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Q5ZUA2

- Q5ZUA2_LEGPH

UniProt

Q5ZUA2 - Q5ZUA2_LEGPH

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Protein
Submitted name:

Ectonucleoside triphosphate diphosphohydrolase I

Gene

lpg1905

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801AMPImported
Binding sitei118 – 1181ATPanalogImported
Metal bindingi140 – 1401Magnesium; via carbonyl oxygenImported
Metal bindingi143 – 1431Magnesium; via carbonyl oxygenImported
Metal bindingi146 – 1461Magnesium; via carbonyl oxygenImported
Binding sitei159 – 1591ATPanalogImported
Binding sitei189 – 1891AMP; via amide nitrogenImported
Binding sitei231 – 2311AMP
Binding sitei302 – 3021AMP
Binding sitei346 – 3461AMP
Binding sitei346 – 3461ATPanalogImported
Binding sitei350 – 3501AMPImported
Binding sitei350 – 3501ATPanalogImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi52 – 565AMP
Nucleotide bindingi52 – 565ATPanalogImported
Nucleotide bindingi189 – 1913ATPanalogImported
Nucleotide bindingi231 – 2322ATPanalogImported
Nucleotide bindingi299 – 3024ATPanalogImported

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Keywords - Ligandi

MagnesiumImported, Metal-bindingImported, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-1904-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Ectonucleoside triphosphate diphosphohydrolase IImported
Gene namesi
Ordered Locus Names:lpg1905Imported
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)Imported
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000609: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272624.lpg1905.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AAPX-ray1.60A41-393[»]
3AAQX-ray2.00A41-393[»]
3AARX-ray1.65A41-393[»]
4BR4X-ray1.45A37-393[»]
4BR7X-ray1.80A37-393[»]
4BR9X-ray1.40A/B35-393[»]
4BRAX-ray1.60A/B35-393[»]
4BRCX-ray1.30A/B35-393[»]
4BRDX-ray1.50A/B35-393[»]
4BREX-ray1.60A/B35-393[»]
4BRFX-ray1.60A/B35-393[»]
4BRGX-ray1.45A/B35-393[»]
4BRHX-ray1.69A/B35-393[»]
4BRIX-ray1.75A/B35-393[»]
4BRKX-ray1.50A/B35-393[»]
4BRLX-ray1.60A/B35-393[»]
4BRMX-ray2.02A/B35-393[»]
4BRNX-ray1.69A/B35-393[»]
4BROX-ray1.99A/B35-393[»]
4BRPX-ray2.50A/B/C/D35-393[»]
4BRQX-ray1.45A/B35-393[»]
4BVOX-ray1.70A37-393[»]
4BVPX-ray1.49A/B35-393[»]
ProteinModelPortaliQ5ZUA2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5ZUA2.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG5371.
HOGENOMiHOG000278356.
OMAiFANDYPL.
OrthoDBiEOG63Z74J.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZUA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYHSKTSILA LYQLMFRVLI FLSCLVILTP NTIADTNPCE KHSCIAVIDA
60 70 80 90 100
GSTGSRLHIY SYDTDDTNTP IHIEEIWNKK IKPGFASIQP NSVTIDAYLT
110 120 130 140 150
MLLADAPIHN IPVYFYATAG MRLLPQSQQK KYYDELEYWF RQQSQWQLAE
160 170 180 190 200
AKTITGNDEA LFDWLAVNYK LDTLKSVQNK SVGVMDMGGA SVQIVFPMPK
210 220 230 240 250
NAEISKHNQV ELNIYGQNIN LYVHSFLGLG QTEMSHQFLN SPSCFANDYP
260 270 280 290 300
LPDGESGQGN APSCKEEVTS LMNSVHKVNQ QIQPLLALNP VNEWYSIGGI
310 320 330 340 350
SNLASSQLFH FENSELTNQS LLQQGDNQIC HQQWDILNGQ YPDDEYLYQY
360 370 380 390
CLLSSYYYAL MVDGYGINPN QTIHYIPPEQ NLDWTIGVVL HRA
Length:393
Mass (Da):44,531
Last modified:November 23, 2004 - v1
Checksum:i71635FBA5EA6E876
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017354 Genomic DNA. Translation: AAU27975.1.
RefSeqiYP_095922.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU27975; AAU27975; lpg1905.
GeneIDi19833471.
KEGGilpn:lpg1905.
PATRICi22330956. VBILegPne29832_1990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017354 Genomic DNA. Translation: AAU27975.1 .
RefSeqi YP_095922.1. NC_002942.5.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3AAP X-ray 1.60 A 41-393 [» ]
3AAQ X-ray 2.00 A 41-393 [» ]
3AAR X-ray 1.65 A 41-393 [» ]
4BR4 X-ray 1.45 A 37-393 [» ]
4BR7 X-ray 1.80 A 37-393 [» ]
4BR9 X-ray 1.40 A/B 35-393 [» ]
4BRA X-ray 1.60 A/B 35-393 [» ]
4BRC X-ray 1.30 A/B 35-393 [» ]
4BRD X-ray 1.50 A/B 35-393 [» ]
4BRE X-ray 1.60 A/B 35-393 [» ]
4BRF X-ray 1.60 A/B 35-393 [» ]
4BRG X-ray 1.45 A/B 35-393 [» ]
4BRH X-ray 1.69 A/B 35-393 [» ]
4BRI X-ray 1.75 A/B 35-393 [» ]
4BRK X-ray 1.50 A/B 35-393 [» ]
4BRL X-ray 1.60 A/B 35-393 [» ]
4BRM X-ray 2.02 A/B 35-393 [» ]
4BRN X-ray 1.69 A/B 35-393 [» ]
4BRO X-ray 1.99 A/B 35-393 [» ]
4BRP X-ray 2.50 A/B/C/D 35-393 [» ]
4BRQ X-ray 1.45 A/B 35-393 [» ]
4BVO X-ray 1.70 A 37-393 [» ]
4BVP X-ray 1.49 A/B 35-393 [» ]
ProteinModelPortali Q5ZUA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272624.lpg1905.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU27975 ; AAU27975 ; lpg1905 .
GeneIDi 19833471.
KEGGi lpn:lpg1905.
PATRICi 22330956. VBILegPne29832_1990.

