Reviewed, UniProtKB/Swiss-Prot Q5ZW72 (HEM6_LEGPH)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen 3 oxidase, aerobic
    EC=1.3.3.3
Alternative name(s):
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase

Gene names

Name:	hemF
Ordered Locus Names:	lpg1215

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Coproporphyrinogen 3 oxidase, aerobic		PRO_0000109901

Sequences

	Sequence		Length	Mass (Da)
	Q5ZW72-1 [UniParc]. Last modified April 12, 2005. Version 2. Checksum: 24DA5D277CAC0B90	FASTA	311	35,820
	10 20 30 40 50 60 MPISKTLPYN AIEQIKSYLL QLQNTICVSL ESIDGKTRFH EDSWQRAAGG GGKTRIMANG 70 80 90 100 110 120 NVFEKAGVNF SHVSGEQLPA SASAHREELA GRHFSALGVS LVIHPQNPYV PTTHANVRFF 130 140 150 160 170 180 VAEKEDSEPV WWFGGGFDLT PYYGFVEDCE HWHQTALNAC LPFGETIYPK FKRWCDDYFF 190 200 210 220 230 240 IKHRNEARGI GGLFFDDYNE ISFDHSFELM RSIGDHFILA YEPIVARRKD IPFGNREKAF 250 260 270 280 290 300 QNYRRGRYAE FNLVYDRGTL FGLQSGGRTE SILMSLPPIV HWEYNWHPEK GSDEEKLYTD 310 FLPAKDWLKK E

References

[1]

"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J. Science 305:1966-1968(2004) [PubMed: 15448271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017354 Genomic DNA. Translation: AAU27299.1. Different initiation.
RefSeq	YP_095246.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3080091.
GenomeReviews	Gene locus lpg1215 in contig AE017354_GR.
KEGG	lpn:lpg1215.
NMPDR	fig|272624.3.peg.2393.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5ZW72.
Enzyme and pathway databases
BioCyc	LPNE272624:LPG1215-MON.
Family and domain databases
HAMAP	MF_00333. [Tree]
InterPro	IPR001260. Coprogen_oxidas. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM6_LEGPH

Accession

Primary (citable) accession number: Q5ZW72

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	April 12, 2005
Last modified:	November 4, 2008
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)