ID   Q5ZVW6_LEGPH            Unreviewed;       711 AA.
AC   Q5ZVW6;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   SubName: Full=Adenylate cyclase 1 protein {ECO:0000313|EMBL:AAU27405.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:AAU27405.1};
GN   Name=cyaA {ECO:0000313|EMBL:AAU27405.1};
GN   OrderedLocusNames=lpg1322 {ECO:0000313|EMBL:AAU27405.1};
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS   33152 / DSM 7513).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU27405.1, ECO:0000313|Proteomes:UP000000609};
RN   [1] {ECO:0000313|EMBL:AAU27405.1, ECO:0000313|Proteomes:UP000000609}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC   {ECO:0000313|Proteomes:UP000000609};
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA   Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA   Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA   Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA   Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA   Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA   Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL   Science 305:1966-1968(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AE017354; AAU27405.1; -; Genomic_DNA.
DR   RefSeq; YP_095352.1; NC_002942.5.
DR   AlphaFoldDB; Q5ZVW6; -.
DR   STRING; 272624.lpg1322; -.
DR   PaxDb; 272624-lpg1322; -.
DR   KEGG; lpn:lpg1322; -.
DR   PATRIC; fig|272624.6.peg.1390; -.
DR   eggNOG; COG2114; Bacteria.
DR   HOGENOM; CLU_021956_0_0_6; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000000609; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd12913; PDC1_MCP_like; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR033479; dCache_1.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF02743; dCache_1; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF103190; Sensory domain-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Lyase {ECO:0000313|EMBL:AAU27405.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000609};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          449..581
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   711 AA;  81174 MW;  D1476DBC9B470CED CRC64;
     MYFLQLEGKN MDSNFKISIR VSIITLFVLL LSLVGFTIIG INYIAFNSVL NSSAKDSIEQ
     TSLLVKERFE IYLNPLNQDL IKITNAINNG IINPDDSKQF DKFLFESIRY NPEIFMVYYG
     STTGDFIGVD REQKGIIGLT HVINSVSPPV NVRYQLNEQG EIIGKKLLTR HYDPRVRPWY
     QQAIKAGKPI WTNVYTFYVF DKSDFLIPGI TGASPIYNKN KQIKGVIALD LTIDGLQHFI
     RELELTKNTM IYVINNESNI IAFRTPQNKK DIRGKKLTPE WIKKLNIPLK KLDFNDFEPI
     IKSYTHDNQK YYLAYQPISS TNEKALWHII IIVPETDVIE PLKDLSMRYI LLTILVLLIG
     TLLVRIVSQR ISNPIIQLTE EAKEITMLNL KPRPLLKTRI KEVSYMDKTL SSLRSSLASF
     QRYVPGSLVK KLMRSGKIAQ VGGQSQTITI LFSDIKDFTS ISESTSPQKL MTYLSDYFQS
     MTEIVIQHEG TLDKYIGDAI MALWNAPSKD TNHSLHACLA AKIMIDRLSL LNQKNKHLGF
     PEFKIRIGIH TGDAVVGNVG SEDRLSYTAL GDSVNLASRL ESINKNYHTQ IIVSHATYTQ
     VSEKFPFRLL DEVAVRGKRE SIEIYELITA QNLENLERHK KEFQKAFSLY QKGSWKESIS
     AFAKLTPAYS DDQLASVYIE RCKVLAVNPP VNWDGIWREG KTDYSLLGKF D
//