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Q5ZUA2

- Q5ZUA2_LEGPH

UniProt

Q5ZUA2 - Q5ZUA2_LEGPH

Protein
Submitted name:

Ectonucleoside triphosphate diphosphohydrolase I

Gene

lpg1905

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei80 – 801AMPImported
    Binding sitei118 – 1181ATPanalogImported
    Metal bindingi140 – 1401Magnesium; via carbonyl oxygenImported
    Metal bindingi143 – 1431Magnesium; via carbonyl oxygenImported
    Metal bindingi146 – 1461Magnesium; via carbonyl oxygenImported
    Binding sitei159 – 1591ATPanalogImported
    Binding sitei189 – 1891AMP; via amide nitrogenImported
    Binding sitei231 – 2311AMP
    Binding sitei302 – 3021AMP
    Binding sitei346 – 3461AMP
    Binding sitei346 – 3461ATPanalogImported
    Binding sitei350 – 3501AMPImported
    Binding sitei350 – 3501ATPanalogImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi52 – 565AMP
    Nucleotide bindingi52 – 565ATPanalogImported
    Nucleotide bindingi189 – 1913ATPanalogImported
    Nucleotide bindingi231 – 2322ATPanalogImported
    Nucleotide bindingi299 – 3024ATPanalogImported

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. nucleotide binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    HydrolaseImported

    Keywords - Ligandi

    MagnesiumImported, Metal-bindingImported, Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciLPNE272624:GHDI-1904-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ectonucleoside triphosphate diphosphohydrolase IImported
    Gene namesi
    Ordered Locus Names:lpg1905Imported
    OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)Imported
    Taxonomic identifieri272624 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000000609: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi272624.lpg1905.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3AAPX-ray1.60A41-393[»]
    3AAQX-ray2.00A41-393[»]
    3AARX-ray1.65A41-393[»]
    4BR4X-ray1.45A37-393[»]
    4BR7X-ray1.80A37-393[»]
    4BR9X-ray1.40A/B35-393[»]
    4BRAX-ray1.60A/B35-393[»]
    4BRCX-ray1.30A/B35-393[»]
    4BRDX-ray1.50A/B35-393[»]
    4BREX-ray1.60A/B35-393[»]
    4BRFX-ray1.60A/B35-393[»]
    4BRGX-ray1.45A/B35-393[»]
    4BRHX-ray1.69A/B35-393[»]
    4BRIX-ray1.75A/B35-393[»]
    4BRKX-ray1.50A/B35-393[»]
    4BRLX-ray1.60A/B35-393[»]
    4BRMX-ray2.02A/B35-393[»]
    4BRNX-ray1.69A/B35-393[»]
    4BROX-ray1.99A/B35-393[»]
    4BRPX-ray2.50A/B/C/D35-393[»]
    4BRQX-ray1.45A/B35-393[»]
    4BVOX-ray1.70A37-393[»]
    4BVPX-ray1.49A/B35-393[»]
    ProteinModelPortaliQ5ZUA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5ZUA2.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG5371.
    HOGENOMiHOG000278356.
    OMAiFANDYPL.
    OrthoDBiEOG63Z74J.

    Family and domain databases

    InterProiIPR000407. GDA1_CD39_NTPase.
    [Graphical view]
    PANTHERiPTHR11782. PTHR11782. 1 hit.
    PfamiPF01150. GDA1_CD39. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ZUA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYHSKTSILA LYQLMFRVLI FLSCLVILTP NTIADTNPCE KHSCIAVIDA    50
    GSTGSRLHIY SYDTDDTNTP IHIEEIWNKK IKPGFASIQP NSVTIDAYLT 100
    MLLADAPIHN IPVYFYATAG MRLLPQSQQK KYYDELEYWF RQQSQWQLAE 150
    AKTITGNDEA LFDWLAVNYK LDTLKSVQNK SVGVMDMGGA SVQIVFPMPK 200
    NAEISKHNQV ELNIYGQNIN LYVHSFLGLG QTEMSHQFLN SPSCFANDYP 250
    LPDGESGQGN APSCKEEVTS LMNSVHKVNQ QIQPLLALNP VNEWYSIGGI 300
    SNLASSQLFH FENSELTNQS LLQQGDNQIC HQQWDILNGQ YPDDEYLYQY 350
    CLLSSYYYAL MVDGYGINPN QTIHYIPPEQ NLDWTIGVVL HRA 393
    Length:393
    Mass (Da):44,531
    Last modified:November 23, 2004 - v1
    Checksum:i71635FBA5EA6E876
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017354 Genomic DNA. Translation: AAU27975.1.
    RefSeqiYP_095922.1. NC_002942.5.

