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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991SubstrateUniRule annotation
Active sitei108 – 1081Proton acceptorUniRule annotation
Metal bindingi129 – 1291Monovalent cationUniRule annotation
Binding sitei132 – 1321ATPUniRule annotation
Binding sitei184 – 1841SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 138ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-910-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:lpg0911
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000000609 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Type III pantothenate kinasePRO_0000267553Add
BLAST

Proteomic databases

PaxDbiQ5ZX22.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272624.lpg0911.

Structurei

Secondary structure

1
256
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Beta strandi9 – 1810Combined sources
Beta strandi21 – 299Combined sources
Helixi35 – 4713Combined sources
Turni48 – 503Combined sources
Helixi53 – 553Combined sources
Beta strandi58 – 647Combined sources
Helixi66 – 7914Combined sources
Beta strandi89 – 913Combined sources
Helixi102 – 1043Combined sources
Helixi107 – 11913Combined sources
Beta strandi123 – 13917Combined sources
Beta strandi143 – 15210Combined sources
Helixi154 – 16310Combined sources
Beta strandi181 – 1833Combined sources
Helixi184 – 21027Combined sources
Turni211 – 2144Combined sources
Beta strandi217 – 2237Combined sources
Helixi226 – 2294Combined sources
Turni230 – 2334Combined sources
Beta strandi236 – 2383Combined sources
Helixi242 – 25211Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DJCX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L2-256[»]
ProteinModelPortaliQ5ZX22.
SMRiQ5ZX22. Positions 1-256.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5ZX22.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1094Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108194. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066025.
KOiK03525.
OMAiHEPWLTL.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZX22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILCIDVGNS HIYGGVFDGD EIKLRFRHTS KVSTSDELGI FLKSVLRENN
60 70 80 90 100
CSPETIRKIA ICSVVPQVDY SLRSACVKYF SIDPFLLQAG VKTGLNIKYR
110 120 130 140 150
NPVEVGADRI ANAIAATHSF PNQNIIVIDF GTATTFCAIS HKKAYLGGAI
160 170 180 190 200
LPGLRLSADA LSKNTAKLPS VEIIKTESVV GRSTIESIQS GVYYGVLGAC
210 220 230 240 250
KELIQRIHHE AFNGDQILIL ATGGFASLFD KQGLYDHLVP DLVLQGIRLA

AMMNTA
Length:256
Mass (Da):27,744
Last modified:November 23, 2004 - v1
Checksum:i1D9D254FBD6180A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU26998.1.
RefSeqiWP_010946646.1. NC_002942.5.
YP_094945.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU26998; AAU26998; lpg0911.
GeneIDi19832477.
KEGGilpn:lpg0911.
PATRICi22328832. VBILegPne29832_0944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU26998.1.
RefSeqiWP_010946646.1. NC_002942.5.
YP_094945.1. NC_002942.5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DJCX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L2-256[»]
ProteinModelPortaliQ5ZX22.
SMRiQ5ZX22. Positions 1-256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272624.lpg0911.

Proteomic databases

PaxDbiQ5ZX22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU26998; AAU26998; lpg0911.
GeneIDi19832477.
KEGGilpn:lpg0911.
PATRICi22328832. VBILegPne29832_0944.

Phylogenomic databases

eggNOGiENOG4108194. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066025.
KOiK03525.
OMAiHEPWLTL.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciLPNE272624:GHDI-910-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5ZX22.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAX_LEGPH
AccessioniPrimary (citable) accession number: Q5ZX22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.