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Q5ZY91 (TRMB_LEGPH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA (guanine-N(7)-)-methyltransferase

EC=2.1.1.33
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene names
Name:trmB
Ordered Locus Names:lpg0481
OrganismLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]
Taxonomic identifier272624 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity. HAMAP-Rule MF_01057

Catalytic activity

S-adenosyl-L-methionine + guanine46 in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine46 in tRNA. HAMAP-Rule MF_01057

Pathway

tRNA modification; N(7)-methylguanine-tRNA biosynthesis. HAMAP-Rule MF_01057

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

Ontologies

Keywords
   Biological processtRNA processing
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226tRNA (guanine-N(7)-)-methyltransferase HAMAP-Rule MF_01057
PRO_0000229172

Regions

Region205 – 2084Substrate binding By similarity

Sites

Active site1321 By similarity
Binding site571S-adenosyl-L-methionine By similarity
Binding site821S-adenosyl-L-methionine By similarity
Binding site1091S-adenosyl-L-methionine By similarity
Binding site1321S-adenosyl-L-methionine By similarity
Binding site1361Substrate By similarity
Binding site1681Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZY91 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: C56FF0A1F8457ECE

FASTA22626,047
        10         20         30         40         50         60 
MMQRKIKSYV LRAGRISNRQ QQGLDLWLED YELKFDSPTP WNFAKEFGRH DADTIVEIGF 

        70         80         90        100        110        120 
GMGTSLFAMA MNNPQCNYLG IEVHKAGVGS LVADLHEYQI SNVRVVVHDA VEVLQTKIPE 

       130        140        150        160        170        180 
NSLAGVQIFF PDPWHKKRHH KRRLIQSEFI QMLVKKIRPS GFIHCATDWE DYAEHILNVL 

       190        200        210        220 
SSESALFNQQ KEGGYSPRPD SRPLTKFELR GERLGHGVWD LVFIKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017354 Genomic DNA. Translation: AAU26578.1.
RefSeqYP_094525.1. NC_002942.5.

3D structure databases

ProteinModelPortalQ5ZY91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272624.lpg0481.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU26578; AAU26578; lpg0481.
GeneID3079809.
KEGGlpn:lpg0481.
PATRIC22327928. VBILegPne29832_0501.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0220.
HOGENOMHOG000073968.
KOK03439.
OMAFIHCATD.
OrthoDBEOG6K6VBC.
ProtClustDBPRK00121.

Enzyme and pathway databases

BioCycLPNE272624:GHDI-481-MONOMER.
UniPathwayUPA00989.

Family and domain databases

HAMAPMF_01057. tRNA_methyltr_TrmB.
InterProIPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamPF02390. Methyltransf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00091. TIGR00091. 1 hit.
PROSITEPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRMB_LEGPH
AccessionPrimary (citable) accession number: Q5ZY91
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways