Q5ZYA8 (AROQ_LEGPH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type II DHQase

Gene names

Name:	aroQ
Ordered Locus Names:	lpg0464

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella › Legionella pneumophila › Legionella pneumophila subsp. pneumophila

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a trans-dehydration via an enolate intermediate By similarity. HAMAP-Rule MF_00169
Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP-Rule MF_00169
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP-Rule MF_00169
Subunit structure	Homododecamer By similarity.
Sequence similarities	Belongs to the type-II 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	3-dehydroquinate dehydratase HAMAP-Rule MF_00169		PRO_1000077047
Regions
	Region	102 – 103	2	Substrate binding By similarity
Sites
	Active site	23	1	Proton acceptor By similarity
	Active site	101	1	Proton donor By similarity
	Binding site	75	1	Substrate By similarity
	Binding site	81	1	Substrate By similarity
	Binding site	88	1	Substrate By similarity
	Binding site	112	1	Substrate By similarity
	Site	18	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZYA8 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: D86C832939F54F26	FASTA	145	15,774
	10 20 30 40 50 60 MKKILVLHGP NLNLLGSREP SIYGHASLTQ INGDLIQEAD NAGIRLSCFQ SNAEAELIQA 70 80 90 100 110 120 VHQAGIDKIN YIIINPAAFT HTSIALRDAL SAVAIPFIEV HLSNIFSRET FRHHSYFSDI 130 140 AVGVISGLGT KGYLLALQAI IKELK

References

[1]

"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J. Science 305:1966-1968(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017354 Genomic DNA. Translation: AAU26561.1.
RefSeq	YP_094508.1. NC_002942.5.
3D structure databases
HSSP	HSSP built from PDB template 1UQR based on UniProtKB P43877.
ProteinModelPortal	Q5ZYA8.
SMR	Q5ZYA8. Positions 1-145.
ModBase	Search...
Protein-protein interaction databases
STRING	272624.lpg0464.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU26561; AAU26561; lpg0464.
GeneID	3079902.
KEGG	lpn:lpg0464.
PATRIC	22327886. VBILegPne29832_0480.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0757.
HOGENOM	HOG000217278.
KO	K03786.
OMA	RREPGHY.
ProtClustDB	PRK05395.
Enzyme and pathway databases
BioCyc	LPNE272624:GHDI-513-MONOMER.
UniPathway	UPA00053; UER00086.
Family and domain databases
Gene3D	3.40.50.9100. 1 hit.
HAMAP	MF_00169. AroQ.
InterPro	IPR001874. DHquinase_II. IPR018509. DHquinase_II_CS. [Graphical view]
PANTHER	PTHR21272. PTHR21272. 1 hit.
Pfam	PF01220. DHquinase_II. 1 hit. [Graphical view]
PIRSF	PIRSF001399. DHquinase_II. 1 hit.
ProDom	PD004527. DHquinase_II. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF52304. DHquinase_II. 1 hit.
TIGRFAMs	TIGR01088. aroQ. 1 hit.
PROSITE	PS01029. DEHYDROQUINASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROQ_LEGPH

Accession

Primary (citable) accession number: Q5ZYA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program