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Q5ZWN7 (ATPA1_LEGPH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP synthase subunit alpha 1
EC=3.6.3.14
Alternative name(s):
ATP synthase F1 sector subunit alpha 1
F-ATPase subunit alpha 1
Gene names
Name:atpA1
Ordered Locus Names:lpg1048
OrganismLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]
Taxonomic identifier272624 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP MF_01346

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01346.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490ATP synthase subunit alpha 1 HAMAP MF_01346
PRO_0000238272

Sites

Site3641Required for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZWN7 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: FAA3FCA1BC7D1AD9

FASTA49054,851
        10         20         30         40         50         60 
MNWSNTPSFL EKQRQRLERY QFQIKVSEQG RVVSVGDGII WIKGLPGAAI DEILISEDEC 

        70         80         90        100        110        120 
CIAMVFHLTE ELVGAVMLVQ TKKLKAGTPI FPLKRVLSIP VGDKLLGRVI DPLGHPLDGG 

       130        140        150        160        170        180 
EIPPHEEQGL LDRLSPPILH RDFVNRPLYT GNKMLDNLIP IGKGQRELLI GDNGLGKSAL 

       190        200        210        220        230        240 
ALDIVMNQKD KKVYCVYVLI GQKRSTVSST IQLLKEANAL DYTTVVVAQA TALPGLLYLA 

       250        260        270        280        290        300 
PFAGCAIAEH WMKKGLDALV IYDDLSAHAN SYRELSLLLR RPPGREAFPA DIFYLHSRLL 

       310        320        330        340        350        360 
ERSTCLSPAL GGGSMTALPI IETKEGEMAT YIPTNLISIT DGQIFFDESL FSSGFLPAID 

       370        380        390        400        410        420 
ITKSVSRVGG KAQHPQIKKE SGRMKLDYLQ FLDLELFTRF GAKLDAKMQK QIQKGRVLRE 

       430        440        450        460        470        480 
ILKQERFSPL PIEFQLAWLI AYNEGFFDEL NLEDIPKMLK KIEEEIKQST LSLGSPREQW 

       490 
KKAIKEWLMA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017354 Genomic DNA. Translation: AAU27134.1.
RefSeqYP_095081.1. NC_002942.5.

3D structure databases

ProteinModelPortalQ5ZWN7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5ZWN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3080316.
GenomeReviewsGene locus lpg1048 in contig AE017354_GR.
KEGGlpn:lpg1048.
PATRIC22329124. VBILegPne29832_1088.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0056.
HOGENOMHBG565875.
OMAHAQTYRE.
ProtClustDBPRK13343.

Enzyme and pathway databases

BioCycLPNE272624:LPG1048-MONOMER.

Family and domain databases

HAMAPMF_01346. ATP_synth_alpha_bact.
[Tree]
InterProIPR020003. ATPase_a/bsu_AS.
IPR005294. ATPase_F1-cplx_asu.
IPR018118. ATPase_F1/A1-cplx_a/bsu_N.
IPR023366. ATPase_F1/A1-cplx_a_su_N.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
[Graphical view]
Gene3DG3DSA:2.40.30.20. G3DSA:2.40.30.20. 1 hit.
KOK02111.
PANTHERPTHR15184:SF3. ATPase_F1_a. 1 hit.
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
[Graphical view]
SUPFAMSSF47917. ATPase_a/b_C. 1 hit.
SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMsTIGR00962. AtpA. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATPA1_LEGPH
AccessionPrimary (citable) accession number: Q5ZWN7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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