
60 70 80 90 100
SFHYPEEIKK FKFNFDDAIR GLVIDSKNGN ILKLSRYGAI RLSYHGTKQI
110 120 130 140 150
SFSDQKKIYR SIYVDLGDPN YMAIDTSFSI AFCILYGQLV DLKDTNPDKM
160 170 180 190 200
PSYQAIAQDV QYCVDKVHSD GTLKNIIIKN LKKYVIREKE VVEGLKHFIR
210 220 230 240 250
YGKKIFILTN SEYSYSKLLL DYALSPFLDK GEHWQGLFEF VITLANKPRF
260 270 280 290 300
FYDNLRFLSV NPENGTMTNV HGPIVPGVYQ GGNAKKFTED LGVGGDEILY
310 320 330 340 350
IGDHIYGDIL RLKKDCNWRT ALVVEELGEE IASQIRALPI EKKIGEAMAI
360 370 380 390 400
KKELEQKYVD LCTRSIDESS QQYDQEIHDL QLQISTVDLQ ISRLLQEQNS
410 420 430 440 450
FYNPKWERVF RAGAEESYFA YQVDRFACIY MEKLSDLLEH SPMTYFRANR

RLLAHDIDI
Length:459
Mass (Da):53,379
Last modified:November 23, 2004 - v1
Checksum:i968D7681DAEA4EE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU26202.1.
RefSeqiYP_094149.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU26202; AAU26202; lpg0095.
GeneIDi19831662.
KEGGilpn:lpg0095.
lpu:LPE509_03144.
PATRICi22327110. VBILegPne29832_0101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU26202.1 .
RefSeqi YP_094149.1. NC_002942.5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BDE X-ray 2.90 A 1-459 [» ]
4G63 X-ray 2.70 A 1-459 [» ]
4OHF X-ray 2.53 A/B/C/D 1-459 [» ]
ProteinModelPortali Q5ZZB6.
SMRi Q5ZZB6. Positions 2-459.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272624.lpg0095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU26202 ; AAU26202 ; lpg0095 .
GeneIDi 19831662.
KEGGi lpn:lpg0095.
lpu:LPE509_03144.
PATRICi 22327110. VBILegPne29832_0101.

Phylogenomic databases

eggNOGi NOG75103.
HOGENOMi HOG000277902.
OMAi YLFSISE.
OrthoDBi EOG6FJN98.

Enzyme and pathway databases

BioCyci LPNE272624:GHDI-95-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5ZZB6.

Family and domain databases

Gene3Di 3.40.50.1000. 3 hits.
InterProi IPR023214. HAD-like_dom.
IPR008380. HAD-SF_hydro_IG_5-nucl.
IPR016695. Pur_nucleotidase.
[Graphical view ]
PANTHERi PTHR12103. PTHR12103. 1 hit.
Pfami PF05761. 5_nucleotid. 1 hit.
[Graphical view ]
PIRSFi PIRSF017434. Purine_5'-nucleotidase. 1 hit.
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02244. HAD-IG-Ncltidse. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Philadelphia 1 / ATCC 33152 / DSM 7513Imported.
  2. "Crystal Structure of the cytosolic IMP-GMP specific 5'-nucleotidase (lpg0095) from Legionella pneumophila, Northeast Structural Genomics Target LgR1."
    Forouhar F., Abashidze M., Ho C.K., Conover K., Acton T.B., Montelione G.T., Hunt J.F., Tong L.
    Submitted (OCT-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS).
  3. "Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila."
    Srinivasan B., Forouhar F., Shukla A., Sampangi C., Kulkarni S., Abashidze M., Seetharaman J., Lew S., Mao L., Acton T.B., Xiao R., Everett J.K., Montelione G.T., Tong L., Balaram H.
    FEBS J. 281:1613-1628(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.53 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

Entry informationi

Entry nameiQ5ZZB6_LEGPH
AccessioniPrimary (citable) accession number: Q5ZZB6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3