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Q5ZY78

- ASSY_LEGPH

UniProt

Q5ZY78 - ASSY_LEGPH

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Protein
Argininosuccinate synthase
Gene
argG, lpg0494
Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901Citrulline By similarity
Binding sitei119 – 1191ATP; via amide nitrogen By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei129 – 1291Citrulline By similarity
Binding sitei178 – 1781Citrulline By similarity
Binding sitei187 – 1871Citrulline By similarity
Binding sitei263 – 2631Citrulline By similarity
Binding sitei275 – 2751Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-494-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:lpg0494
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000609: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Argininosuccinate synthaseUniRule annotation
PRO_0000148604Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272624.lpg0494.

Structurei

3D structure databases

ProteinModelPortaliQ5ZY78.
SMRiQ5ZY78. Positions 7-400.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZY78-1 [UniParc]FASTAAdd to Basket

« Hide

MKKVIKKIAL AYSGGLDTSI MIPWLKEHYE HAEVIAVICD LGQQEDLDAI    50
KNKALKSGAS KAYVVDVKNE FATQYLWPLV KSGALYEDQY ILGTISRPLI 100
AQKLVEIALT EQVNAVAHGA TGKGNDQVRF EYSIKALAPQ LEIIAPWRTW 150
DIKSRQEAIV YAKAHGIEVP VTPKAPYSRD HNIWYISHEG GVLEDPSQEM 200
PNDVLLMTAP VSQTPDEEEV VVLDFKKGVP VALNGQELSP VDLLNSLNQK 250
AGQHGIGVAD IVENRLVGMK IRGIYEAPAA AVLYKAHKLL ESLCLTRSTL 300
HLKQSLQQTY ANLVYEGRWF SQTKQALDAF IDVTQQHVTG CVKLKLFKGN 350
IIPAGMHSPY SLHHPELATF EEDNVYNQKD AEGFINLFSL SAKIYSQVHQ 400
GGNYD 405
Length:405
Mass (Da):44,985
Last modified:November 23, 2004 - v1
Checksum:i6A76E7D62947DC56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017354 Genomic DNA. Translation: AAU26591.1.
RefSeqiYP_007569266.1. NC_020521.1.
YP_094538.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU26591; AAU26591; lpg0494.
GeneIDi14801415.
3079765.
KEGGilpn:lpg0494.
lpu:LPE509_02723.
PATRICi22327956. VBILegPne29832_0515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017354 Genomic DNA. Translation: AAU26591.1 .
RefSeqi YP_007569266.1. NC_020521.1.
YP_094538.1. NC_002942.5.

3D structure databases

ProteinModelPortali Q5ZY78.
SMRi Q5ZY78. Positions 7-400.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272624.lpg0494.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU26591 ; AAU26591 ; lpg0494 .
GeneIDi 14801415.
3079765.
KEGGi lpn:lpg0494.
lpu:LPE509_02723.
PATRICi 22327956. VBILegPne29832_0515.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci LPNE272624:GHDI-494-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

Entry informationi

Entry nameiASSY_LEGPH
AccessioniPrimary (citable) accession number: Q5ZY78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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