Reviewed, UniProtKB/Swiss-Prot Q5ZW88 (HIS81_LEGPH)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	lpg1198

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153381
Amino acid modifications
	Modified residue	211	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZW88-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 5A5070BF2BBB4319	FASTA	364	41,329
	10 20 30 40 50 60 MSILNLVRAD LLNSKNYVPG GESARYRSHA NELPWSPVTM GEHNLNYYPN IGLQIELQKQ 70 80 90 100 110 120 LAKRYQIYSD QIILTRGSDD GIDLTTRLFL TAGKDAFMQF PPTFPMYAFY VRLQQAELIE 130 140 150 160 170 180 CPLDRRTNFR LTLDQIENSW KPNCKIIMFC SPNNPTGNLV DLNLIAKTCE LYANQSIIVV 190 200 210 220 230 240 DEAYIEFANA PSATSLIGEF ENLIVLRTLS KAFGLAGLRL GCIIAQSPII QAFNKIIAPY 250 260 270 280 290 300 SIATPSMELA KRALNNSDWF TKTIEQIKSS RAWVIKKFAD NPIIEKIYPT ETNFILIQTR 310 320 330 340 350 360 FSKQLTTWLA HYGIAVRDFP SSSLLHDHLR ITVGHDEQNQ LLINTLSSFN ADVAGLNYEK DFIY

References

[1]

"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J. Science 305:1966-1968(2004) [PubMed: 15448271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017354 Genomic DNA. Translation: AAU27283.1.
RefSeq	YP_095230.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZW88.
Genome annotation databases
GeneID	3079005.
GenomeReviews	Gene locus lpg1198 in contig AE017354_GR.
KEGG	lpn:lpg1198.
NMPDR	fig|272624.3.peg.2217.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5ZW88.
OMA	RIQTIEH.
Enzyme and pathway databases
BioCyc	LPNE272624:LPG1198-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_LEGPH

Accession

Primary (citable) accession number: Q5ZW88

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)