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Q5ZUT5 (ASTD_LEGPH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:lpg1707
OrganismLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]
Taxonomic identifier272624 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_0000262407

Regions

Nucleotide binding229 – 2346NAD By similarity

Sites

Active site2521 By similarity
Active site2861 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZUT5 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: C1704C21B77D38E6

FASTA49654,696
        10         20         30         40         50         60 
MMSKLQIIQS KGQYINGEWI KGNGLILEST NPASGTLLWQ GNNATDEEIA NACYVAHRAL 

        70         80         90        100        110        120 
KSWANTSFEE RARYTKAFVE QVEKNREQLA RLISLETGKP LWESQTEVSS VIGKVNLSIQ 

       130        140        150        160        170        180 
AYQERTWPKQ TETAEANACL RFKPHGIVVV LGAFNFPAHL SNGHIVPALL AGNTVLYKPS 

       190        200        210        220        230        240 
EHTPAVAELI IQCWHDSGLP PGVINCLQGN ANCGNTLLSQ DIQGVYFTGS YATGLRIHQQ 

       250        260        270        280        290        300 
FCNRPEVILA LEMGGNNPLV IDEVKDIDAA VYHTILSTMI TAGQRCTCAR RIIIPDSQTG 

       310        320        330        340        350        360 
DLFLERFAKA CKLMRIGSFD SQPEPFIGPV ISHVQALKHL HAQKQLIEMG GEIILPMSLL 

       370        380        390        400        410        420 
LEYTGLVSPG IIDMTRAKNP PDEEIFAPFA QIYRYNHFDE AIQLANQTRY GLSAGLLSDN 

       430        440        450        460        470        480 
KDHYQQFYQN IRAGLINWNR PTTGAASSLP FGGVGCSGNH RPSAYFAADY CAYPVASMEQ 

       490 
PLLTTPVQRL PGLVLE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017354 Genomic DNA. Translation: AAU27787.1.
RefSeqYP_095734.1. NC_002942.5.

3D structure databases

ProteinModelPortalQ5ZUT5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5ZUT5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3077778.
GenomeReviewsGene locus lpg1707 in contig AE017354_GR.
KEGGlpn:lpg1707.
NMPDRfig|272624.3.peg.537.
PATRIC22330534. VBILegPne29832_1788.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAKAYHART.
ProtClustDBPRK09457.

Enzyme and pathway databases

BioCycLPNE272624:LPG1707-MONOMER.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. False negative.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_LEGPH
AccessionPrimary (citable) accession number: Q5ZUT5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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