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Q5ZZB6 (Q5ZZB6_LEGPH) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

Binds 1 magnesium ion per subunit By similarity. PIRSR PIRSR017434-2

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself2EBI-9087522,EBI-9087522

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region319 – 3202Phosphate 1 binding PDB 4G63
Region319 – 3202Sulfate 1 binding

Sites

Active site231Nucleophile By similarity PIRSR PIRSR017434-1
Active site251Proton donor By similarity PIRSR PIRSR017434-1
Metal binding231Magnesium By similarity
Metal binding251Magnesium; via carbonyl oxygen By similarity
Metal binding3031Magnesium By similarity
Binding site101Phosphate 1 PDB 4G63
Binding site101Sulfate 1
Binding site1821Sulfate 2
Binding site1871Phosphate 2 PDB 4G63
Binding site1871Sulfate 2
Binding site3131Phosphate 1 PDB 4G63
Binding site3131Sulfate 1
Binding site4281Phosphate 1; via amide nitrogen PDB 4G63
Binding site4281Sulfate 1; via amide nitrogen

Sequences

Sequence LengthMass (Da)Tools
Q5ZZB6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 968D7681DAEA4EE5

FASTA45953,379
        10         20         30         40         50         60 
MDTHKVFVNR IINMRKIKLI GLDMDHTLIR YNSKNFESLV YDLVKERLAE SFHYPEEIKK 

        70         80         90        100        110        120 
FKFNFDDAIR GLVIDSKNGN ILKLSRYGAI RLSYHGTKQI SFSDQKKIYR SIYVDLGDPN 

       130        140        150        160        170        180 
YMAIDTSFSI AFCILYGQLV DLKDTNPDKM PSYQAIAQDV QYCVDKVHSD GTLKNIIIKN 

       190        200        210        220        230        240 
LKKYVIREKE VVEGLKHFIR YGKKIFILTN SEYSYSKLLL DYALSPFLDK GEHWQGLFEF 

       250        260        270        280        290        300 
VITLANKPRF FYDNLRFLSV NPENGTMTNV HGPIVPGVYQ GGNAKKFTED LGVGGDEILY 

       310        320        330        340        350        360 
IGDHIYGDIL RLKKDCNWRT ALVVEELGEE IASQIRALPI EKKIGEAMAI KKELEQKYVD 

       370        380        390        400        410        420 
LCTRSIDESS QQYDQEIHDL QLQISTVDLQ ISRLLQEQNS FYNPKWERVF RAGAEESYFA 

       430        440        450 
YQVDRFACIY MEKLSDLLEH SPMTYFRANR RLLAHDIDI 

« Hide

References

« Hide 'large scale' references
[1]"The genomic sequence of the accidental pathogen Legionella pneumophila."
Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. expand/collapse author list , Georghiou A., Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J.
Science 305:1966-1968(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.
[2]"Crystal Structure of the cytosolic IMP-GMP specific 5'-nucleotidase (lpg0095) from Legionella pneumophila, Northeast Structural Genomics Target LgR1."
Forouhar F., Abashidze M., Ho C.K., Conover K., Acton T.B., Montelione G.T., Hunt J.F., Tong L.
Submitted (OCT-2005) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) IN COMPLEX WITH SULFATE.
[3]"Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila."
Srinivasan B., Forouhar F., Shukla A., Sampangi C., Kulkarni S., Abashidze M., Seetharaman J., Lew S., Mao L., Acton T.B., Xiao R., Everett J.K., Montelione G.T., Tong L., Balaram H.
FEBS J. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.53 ANGSTROMS) IN COMPLEX WITH PHOSPHATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017354 Genomic DNA. Translation: AAU26202.1.
RefSeqYP_007569687.1. NC_020521.1.
YP_094149.1. NC_002942.5.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BDEX-ray2.90A1-459[»]
4G63X-ray2.70A1-459[»]
4OHFX-ray2.53A/B/C/D1-459[»]
ProteinModelPortalQ5ZZB6.
SMRQ5ZZB6. Positions 2-459.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272624.lpg0095.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU26202; AAU26202; lpg0095.
GeneID14801836.
3078646.
KEGGlpn:lpg0095.
lpu:LPE509_03144.
PATRIC22327110. VBILegPne29832_0101.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG75103.
HOGENOMHOG000277902.
OMAWERVFRA.
OrthoDBEOG6FJN98.
ProtClustDBCLSK925689.

Enzyme and pathway databases

BioCycLPNE272624:GHDI-95-MONOMER.

Family and domain databases

Gene3D3.40.50.1000. 3 hits.
InterProIPR023214. HAD-like_dom.
IPR008380. HAD-SF_hydro_IG_5-nucl.
IPR016695. Pur_nucleotidase.
[Graphical view]
PANTHERPTHR12103. PTHR12103. 1 hit.
PfamPF05761. 5_nucleotid. 1 hit.
[Graphical view]
PIRSFPIRSF017434. Purine_5'-nucleotidase. 1 hit.
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02244. HAD-IG-Ncltidse. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ5ZZB6.

Entry information

Entry nameQ5ZZB6_LEGPH
AccessionPrimary (citable) accession number: Q5ZZB6
Entry history
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)