Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5ZXE0

- MIP_LEGPH

UniProt

Q5ZXE0 - MIP_LEGPH

Protein

Outer membrane protein MIP

Gene

mip

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Strongly inhibited by FK506 but is completely resistant to cyclosporin A.

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Biological processi

    Virulence

    Enzyme and pathway databases

    BioCyciLPNE272624:GHDI-790-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer membrane protein MIP (EC:5.2.1.8)
    Alternative name(s):
    Macrophage infectivity potentiator
    Peptidyl-prolyl cis-trans isomerase
    Short name:
    PPIase
    Rotamase
    Gene namesi
    Name:mip
    Ordered Locus Names:lpg0791
    OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
    Taxonomic identifieri272624 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000000609: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 233213Outer membrane protein MIPPRO_0000025533Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272624.lpg0791.

    Structurei

    Secondary structure

    1
    233
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi30 – 4920
    Helixi55 – 6713
    Helixi75 – 11743
    Beta strandi121 – 1233
    Beta strandi129 – 1346
    Beta strandi146 – 15510
    Beta strandi160 – 1634
    Helixi164 – 1674
    Beta strandi171 – 1744
    Helixi175 – 1773
    Helixi180 – 1867
    Beta strandi194 – 1996
    Helixi201 – 2033
    Turni204 – 2074
    Beta strandi211 – 2133
    Beta strandi220 – 23011

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FD9X-ray2.41A21-233[»]
    2UZ5NMR-A97-233[»]
    2VCDNMR-A97-233[»]
    ProteinModelPortaliQ5ZXE0.
    SMRiQ5ZXE0. Positions 29-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5ZXE0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini144 – 23390PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family.Curated
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000154888.
    KOiK03773.
    OrthoDBiEOG6DRPKW.

    Family and domain databases

    Gene3Di1.10.287.460. 1 hit.
    InterProiIPR008104. INFPOTNTIATR.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR000774. PPIase_FKBP_N.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    PF01346. FKBP_N. 1 hit.
    [Graphical view]
    PRINTSiPR01730. INFPOTNTIATR.
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5ZXE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKMKLVTAAV MGLAMSTAMA ATDATSLATD KDKLSYSIGA DLGKNFKNQG    50
    IDVNPEAMAK GMQDAMSGAQ LALTEQQMKD VLNKFQKDLM AKRTAEFNKK 100
    ADENKVKGEA FLTENKNKPG VVVLPSGLQY KVINSGNGVK PGKSDTVTVE 150
    YTGRLIDGTV FDSTEKTGKP ATFQVSQVIP GWTEALQLMP AGSTWEIYVP 200
    SGLAYGPRSV GGPIGPNETL IFKIHLISVK KSS 233
    Length:233
    Mass (Da):24,881
    Last modified:February 1, 2005 - v2
    Checksum:i6FF95CBCF464CD5A
    GO

    Sequence cautioni

    The sequence AAU26880.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S42595 Genomic DNA. Translation: AAB22717.1.
    AE017354 Genomic DNA. Translation: AAU26880.1. Different initiation.
    RefSeqiWP_011213317.1. NC_020521.1.
    YP_007568966.1. NC_020521.1.
    YP_094827.1. NC_002942.5.

    Genome annotation databases

    EnsemblBacteriaiAAU26880; AAU26880; lpg0791.
    GeneIDi14801115.
    3078495.
    KEGGilpn:lpg0791.
    lpu:LPE509_02423.
    PATRICi22328578. VBILegPne29832_0819.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S42595 Genomic DNA. Translation: AAB22717.1 .
    AE017354 Genomic DNA. Translation: AAU26880.1 . Different initiation.
    RefSeqi WP_011213317.1. NC_020521.1.
    YP_007568966.1. NC_020521.1.
    YP_094827.1. NC_002942.5.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FD9 X-ray 2.41 A 21-233 [» ]
    2UZ5 NMR - A 97-233 [» ]
    2VCD NMR - A 97-233 [» ]
    ProteinModelPortali Q5ZXE0.
    SMRi Q5ZXE0. Positions 29-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272624.lpg0791.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU26880 ; AAU26880 ; lpg0791 .
    GeneIDi 14801115.
    3078495.
    KEGGi lpn:lpg0791.
    lpu:LPE509_02423.
    PATRICi 22328578. VBILegPne29832_0819.

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000154888.
    KOi K03773.
    OrthoDBi EOG6DRPKW.

    Enzyme and pathway databases

    BioCyci LPNE272624:GHDI-790-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5ZXE0.

    Family and domain databases

    Gene3Di 1.10.287.460. 1 hit.
    InterProi IPR008104. INFPOTNTIATR.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR000774. PPIase_FKBP_N.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    PF01346. FKBP_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01730. INFPOTNTIATR.
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity."
      Fischer G., Bang H., Ludwig B., Mann K., Hacker J.
      Mol. Microbiol. 6:1375-1383(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 21-40, PPIASE ACTIVITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 21-233.

    Entry informationi

    Entry nameiMIP_LEGPH
    AccessioniPrimary (citable) accession number: Q5ZXE0
    Secondary accession number(s): P20380
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3