L-serine dehydratase (Iron, sulfur-dependent) - Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

Preferred order of sections

Names and origin

Protein names

Submitted name:
L-serine dehydratase (Iron, sulfur-dependent) EMBL AAU26879.1
EC=4.3.1.17 EMBL AAU26879.1

Gene names

Name:	sda-2 EMBL AAU26879.1
Ordered Locus Names:	lpg0790

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Magnesium PDB 2IQQ Metal-binding PDB 2IQQ
Molecular function	Lyase EMBL AAU26879.1
Technical term	3D-structure PDB 2IQQ Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: InterPro
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: InterPro L-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

92

1

Magnesium; via carbonyl oxygen PDB 2IQQ

Metal binding

93

1

Magnesium PDB 2IQQ

Metal binding

95

1

Magnesium PDB 2IQQ

Sequences

Sequence

Length

Mass (Da)

Tools

Q5ZXE1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 5C163B51C9B441B5
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FASTA

458

49,462

        10         20         30         40         50         60 
MNISVFDLFS IGIGPSSSHT VGPMLAANAF LQLLEQKNLF DKTQRVKVEL YGSLALTGKG 

        70         80         90        100        110        120 
HGTDKAILNG LENKAPETVD PASMIPRMHE ILDSNLLNLA GKKEIPFHEA TDFLFLQKEL 

       130        140        150        160        170        180 
LPKHSNGMRF SAFDGNANLL IEQVYYSIGG GFITTEEDFD KSTTDTNPPP YPFATATELL 

       190        200        210        220        230        240 
KLCKKHHLTI AELMLVNEKT WRSSAEIHKG ILDIAKVMDD CINNGCKHDG VLPGGLNLKR 

       250        260        270        280        290        300 
RAPDLYRKLI EQKGVKSVFE QSDIMNHLNL YAMAVNEENA AGGRIVTAPT NGAAGIIPAV 

       310        320        330        340        350        360 
LKYCQQAHDR MSNEDIYTYF LTAAAIGILY KKGASISGAE VGCQGEVGVA SSMAAAGLTA 

       370        380        390        400        410        420 
VLGGTIEQVE NAAEIAMEHH LGMTCDPVLG LVQIPCIERN AMGAVKAVNA TRMALIGDGQ 

       430        440        450 
HQISLDKVIK TMKQTGMDMQ SIYKETSMGG LAVNLPEC

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. Russo J.J. Science 305:1966-1968(2004) [PubMed: 15448271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The Crystal Structure of Iron, Sulfur-Dependent L-serine dehydratase from Legionella pneumophila subsp. pneumophila." Kim Y., Hatzos C., Moy S., Joachimiak A. Submitted (OCT-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.66 ANGSTROMS) OF 4-161 IN COMPLEX WITH MAGNESIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE017354 Genomic DNA. Translation: AAU26879.1.

RefSeq

YP_094826.1. NC_002942.5.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2IQQ	X-ray	2.66	A/B	4-161	[»]

ProteinModelPortal

Q5ZXE1.

SMR

Q5ZXE1. Positions 17-161.

ModBase

Search...

Protein-protein interaction databases

STRING

Q5ZXE1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

3080598.

GenomeReviews

Gene locus lpg0790 in contig AE017354_GR.

KEGG

lpn:lpg0790.

PATRIC

22328576. VBILegPne29832_0818.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG1760.

HOGENOM

HBG304565.

OMA

GEHSIAF.

ProtClustDB

CLSK832410.

Family and domain databases

InterPro

IPR004644. Fe-S_L-Ser_mono.
IPR005130. Ser_deHydtase-like_asu.
IPR005131. Ser_deHydtase_bsu.
[Graphical view]

KO

K01752.

Pfam

PF03313. SDH_alpha. 1 hit.
PF03315. SDH_beta. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00720. Sda_mono. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q5ZXE1_LEGPH

Accession

Primary (citable) accession number: Q5ZXE1

Entry history

Integrated into UniProtKB/TrEMBL:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)