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Q5ZXE0

- MIP_LEGPH

UniProt

Q5ZXE0 - MIP_LEGPH

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Protein

Outer membrane protein MIP

Gene

mip

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Strongly inhibited by FK506 but is completely resistant to cyclosporin A.

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-790-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein MIP (EC:5.2.1.8)
Alternative name(s):
Macrophage infectivity potentiator
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:mip
Ordered Locus Names:lpg0791
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000609: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 233213Outer membrane protein MIPPRO_0000025533Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272624.lpg0791.

Structurei

Secondary structure

1
233
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 4920
Helixi55 – 6713
Helixi75 – 11743
Beta strandi121 – 1233
Beta strandi129 – 1346
Beta strandi146 – 15510
Beta strandi160 – 1634
Helixi164 – 1674
Beta strandi171 – 1744
Helixi175 – 1773
Helixi180 – 1867
Beta strandi194 – 1996
Helixi201 – 2033
Turni204 – 2074
Beta strandi211 – 2133
Beta strandi220 – 23011

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FD9X-ray2.41A21-233[»]
2UZ5NMR-A97-233[»]
2VCDNMR-A97-233[»]
ProteinModelPortaliQ5ZXE0.
SMRiQ5ZXE0. Positions 29-232.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5ZXE0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini144 – 23390PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154888.
KOiK03773.
OrthoDBiEOG6DRPKW.

Family and domain databases

Gene3Di1.10.287.460. 1 hit.
InterProiIPR008104. INFPOTNTIATR.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR000774. PPIase_FKBP_N.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
PF01346. FKBP_N. 1 hit.
[Graphical view]
PRINTSiPR01730. INFPOTNTIATR.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZXE0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMKLVTAAV MGLAMSTAMA ATDATSLATD KDKLSYSIGA DLGKNFKNQG
60 70 80 90 100
IDVNPEAMAK GMQDAMSGAQ LALTEQQMKD VLNKFQKDLM AKRTAEFNKK
110 120 130 140 150
ADENKVKGEA FLTENKNKPG VVVLPSGLQY KVINSGNGVK PGKSDTVTVE
160 170 180 190 200
YTGRLIDGTV FDSTEKTGKP ATFQVSQVIP GWTEALQLMP AGSTWEIYVP
210 220 230
SGLAYGPRSV GGPIGPNETL IFKIHLISVK KSS
Length:233
Mass (Da):24,881
Last modified:February 1, 2005 - v2
Checksum:i6FF95CBCF464CD5A
GO

Sequence cautioni

The sequence AAU26880.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S42595 Genomic DNA. Translation: AAB22717.1.
AE017354 Genomic DNA. Translation: AAU26880.1. Different initiation.
RefSeqiYP_094827.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU26880; AAU26880; lpg0791.
GeneIDi19832357.
KEGGilpn:lpg0791.
lpu:LPE509_02423.
PATRICi22328578. VBILegPne29832_0819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S42595 Genomic DNA. Translation: AAB22717.1 .
AE017354 Genomic DNA. Translation: AAU26880.1 . Different initiation.
RefSeqi YP_094827.1. NC_002942.5.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FD9 X-ray 2.41 A 21-233 [» ]
2UZ5 NMR - A 97-233 [» ]
2VCD NMR - A 97-233 [» ]
ProteinModelPortali Q5ZXE0.
SMRi Q5ZXE0. Positions 29-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272624.lpg0791.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU26880 ; AAU26880 ; lpg0791 .
GeneIDi 19832357.
KEGGi lpn:lpg0791.
lpu:LPE509_02423.
PATRICi 22328578. VBILegPne29832_0819.

Phylogenomic databases

eggNOGi COG0545.
HOGENOMi HOG000154888.
KOi K03773.
OrthoDBi EOG6DRPKW.

Enzyme and pathway databases

BioCyci LPNE272624:GHDI-790-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5ZXE0.

Family and domain databases

Gene3Di 1.10.287.460. 1 hit.
InterProi IPR008104. INFPOTNTIATR.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR000774. PPIase_FKBP_N.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
PF01346. FKBP_N. 1 hit.
[Graphical view ]
PRINTSi PR01730. INFPOTNTIATR.
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity."
    Fischer G., Bang H., Ludwig B., Mann K., Hacker J.
    Mol. Microbiol. 6:1375-1383(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 21-40, PPIASE ACTIVITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 21-233.

Entry informationi

Entry nameiMIP_LEGPH
AccessioniPrimary (citable) accession number: Q5ZXE0
Secondary accession number(s): P20380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3