Reviewed, UniProtKB/Swiss-Prot Q5ZX76 (CCMA_LEGPH)

Names and origin

Protein names

Recommended name:
    Cytochrome c biogenesis ATP-binding export protein ccmA
    EC=3.6.3.41
Alternative name(s):
    Heme exporter protein A

Gene names

Name:	ccmA
Ordered Locus Names:	lpg0856

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the ABC transporter complex ccmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01707
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (ccmA) and two transmembrane proteins (ccmB) Probable. HAMAP MF_01707
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01707.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: HAMAP
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	Cytochrome c biogenesis ATP-binding export protein ccmA HAMAP MF_01707		PRO_0000092185
Regions
	Domain	2 – 200	199	ABC transporter
	Nucleotide binding	34 – 41	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5ZX76-1 [UniParc]. Last modified March 15, 2005. Version 2. Checksum: CE1655B375D8B479	FASTA	200	22,557
	10 20 30 40 50 60 MLDVIELDFD YHDQPLLQQI SFHLPAGGLL HLKGSNGAGK TTLLKLIAGL LNPEKGEILF 70 80 90 100 110 120 ERQSIKKDLC TYQKQLCFVG HRSGINPYLT LRENCLYDIH FSPGAVGITE LCRLFSLEHL 130 140 150 160 170 180 IDYPCGLLSS GQKRQVALLR LWMSKAKLWL LDEPLVALDE LSLLTIITKI QEHRAKGGAV 190 200 LLTSHQDLPL NKADYEEYHL

References

[1]

"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J. Science 305:1966-1968(2004) [PubMed: 15448271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017354 Genomic DNA. Translation: AAU26944.1. Different initiation.
RefSeq	YP_094891.2.
3D structure databases
SMR	Q5ZX76. Positions 3-186.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZX76.
Genome annotation databases
GeneID	3079879.
GenomeReviews	Gene locus lpg0856 in contig AE017354_GR.
KEGG	lpn:lpg0856.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4133.
HOGENOM	HBG758042.
Enzyme and pathway databases
BioCyc	LPNE272624:LPG0856-MONOMER.
Family and domain databases
HAMAP	MF_01707. ABC_ATPase_CcmA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
PANTHER	PTHR19222:SF5. CcmA. 1 hit.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. ccmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. False negative. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_LEGPH

Accession

Primary (citable) accession number: Q5ZX76

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	February 9, 2010
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)