Q5ZYX0 (GLSA_LEGPH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutaminase
EC=3.5.1.2

Gene names

Name:	glsA
Ordered Locus Names:	lpg0241

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella › Legionella pneumophila › Legionella pneumophila subsp. pneumophila

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00313
Sequence similarities	Belongs to the glutaminase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glutamine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glutaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Glutaminase HAMAP-Rule MF_00313		PRO_1000079075
Sites
	Binding site	67	1	Substrate By similarity
	Binding site	118	1	Substrate By similarity
	Binding site	161	1	Substrate By similarity
	Binding site	168	1	Substrate By similarity
	Binding site	192	1	Substrate By similarity
	Binding site	244	1	Substrate By similarity
	Binding site	262	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZYX0 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: B5DE93FDB6BB5939	FASTA	310	33,970
	10 20 30 40 50 60 MSSKLLTIQL LEELVHAAEL NQEGKTADYI PELANVNQEL TAIAVQALGE KTLAYSNNPL 70 80 90 100 110 120 HPVTLQSTGK MIPLIGLLEE FGADQLFEWV KVEPSGDDFA SITRLEQFGP KPSNPMLNAG 130 140 150 160 170 180 AIALCSRIPG IGEQQFRWLE HWVQKLFNQR LSINPLVFAS EKRTGNRNRA LAYLLKSRNN 190 200 210 220 230 240 LGADVHETLD LYFALCSYEA MLDQMLYLPT LLANRGKDPD TGEQILSTET CKITLAIMAT 250 260 270 280 290 300 CGLYDETGTH MVKTGMPAKS GVSGYTIAVV PGKAGIVVLS PRVNAKGNSI RGEIMLEGLS 310 KAMNWHFALP

References

[1]

"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J. Science 305:1966-1968(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017354 Genomic DNA. Translation: AAU26348.1.
RefSeq	YP_007569527.1. NC_020521.1. YP_094295.1. NC_002942.5.
3D structure databases
ProteinModelPortal	Q5ZYX0.
ModBase	Search...
Protein-protein interaction databases
STRING	272624.lpg0241.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU26348; AAU26348; lpg0241.
GeneID	14801676. 3078211.
KEGG	lpn:lpg0241.
PATRIC	22327418. VBILegPne29832_0255.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2066.
HOGENOM	HOG000216890.
KO	K01425.
OMA	CKITLAI.
ProtClustDB	CLSK832083.
Enzyme and pathway databases
BioCyc	LPNE272624:GHDI-241-MONOMER.
Family and domain databases
Gene3D	3.40.710.10. 1 hit.
HAMAP	MF_00313. Glutaminase.
InterPro	IPR012338. Beta-lactam/transpept-like. IPR015868. Glutaminase. [Graphical view]
PANTHER	PTHR12544. PTHR12544. 1 hit.
Pfam	PF04960. Glutaminase. 1 hit. [Graphical view]
SUPFAM	SSF56601. PBP_transp_fold. 1 hit.
TIGRFAMs	TIGR03814. Gln_ase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLSA_LEGPH

Accession

Primary (citable) accession number: Q5ZYX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 23, 2004
Last modified:	May 29, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program