Reviewed, UniProtKB/Swiss-Prot Q5ZYR4 (LPTD_LEGPH)

Names and originHide

Protein names

Recommended name:
LPS-assembly protein lptD

Alternative name(s):
Organic solvent tolerance protein

Gene names

Name:	lptD
Synonyms:	imp, ostA
Ordered Locus Names:	lpg0297

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributesHide

Sequence length	839 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)Hide

Function	Involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis By similarity. HAMAP MF_01411
Subunit structure	Forms a high-molecular-weight complex in the outer membrane By similarity. HAMAP MF_01411
Subcellular location	Cell outer membrane By similarity HAMAP MF_01411.
Sequence similarities	Belongs to the lptD family.
Sequence caution	The sequence AAU26404.1 differs from that shown. Reason: Erroneous initiation.

OntologiesHide

Keywords
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Gram-negative-bacterium-type cell outer membrane assembly Inferred from electronic annotation. Source: HAMAP response to organic substance Inferred from electronic annotation. Source: InterPro
Cellular component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 839	818	LPS-assembly protein lptD HAMAP MF_01411		PRO_0000281615

SequencesHide

	Sequence		Length	Mass (Da)
	Q5ZYR4-1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: 28CC215A9FAF860D	FASTA	839	95,958
	10 20 30 40 50 60 MAIGITACVL SLINYQGLAY SAALINEPIQ ACVIAREVDL TDDIRTKFAQ CLGWQADQSS 70 80 90 100 110 120 PVCLGFYKPI AVTPLASPDE VRILADTASF YRTQRSTLSG HVEMQQGQRV VNAQTAYVYR 130 140 150 160 170 180 DPKTNEVTKI EFLNHVRYLE PDRMMIARKA VVYPQDKSGE VEDVLYRFNT NRSNALLPAW 190 200 210 220 230 240 GRASLIKRFA NQDYFLKEAT YTTCAPQDKA WAIEAESISI DNEKGKGIAR NAKLRIHEWP 250 260 270 280 290 300 VLYTPYLSFP TNRDRKSGFL MPIVGYSNVG GADLGIPYYW NMAPNYDMTL VPHLYTKRGL 310 320 330 340 350 360 MLGGQFRYLT SKSTGTFNGN FLPKDKAFGR FLQDNEVEFP QIRGLSTNRW EVNFVDSTQF 370 380 390 400 410 420 LSDLQLNVNF QQVSDDYYLQ DFSTNLASVT QRQLLRQADL TYTTENWTFR GMGQSYQTLH 430 440 450 460 470 480 PINEIPVSPV YERLPQLMAR GYYDDLPFNA QFNILGQYDQ FHWPNDSWNI ALNNMPQGPR 490 500 510 520 530 540 FHLNPILSVP MMKPWGYVTP SVQFVENYYD ISRNYTWGTS RANYNLTIPR YSLDGGLYFE 550 560 570 580 590 600 RDLHLKGTYY IQTLEPRLFY LRVPYYNQTL IPVYDSGFMI FNVDQLFRTN RFSGFDRIGD 610 620 630 640 650 660 ANQLSYALTT RWLEDESGAE KANFSIGQIK YFSERRVQLC QSPTGFCTDN PDTFGNLSST 670 680 690 700 710 720 FGTSPVASRA VYKFNPAWGI TGDYIWDPAT RATNNADLNL HYQPARNAII NGGYSYLVNG 730 740 750 760 770 780 DVTQVRNNDT ENNALHQAIL SAAWPLSEKW SGIGAYSYNI SKNYSMMSFL GVQYDSCCWA 790 800 810 820 830 MRILGGRIFR SLNEEFEPQY NNNIYLQILL KGLGSVASSD PSGILNTYIP GYYDPFRRR

ReferencesHide

[1]

"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J. Science 305:1966-1968(2004) [PubMed: 15448271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	AE017354 Genomic DNA. Translation: AAU26404.1. Different initiation.
RefSeq	YP_094351.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZYR4.
Genome annotation databases
GeneID	3080123.
GenomeReviews	Gene locus lpg0297 in contig AE017354_GR.
KEGG	lpn:lpg0297.
NMPDR	fig|272624.3.peg.1813.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1452.
HOGENOM	HBG520248.
OMA	TPYYWNI.
ProtClustDB	CLSK915165.
Enzyme and pathway databases
BioCyc	LPNE272624:LPG0297-MONOMER.
Family and domain databases
HAMAP	MF_01411. OstA. [Tree]
InterPro	IPR020889. LPS-assembly_LptD. IPR005653. OstA-like_N. IPR007543. OstA_C. [Graphical view]
Pfam	PF03968. OstA. 1 hit. PF04453. OstA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry informationHide

Entry name

LPTD_LEGPH

Accession

Primary (citable) accession number: Q5ZYR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	July 13, 2010
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)