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Q5ZXH2 (G6PI_LEGPH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:lpg0759
OrganismLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]
Taxonomic identifier272624 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence AAU26848.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180664

Sites

Active site3521Proton donor By similarity
Active site3831 By similarity
Active site4871 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZXH2 [UniParc].

Last modified March 29, 2005. Version 2.
Checksum: 9049F98135DA80EB

FASTA49956,152
        10         20         30         40         50         60 
MIRNSMKSHT ELLSWNLLQK EADRVRLNSD SLTCVVPDSN NYESSKQINC IEYDYSRQRV 

        70         80         90        100        110        120 
NRTIIDLLID LANEVKLQEK IDNLINGKKI NISENRPALH TALRDLGNKS IMIDGLDIMS 

       130        140        150        160        170        180 
AVINTREKIK VISNQIREKK WLGHSGLPIT DIVNIGIGGS DLGPRVCINA LSNYISKEFN 

       190        200        210        220        230        240 
YHFISDVDPA SFNDVIAKIN PQTTLFIVSS KSFTTKETLL NARKAFALYE DTASIDQHFI 

       250        260        270        280        290        300 
AVTAHPERAY QMGIKTVLPI WDWVGGRFSF CSAVNLITAI AIGYEQFVEL LAGAHDVDTH 

       310        320        330        340        350        360 
VQFTDFKNNI PVLMALIGIW NNNFLNIHNL LILTYSKKLE YFVPYVQQLD MESNGKSIDV 

       370        380        390        400        410        420 
NGSMVDYATG PIVWGGLGNQ AQHSYFQLLC QGTHRCVGDF ITLKTNDEHE INSMCHYKMK 

       430        440        450        460        470        480 
VLSEGIQTIE NPYGYIPGNM PMNHLILSDC SPYTLGALVA LYEHKIFVQS VIWNINPFDQ 

       490 
PGIESAKSAH REITLSSES 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017354 Genomic DNA. Translation: AAU26848.1. Different initiation.
RefSeqYP_094795.1. NC_002942.5.

3D structure databases

ProteinModelPortalQ5ZXH2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272624.lpg0759.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU26848; AAU26848; lpg0759.
GeneID3080069.
KEGGlpn:lpg0759.
PATRIC22328508. VBILegPne29832_0784.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OMANCHFVAN.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycLPNE272624:GHDI-758-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_LEGPH
AccessionPrimary (citable) accession number: Q5ZXH2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways