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Protein

Outer membrane protein MIP

Gene

mip

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Strongly inhibited by FK506 but is completely resistant to cyclosporin A.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein MIP (EC:5.2.1.8)
Alternative name(s):
Macrophage infectivity potentiator
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:mip
Ordered Locus Names:lpg0791
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000000609 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000002553321 – 233Outer membrane protein MIPAdd BLAST213

Proteomic databases

PaxDbiQ5ZXE0.

Interactioni

Protein-protein interaction databases

STRINGi272624.lpg0791.

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 49Combined sources20
Helixi55 – 67Combined sources13
Helixi75 – 117Combined sources43
Beta strandi121 – 123Combined sources3
Beta strandi129 – 134Combined sources6
Beta strandi146 – 155Combined sources10
Beta strandi160 – 163Combined sources4
Helixi164 – 167Combined sources4
Beta strandi171 – 174Combined sources4
Helixi175 – 177Combined sources3
Helixi180 – 186Combined sources7
Beta strandi194 – 199Combined sources6
Helixi201 – 203Combined sources3
Turni204 – 207Combined sources4
Beta strandi211 – 213Combined sources3
Beta strandi220 – 230Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FD9X-ray2.41A21-233[»]
2UZ5NMR-A97-233[»]
2VCDNMR-A97-233[»]
ProteinModelPortaliQ5ZXE0.
SMRiQ5ZXE0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5ZXE0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 233PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST90

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108V1T. Bacteria.
COG0545. LUCA.
HOGENOMiHOG000154888.
KOiK03773.

Family and domain databases

Gene3Di1.10.287.460. 1 hit.
InterProiIPR008104. INFPOTNTIATR.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR000774. PPIase_FKBP_N.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00254. FKBP_C. 1 hit.
PF01346. FKBP_N. 1 hit.
[Graphical view]
PRINTSiPR01730. INFPOTNTIATR.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZXE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMKLVTAAV MGLAMSTAMA ATDATSLATD KDKLSYSIGA DLGKNFKNQG
60 70 80 90 100
IDVNPEAMAK GMQDAMSGAQ LALTEQQMKD VLNKFQKDLM AKRTAEFNKK
110 120 130 140 150
ADENKVKGEA FLTENKNKPG VVVLPSGLQY KVINSGNGVK PGKSDTVTVE
160 170 180 190 200
YTGRLIDGTV FDSTEKTGKP ATFQVSQVIP GWTEALQLMP AGSTWEIYVP
210 220 230
SGLAYGPRSV GGPIGPNETL IFKIHLISVK KSS
Length:233
Mass (Da):24,881
Last modified:February 1, 2005 - v2
Checksum:i6FF95CBCF464CD5A
GO

Sequence cautioni

The sequence AAU26880 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S42595 Genomic DNA. Translation: AAB22717.1.
AE017354 Genomic DNA. Translation: AAU26880.1. Different initiation.
RefSeqiWP_010946528.1. NC_002942.5.
YP_094827.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU26880; AAU26880; lpg0791.
GeneIDi19832357.
KEGGilpn:lpg0791.
PATRICi22328578. VBILegPne29832_0819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S42595 Genomic DNA. Translation: AAB22717.1.
AE017354 Genomic DNA. Translation: AAU26880.1. Different initiation.
RefSeqiWP_010946528.1. NC_002942.5.
YP_094827.1. NC_002942.5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FD9X-ray2.41A21-233[»]
2UZ5NMR-A97-233[»]
2VCDNMR-A97-233[»]
ProteinModelPortaliQ5ZXE0.
SMRiQ5ZXE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272624.lpg0791.

Proteomic databases

PaxDbiQ5ZXE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU26880; AAU26880; lpg0791.
GeneIDi19832357.
KEGGilpn:lpg0791.
PATRICi22328578. VBILegPne29832_0819.

Phylogenomic databases

eggNOGiENOG4108V1T. Bacteria.
COG0545. LUCA.
HOGENOMiHOG000154888.
KOiK03773.

Miscellaneous databases

EvolutionaryTraceiQ5ZXE0.

Family and domain databases

Gene3Di1.10.287.460. 1 hit.
InterProiIPR008104. INFPOTNTIATR.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR000774. PPIase_FKBP_N.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00254. FKBP_C. 1 hit.
PF01346. FKBP_N. 1 hit.
[Graphical view]
PRINTSiPR01730. INFPOTNTIATR.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIP_LEGPH
AccessioniPrimary (citable) accession number: Q5ZXE0
Secondary accession number(s): P20380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.