    Genome annotation databases

    EnsemblBacteriaiAAU27975; AAU27975; lpg1905.
    GeneIDi3078951.
    KEGGilpn:lpg1905.
    PATRICi22330956. VBILegPne29832_1990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017354 Genomic DNA. Translation: AAU27975.1 .
    RefSeqi YP_095922.1. NC_002942.5.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3AAP X-ray 1.60 A 41-393 [» ]
    3AAQ X-ray 2.00 A 41-393 [» ]
    3AAR X-ray 1.65 A 41-393 [» ]
    4BR4 X-ray 1.45 A 37-393 [» ]
    4BR7 X-ray 1.80 A 37-393 [» ]
    4BR9 X-ray 1.40 A/B 35-393 [» ]
    4BRA X-ray 1.60 A/B 35-393 [» ]
    4BRC X-ray 1.30 A/B 35-393 [» ]
    4BRD X-ray 1.50 A/B 35-393 [» ]
    4BRE X-ray 1.60 A/B 35-393 [» ]
    4BRF X-ray 1.60 A/B 35-393 [» ]
    4BRG X-ray 1.45 A/B 35-393 [» ]
    4BRH X-ray 1.69 A/B 35-393 [» ]
    4BRI X-ray 1.75 A/B 35-393 [» ]
    4BRK X-ray 1.50 A/B 35-393 [» ]
    4BRL X-ray 1.60 A/B 35-393 [» ]
    4BRM X-ray 2.02 A/B 35-393 [» ]
    4BRN X-ray 1.69 A/B 35-393 [» ]
    4BRO X-ray 1.99 A/B 35-393 [» ]
    4BRP X-ray 2.50 A/B/C/D 35-393 [» ]
    4BRQ X-ray 1.45 A/B 35-393 [» ]
    4BVO X-ray 1.70 A 37-393 [» ]
    4BVP X-ray 1.49 A/B 35-393 [» ]
    ProteinModelPortali Q5ZUA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272624.lpg1905.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU27975 ; AAU27975 ; lpg1905 .
    GeneIDi 3078951.
    KEGGi lpn:lpg1905.
    PATRICi 22330956. VBILegPne29832_1990.

    Phylogenomic databases

    eggNOGi COG5371.
    HOGENOMi HOG000278356.
    OMAi FANDYPL.
    OrthoDBi EOG63Z74J.

    Enzyme and pathway databases

    BioCyci LPNE272624:GHDI-1904-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5ZUA2.

    Family and domain databases

    InterProi IPR000407. GDA1_CD39_NTPase.
    [Graphical view ]
    PANTHERi PTHR11782. PTHR11782. 1 hit.
    Pfami PF01150. GDA1_CD39. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Philadelphia 1 / ATCC 33152 / DSM 7513Imported.
    2. "Crystal structure of a Legionella pneumophila ecto -triphosphate diphosphohydrolase, a structural and functional homolog of the eukaryotic NTPDases."
      Vivian J.P., Riedmaier P., Ge H., Le Nours J., Sansom F.M., Wilce M.C., Byres E., Dias M., Schmidberger J.W., Cowan P.J., d'Apice A.J., Hartland E.L., Rossjohn J., Beddoe T.
      Structure 18:228-238(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 41-393 IN COMPLEX WITH ATPANALOG.
    3. "Crystallographic snapshots along the reaction pathway of nucleoside triphosphate diphosphohydrolases."
      Zebisch M., Krauss M., Schafer P., Lauble P., Strater N.
      Structure 21:1460-1475(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 35-393 IN COMPLEX WITH AMP; ATPANALOG AND MAGNESIUM.
    4. "Structures of Legionella pneumophila NTPDase1 in complex with polyoxometallates."
      Zebisch M., Krauss M., Schafer P., Strater N.
      Acta Crystallogr. D 70:1147-1154(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.49 ANGSTROMS) OF 35-393.

    Entry informationi

    Entry nameiQ5ZUA2_LEGPH
    AccessioniPrimary (citable) accession number: Q5ZUA2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 23, 2004
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3