ID   Q5ZWF5_LEGPH            Unreviewed;       483 AA.
AC   Q5ZWF5;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:AAU27216.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:AAU27216.1};
GN   Name=cyaA4 {ECO:0000313|EMBL:AAU27216.1};
GN   OrderedLocusNames=lpg1130 {ECO:0000313|EMBL:AAU27216.1};
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS   33152 / DSM 7513).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU27216.1, ECO:0000313|Proteomes:UP000000609};
RN   [1] {ECO:0000313|EMBL:AAU27216.1, ECO:0000313|Proteomes:UP000000609}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC   {ECO:0000313|Proteomes:UP000000609};
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA   Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA   Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA   Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA   Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA   Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA   Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL   Science 305:1966-1968(2004).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017354; AAU27216.1; -; Genomic_DNA.
DR   RefSeq; WP_010946864.1; NC_002942.5.
DR   RefSeq; YP_095163.1; NC_002942.5.
DR   AlphaFoldDB; Q5ZWF5; -.
DR   STRING; 272624.lpg1130; -.
DR   PaxDb; 272624-lpg1130; -.
DR   GeneID; 66490306; -.
DR   KEGG; lpn:lpg1130; -.
DR   PATRIC; fig|272624.6.peg.1187; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG2972; Bacteria.
DR   HOGENOM; CLU_544829_0_0_6; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000000609; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:AAU27216.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000609};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        193..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          218..270
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          304..436
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   483 AA;  54667 MW;  4B44C0DFF3ABD4B3 CRC64;
     MKFRTKLFLG LLLIVITTNG IFLFLSYQYG KETVYKEVGS SALSIAAATA VLMNPEDIQK
     FNLDTSANSP LYKDLEKKLL EVRNANRRKD VYVNFIYSLF PDSNNPKVLR FAVDPEENTI
     DKTELGTVMK LKTESGQTIN VNYESPIVLP EFVEDIWGTW LTALYPIKDA QGKYLGNIRV
     DVDADSVNQR FHFLLYSGIA VFISTFLFAI FLGWLLFQWF NKPLLKITTA LKNIAQGDLE
     QHLDIRTKDE FAEVGRVINE MTEGLRQRNM LQVSLTRFIS HALAEKIVKS GELPQVFSER
     RKVTIMVCDI RDFTTISERI KPELVVDFLN HFFEKMIEAI TSQHGILDKY LGDGFLAIFG
     SPDDDAYQED HAIHAALKMR EAMKSLNADW AKILGSEIQI GIGINTGSAI VGNIGTDIHM
     EYTAIGDTVN LASRIENATK KLNTDILISE YTYIATDHTA FQFIELGEIS IKGRVHKVKV
     YTL
//