Cytosolic IMP-GMP specific 5'-nucleotidase - Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Cytosolic IMP-GMP specific 5'-nucleotidase EMBL AAU26202.1

Gene names

Ordered Locus Names:

lpg0095

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP] EMBL AAU26202.1

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella ›

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor

Binds 1 magnesium ion per subunit By similarity. PIRSR PIRSR017434-2

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR017434-2 Metal-binding PIRSR PIRSR017434-2
Technical term	3D-structure PDB 2BDE PDB 4G63 Complete proteome
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Active site

23

1

Nucleophile By similarity PIRSR PIRSR017434-1

Active site

25

1

Proton donor By similarity PIRSR PIRSR017434-1

Metal binding

23

1

Magnesium By similarity PIRSR PIRSR017434-2

Metal binding

25

1

Magnesium; via carbonyl oxygen By similarity PIRSR PIRSR017434-2

Metal binding

303

1

Magnesium By similarity PIRSR PIRSR017434-2

Sequences

Sequence

Length

Mass (Da)

Tools

Q5ZZB6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 968D7681DAEA4EE5
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FASTA

459

53,379

        10         20         30         40         50         60 
MDTHKVFVNR IINMRKIKLI GLDMDHTLIR YNSKNFESLV YDLVKERLAE SFHYPEEIKK 

        70         80         90        100        110        120 
FKFNFDDAIR GLVIDSKNGN ILKLSRYGAI RLSYHGTKQI SFSDQKKIYR SIYVDLGDPN 

       130        140        150        160        170        180 
YMAIDTSFSI AFCILYGQLV DLKDTNPDKM PSYQAIAQDV QYCVDKVHSD GTLKNIIIKN 

       190        200        210        220        230        240 
LKKYVIREKE VVEGLKHFIR YGKKIFILTN SEYSYSKLLL DYALSPFLDK GEHWQGLFEF 

       250        260        270        280        290        300 
VITLANKPRF FYDNLRFLSV NPENGTMTNV HGPIVPGVYQ GGNAKKFTED LGVGGDEILY 

       310        320        330        340        350        360 
IGDHIYGDIL RLKKDCNWRT ALVVEELGEE IASQIRALPI EKKIGEAMAI KKELEQKYVD 

       370        380        390        400        410        420 
LCTRSIDESS QQYDQEIHDL QLQISTVDLQ ISRLLQEQNS FYNPKWERVF RAGAEESYFA 

       430        440        450 
YQVDRFACIY MEKLSDLLEH SPMTYFRANR RLLAHDIDI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. Russo J.J. Science 305:1966-1968(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.
[2]	"Crystal Structure of the cytosolic IMP-GMP specific 5'-nucleotidase (lpg0095) from Legionella pneumophila, Northeast Structural Genomics Target LgR1." Forouhar F., Abashidze M., Ho C.K., Conover K., Acton T.B., Montelione G.T., Hunt J.F., Tong L. Submitted (OCT-2005) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS).
[3]	"Allosteric regulation and substrate activation in cytosolic nucleotidase ii from legionella pneumophila." Srinivasan B., Forouhar F., Shukla A., Sampangi C., Kulkarni S., Abashidze M., Seetharaman J., Lew S., Mao L., Acton T.B., Xiao R., Everett J.K., Montelione G.T., Tong L., Balaram H. Submitted (JUL-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE017354 Genomic DNA. Translation: AAU26202.1.

RefSeq

YP_094149.1. NC_002942.5.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2BDE	X-ray	2.90	A	1-459	[»]
4G63	X-ray	2.70	A	1-459	[»]

ProteinModelPortal

Q5ZZB6.

SMR

Q5ZZB6. Positions 2-459.

ModBase

Search...

Protein-protein interaction databases

STRING

272624.lpg0095.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAU26202; AAU26202; lpg0095.

GeneID

3078646.

KEGG

lpn:lpg0095.

PATRIC

22327110. VBILegPne29832_0101.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

NOG75103.

HOGENOM

HOG000277902.

OMA

HFIRYGK.

ProtClustDB

CLSK925689.

Enzyme and pathway databases

BioCyc

LPNE272624:GHDI-154-MONOMER.

Family and domain databases

Gene3D

3.40.50.1000. 3 hits.

InterPro

IPR023214. HAD-like_dom.
IPR008380. HAD-SF_hydro_IG_5-nucl.
IPR016695. Pur_nucleotidase.
[Graphical view]

PANTHER

PTHR12103. PTHR12103. 1 hit.

Pfam

PF05761. 5_nucleotid. 1 hit.
[Graphical view]

PIRSF

PIRSF017434. Purine_5'-nucleotidase. 1 hit.

SUPFAM

SSF56784. HAD-like_dom. 1 hit.

TIGRFAMs

TIGR02244. HAD-IG-Ncltidse. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q5ZZB6.

Entry information

Entry name

Q5ZZB6_LEGPH

Accession

Primary (citable) accession number: Q5ZZB6

Entry history

Integrated into UniProtKB/TrEMBL:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)