Phylogenomic databases

eggNOGi COG5371.
HOGENOMi HOG000278356.
OMAi FANDYPL.
OrthoDBi EOG63Z74J.

Enzyme and pathway databases

BioCyci LPNE272624:GHDI-1904-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5ZUA2.

Family and domain databases

InterProi IPR000407. GDA1_CD39_NTPase.
[Graphical view ]
PANTHERi PTHR11782. PTHR11782. 1 hit.
Pfami PF01150. GDA1_CD39. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Philadelphia 1 / ATCC 33152 / DSM 7513Imported.
  2. "Crystal structure of a Legionella pneumophila ecto -triphosphate diphosphohydrolase, a structural and functional homolog of the eukaryotic NTPDases."
    Vivian J.P., Riedmaier P., Ge H., Le Nours J., Sansom F.M., Wilce M.C., Byres E., Dias M., Schmidberger J.W., Cowan P.J., d'Apice A.J., Hartland E.L., Rossjohn J., Beddoe T.
    Structure 18:228-238(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 41-393 IN COMPLEX WITH ATPANALOG.
  3. "Crystallographic snapshots along the reaction pathway of nucleoside triphosphate diphosphohydrolases."
    Zebisch M., Krauss M., Schafer P., Lauble P., Strater N.
    Structure 21:1460-1475(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 35-393 IN COMPLEX WITH AMP; ATPANALOG AND MAGNESIUM.
  4. "Structures of Legionella pneumophila NTPDase1 in complex with polyoxometallates."
    Zebisch M., Krauss M., Schafer P., Strater N.
    Acta Crystallogr. D 70:1147-1154(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.49 ANGSTROMS) OF 35-393.

Entry informationi

Entry nameiQ5ZUA2_LEGPH
AccessioniPrimary (citable) accession number: Q5ZUA2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3