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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99SubstrateUniRule annotation1
Active sitei108Proton acceptorUniRule annotation1
Metal bindingi129Monovalent cationUniRule annotation1
Binding sitei132ATPUniRule annotation1
Binding sitei184SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 13ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:lpg0911
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000000609 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002675531 – 256Type III pantothenate kinaseAdd BLAST256

Proteomic databases

PaxDbiQ5ZX22.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272624.lpg0911.

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Beta strandi9 – 18Combined sources10
Beta strandi21 – 29Combined sources9
Helixi35 – 47Combined sources13
Turni48 – 50Combined sources3
Helixi53 – 55Combined sources3
Beta strandi58 – 64Combined sources7
Helixi66 – 79Combined sources14
Beta strandi89 – 91Combined sources3
Helixi102 – 104Combined sources3
Helixi107 – 119Combined sources13
Beta strandi123 – 139Combined sources17
Beta strandi143 – 152Combined sources10
Helixi154 – 163Combined sources10
Beta strandi181 – 183Combined sources3
Helixi184 – 210Combined sources27
Turni211 – 214Combined sources4
Beta strandi217 – 223Combined sources7
Helixi226 – 229Combined sources4
Turni230 – 233Combined sources4
Beta strandi236 – 238Combined sources3
Helixi242 – 252Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DJCX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L2-256[»]
ProteinModelPortaliQ5ZX22.
SMRiQ5ZX22.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5ZX22.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 109Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108194. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066025.
KOiK03525.
OMAiHEPWLTL.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZX22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILCIDVGNS HIYGGVFDGD EIKLRFRHTS KVSTSDELGI FLKSVLRENN
60 70 80 90 100
CSPETIRKIA ICSVVPQVDY SLRSACVKYF SIDPFLLQAG VKTGLNIKYR
110 120 130 140 150
NPVEVGADRI ANAIAATHSF PNQNIIVIDF GTATTFCAIS HKKAYLGGAI
160 170 180 190 200
LPGLRLSADA LSKNTAKLPS VEIIKTESVV GRSTIESIQS GVYYGVLGAC
210 220 230 240 250
KELIQRIHHE AFNGDQILIL ATGGFASLFD KQGLYDHLVP DLVLQGIRLA

AMMNTA
Length:256
Mass (Da):27,744
Last modified:November 23, 2004 - v1
Checksum:i1D9D254FBD6180A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU26998.1.
RefSeqiWP_010946646.1. NC_002942.5.
YP_094945.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU26998; AAU26998; lpg0911.
GeneIDi19832477.
KEGGilpn:lpg0911.
PATRICi22328832. VBILegPne29832_0944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU26998.1.
RefSeqiWP_010946646.1. NC_002942.5.
YP_094945.1. NC_002942.5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DJCX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L2-256[»]
ProteinModelPortaliQ5ZX22.
SMRiQ5ZX22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272624.lpg0911.

Proteomic databases

PaxDbiQ5ZX22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU26998; AAU26998; lpg0911.
GeneIDi19832477.
KEGGilpn:lpg0911.
PATRICi22328832. VBILegPne29832_0944.

Phylogenomic databases

eggNOGiENOG4108194. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066025.
KOiK03525.
OMAiHEPWLTL.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Miscellaneous databases

EvolutionaryTraceiQ5ZX22.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAX_LEGPH
AccessioniPrimary (citable) accession number: Q5ZX22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.