ID   Q5ZVF0_LEGPH            Unreviewed;       441 AA.
AC   Q5ZVF0;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=Adenylate cyclase PLUS two component hybrid sensor and regulator {ECO:0000313|EMBL:AAU27572.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:AAU27572.1};
GN   Name=cyaA {ECO:0000313|EMBL:AAU27572.1};
GN   OrderedLocusNames=lpg1490 {ECO:0000313|EMBL:AAU27572.1};
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS   33152 / DSM 7513).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU27572.1, ECO:0000313|Proteomes:UP000000609};
RN   [1] {ECO:0000313|EMBL:AAU27572.1, ECO:0000313|Proteomes:UP000000609}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC   {ECO:0000313|Proteomes:UP000000609};
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA   Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA   Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA   Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA   Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA   Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA   Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL   Science 305:1966-1968(2004).
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DR   EMBL; AE017354; AAU27572.1; -; Genomic_DNA.
DR   RefSeq; WP_010947219.1; NC_002942.5.
DR   RefSeq; YP_095519.1; NC_002942.5.
DR   AlphaFoldDB; Q5ZVF0; -.
DR   STRING; 272624.lpg1490; -.
DR   PaxDb; 272624-lpg1490; -.
DR   GeneID; 66490622; -.
DR   KEGG; lpn:lpg1490; -.
DR   PATRIC; fig|272624.6.peg.1563; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG2203; Bacteria.
DR   HOGENOM; CLU_000445_11_32_6; -.
DR   OrthoDB; 9812358at2; -.
DR   Proteomes; UP000000609; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00065; GAF; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:AAU27572.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000609}.
FT   DOMAIN          256..388
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   441 AA;  49399 MW;  A2934DBCD2666951 CRC64;
     MSVLYYNLNN HYASHFVYSP EKRANHDNNP EKIMKKPLDT TEQNRIAALY ELKILDTPPD
     ERFDRIIRLT SGYLSVPIAF ISFIDSEHQW FKSSCGIGLN KISRNDSFCH YTIQQNKPMI
     ISDTLLDERF CNNPYVTSEP NIRFYAGFPL STVDGFNVGT LCAIDKKPRN LDETEIQILK
     DLATLAEDQL NLLDISLLEK SVREKNISLI KAKKELEMRN NFIRKVFGSF MSDEIVAALL
     ESKSELKLGG EERKITILFS DLRNFTTLSE HFPAEKIVAA LNNYYGKMVD VIEKYNGTVD
     SFIGDAIMVV FGAPHSGGDD AYRAIACALE MQVIMQEVNA MNRNSSLPEL AMGIGINTGY
     AIVGNIGSQK RMQYSAIGSP VNLASRIQDL TLGGQILISE ATYQEVNHSL ELNGHLRVKV
     KGVAAPITIY DVIGLNKKSD S
//