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Q5ZZB6

- Q5ZZB6_LEGPH

UniProt

Q5ZZB6 - Q5ZZB6_LEGPH

Protein
Submitted name:

Cytosolic IMP-GMP specific 5'-nucleotidase

Gene

lpg0095

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei23 – 231NucleophileUniRule annotation
    Metal bindingi23 – 231MagnesiumUniRule annotationImported
    Metal bindingi23 – 231Magnesium
    Active sitei25 – 251Proton donorUniRule annotation
    Metal bindingi25 – 251Magnesium; via carbonyl oxygenUniRule annotationImported
    Metal bindingi25 – 251Magnesium; via carbonyl oxygen
    Binding sitei187 – 1871Phosphate 3
    Metal bindingi303 – 3031MagnesiumUniRule annotationImported
    Metal bindingi303 – 3031Magnesium

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    MagnesiumUniRule annotationImported, Metal-bindingUniRule annotationImported

    Enzyme and pathway databases

    BioCyciLPNE272624:GHDI-95-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cytosolic IMP-GMP specific 5'-nucleotidaseImported
    Gene namesi
    Ordered Locus Names:lpg0095Imported
    OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)Imported
    Taxonomic identifieri272624 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000000609: Chromosome

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-9087522,EBI-9087522

    Protein-protein interaction databases

    STRINGi272624.lpg0095.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BDEX-ray2.90A1-459[»]
    4G63X-ray2.70A1-459[»]
    4OHFX-ray2.53A/B/C/D1-459[»]
    ProteinModelPortaliQ5ZZB6.
    SMRiQ5ZZB6. Positions 2-459.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5ZZB6.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG75103.
    HOGENOMiHOG000277902.
    OMAiYLFSISE.
    OrthoDBiEOG6FJN98.

    Family and domain databases

    Gene3Di3.40.50.1000. 3 hits.
    InterProiIPR023214. HAD-like_dom.
    IPR008380. HAD-SF_hydro_IG_5-nucl.
    IPR016695. Pur_nucleotidase.
    [Graphical view]
    PANTHERiPTHR12103. PTHR12103. 1 hit.
    PfamiPF05761. 5_nucleotid. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017434. Purine_5'-nucleotidase. 1 hit.
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02244. HAD-IG-Ncltidse. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5ZZB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTHKVFVNR IINMRKIKLI GLDMDHTLIR YNSKNFESLV YDLVKERLAE    50
    SFHYPEEIKK FKFNFDDAIR GLVIDSKNGN ILKLSRYGAI RLSYHGTKQI 100
    SFSDQKKIYR SIYVDLGDPN YMAIDTSFSI AFCILYGQLV DLKDTNPDKM 150
    PSYQAIAQDV QYCVDKVHSD GTLKNIIIKN LKKYVIREKE VVEGLKHFIR 200
    YGKKIFILTN SEYSYSKLLL DYALSPFLDK GEHWQGLFEF VITLANKPRF 250
    FYDNLRFLSV NPENGTMTNV HGPIVPGVYQ GGNAKKFTED LGVGGDEILY 300
    IGDHIYGDIL RLKKDCNWRT ALVVEELGEE IASQIRALPI EKKIGEAMAI 350
    KKELEQKYVD LCTRSIDESS QQYDQEIHDL QLQISTVDLQ ISRLLQEQNS 400
    FYNPKWERVF RAGAEESYFA YQVDRFACIY MEKLSDLLEH SPMTYFRANR 450
    RLLAHDIDI 459
    Length:459
    Mass (Da):53,379
    Last modified:November 23, 2004 - v1
    Checksum:i968D7681DAEA4EE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017354 Genomic DNA. Translation: AAU26202.1.
    RefSeqiYP_007569687.1. NC_020521.1.
    YP_094149.1. NC_002942.5.

    Genome annotation databases

    EnsemblBacteriaiAAU26202; AAU26202; lpg0095.
    GeneIDi14801836.
    3078646.
    KEGGilpn:lpg0095.
    lpu:LPE509_03144.
    PATRICi22327110. VBILegPne29832_0101.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017354 Genomic DNA. Translation: AAU26202.1 .
    RefSeqi YP_007569687.1. NC_020521.1.
    YP_094149.1. NC_002942.5.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BDE X-ray 2.90 A 1-459 [» ]
    4G63 X-ray 2.70 A 1-459 [» ]
    4OHF X-ray 2.53 A/B/C/D 1-459 [» ]
    ProteinModelPortali Q5ZZB6.
    SMRi Q5ZZB6. Positions 2-459.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272624.lpg0095.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU26202 ; AAU26202 ; lpg0095 .
    GeneIDi 14801836.
    3078646.
    KEGGi lpn:lpg0095.
    lpu:LPE509_03144.
    PATRICi 22327110. VBILegPne29832_0101.

    Phylogenomic databases

    eggNOGi NOG75103.
    HOGENOMi HOG000277902.
    OMAi YLFSISE.
    OrthoDBi EOG6FJN98.

    Enzyme and pathway databases

    BioCyci LPNE272624:GHDI-95-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5ZZB6.

    Family and domain databases

    Gene3Di 3.40.50.1000. 3 hits.
    InterProi IPR023214. HAD-like_dom.
    IPR008380. HAD-SF_hydro_IG_5-nucl.
    IPR016695. Pur_nucleotidase.
    [Graphical view ]
    PANTHERi PTHR12103. PTHR12103. 1 hit.
    Pfami PF05761. 5_nucleotid. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017434. Purine_5'-nucleotidase. 1 hit.
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02244. HAD-IG-Ncltidse. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Philadelphia 1 / ATCC 33152 / DSM 7513Imported.
    2. "Crystal Structure of the cytosolic IMP-GMP specific 5'-nucleotidase (lpg0095) from Legionella pneumophila, Northeast Structural Genomics Target LgR1."
      Forouhar F., Abashidze M., Ho C.K., Conover K., Acton T.B., Montelione G.T., Hunt J.F., Tong L.
      Submitted (OCT-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS).
    3. "Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila."
      Srinivasan B., Forouhar F., Shukla A., Sampangi C., Kulkarni S., Abashidze M., Seetharaman J., Lew S., Mao L., Acton T.B., Xiao R., Everett J.K., Montelione G.T., Tong L., Balaram H.
      FEBS J. 281:1613-1628(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.53 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

    Entry informationi

    Entry nameiQ5ZZB6_LEGPH
    AccessioniPrimary (citable) accession number: Q5ZZB6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 23, 2004
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3