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Q5ZVR9

- LPXB1_LEGPH

UniProt

Q5ZVR9 - LPXB1_LEGPH

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Protein

Lipid-A-disaccharide synthase 1

Gene

lpxB1

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-1370-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase 1UniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxB1UniRule annotation
Ordered Locus Names:lpg1371
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000609: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Lipid-A-disaccharide synthase 1PRO_0000255194Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272624.lpg1371.

Structurei

3D structure databases

ProteinModelPortaliQ5ZVR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiTIYENAG.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZVR9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPNASRVVIV AGEESGDHHA AELVKQLKAV YPDLEISGIG GKHLRAAGVH
60 70 80 90 100
LISDLTRYAV TGLTEIIPFL KIFRKAFQDI KQHLSTQKPD LLILVDYPAF
110 120 130 140 150
NLRLAKYAKK KLGIKIIYYI SPQIWAWKGK RIHLIKDCID KMAVIFPFEK
160 170 180 190 200
TIYENAGVPV SFVGHPLVKK IAAAKDKHSG RTSLGLPLNE PIIALLPGSR
210 220 230 240 250
HSEIERHIPI LVNTAKLLTL DNPKLRFVVP IAGTINPDKV KAYFSNQNLT
260 270 280 290 300
VTFIQGQAIE CMSAADFVIV ASGTASLECA LLEKPMCIIY KSSFLTYVAA
310 320 330 340 350
MYFIKVKFLG LCNLLANKMM VPEFLQYDCN AIELSRYISN FHNDPNQAKS
360 370 380
MINQLAKLKE SLSSSQADCS LFDLVVAELP EKNA
Length:384
Mass (Da):42,634
Last modified:November 23, 2004 - v1
Checksum:iBFC508AFCACD5372
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU27453.1.
RefSeqiYP_095400.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU27453; AAU27453; lpg1371.
GeneIDi19832936.
KEGGilpn:lpg1371.
PATRICi22329836. VBILegPne29832_1441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU27453.1 .
RefSeqi YP_095400.1. NC_002942.5.

3D structure databases

ProteinModelPortali Q5ZVR9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272624.lpg1371.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU27453 ; AAU27453 ; lpg1371 .
GeneIDi 19832936.
KEGGi lpn:lpg1371.
PATRICi 22329836. VBILegPne29832_1441.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi TIYENAG.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci LPNE272624:GHDI-1370-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

Entry informationi

Entry nameiLPXB1_LEGPH
AccessioniPrimary (citable) accession number: Q5ZVR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3