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Q5ZVR9

- LPXB1_LEGPH

UniProt

Q5ZVR9 - LPXB1_LEGPH

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Protein

Lipid-A-disaccharide synthase 1

Gene
lpxB1, lpg1371
Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-1370-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase 1 (EC:2.4.1.182)
Gene namesi
Name:lpxB1
Ordered Locus Names:lpg1371
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000609: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Lipid-A-disaccharide synthase 1UniRule annotationPRO_0000255194Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272624.lpg1371.

Structurei

3D structure databases

ProteinModelPortaliQ5ZVR9.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiTIYENAG.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZVR9-1 [UniParc]FASTAAdd to Basket

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MPNASRVVIV AGEESGDHHA AELVKQLKAV YPDLEISGIG GKHLRAAGVH    50
LISDLTRYAV TGLTEIIPFL KIFRKAFQDI KQHLSTQKPD LLILVDYPAF 100
NLRLAKYAKK KLGIKIIYYI SPQIWAWKGK RIHLIKDCID KMAVIFPFEK 150
TIYENAGVPV SFVGHPLVKK IAAAKDKHSG RTSLGLPLNE PIIALLPGSR 200
HSEIERHIPI LVNTAKLLTL DNPKLRFVVP IAGTINPDKV KAYFSNQNLT 250
VTFIQGQAIE CMSAADFVIV ASGTASLECA LLEKPMCIIY KSSFLTYVAA 300
MYFIKVKFLG LCNLLANKMM VPEFLQYDCN AIELSRYISN FHNDPNQAKS 350
MINQLAKLKE SLSSSQADCS LFDLVVAELP EKNA 384
Length:384
Mass (Da):42,634
Last modified:November 23, 2004 - v1
Checksum:iBFC508AFCACD5372
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017354 Genomic DNA. Translation: AAU27453.1.
RefSeqiYP_095400.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU27453; AAU27453; lpg1371.
GeneIDi3080186.
KEGGilpn:lpg1371.
PATRICi22329836. VBILegPne29832_1441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017354 Genomic DNA. Translation: AAU27453.1 .
RefSeqi YP_095400.1. NC_002942.5.

3D structure databases

ProteinModelPortali Q5ZVR9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272624.lpg1371.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU27453 ; AAU27453 ; lpg1371 .
GeneIDi 3080186.
KEGGi lpn:lpg1371.
PATRICi 22329836. VBILegPne29832_1441.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi TIYENAG.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci LPNE272624:GHDI-1370-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

Entry informationi

Entry nameiLPXB1_LEGPH
AccessioniPrimary (citable) accession number: Q5ZVR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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