Q5ZTI6 (SGPL_LEGPH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable sphingosine-1-phosphate lyase
Short name=S1PL
Short name=SP-lyase
Short name=SPL
EC=4.1.2.27

Alternative name(s):
Sphingosine-1-phosphate aldolase

Gene names

Ordered Locus Names:

lpg2176

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	601 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine By similarity. Possibly implicated in influencing the macrophage autophagy pathway. Ref.2
Catalytic activity	Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
Sequence caution	The sequence AAU28241.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carboxylic acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	carboxy-lyase activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro sphinganine-1-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 601	601	Probable sphingosine-1-phosphate lyase		PRO_0000248941
Amino acid modifications
	Modified residue	360	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZTI6 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: D19C9FF7C61A8A31	FASTA	601	66,549
	10 20 30 40 50 60 MFGFVSDLLT AAVSSLDELL QDTPAHQIIL GTAALYFLYN QYHNPSISRW YRSRNNASMK 70 80 90 100 110 120 QRIIDSAYAL AKNLPGVNQI IEKELNKELS STREKLRIQR SGMTLREEIP EEGLSPQDIL 130 140 150 160 170 180 SAFDVDVEKC HFDFLSVTND SPEREFLVER GDGKDSGALY AIHPKELTEL LKEVYGATAL 190 200 210 220 230 240 TNPLHDKWPR INAMQAEVIR WCQNLFHGSK ECYGLLTHGG TTSIIEAMAA YVIRARAKGI 250 260 270 280 290 300 DYPEIVVPET AHAAFKKAAE LTGAILITVP VDKKTGAVNP KVMSSYITRN TAVIVGSAPS 310 320 330 340 350 360 FMNGIHDPVS ELGQLAKKKN VPFHVDACLG GFLTAFLDTS SEPMDFRVPG VTSISADLHK 370 380 390 400 410 420 YGCCPKGTSV CLFSEDSPAL SVYAALNWSG GLYATPGILD GSTSGARVAE VYATLSYYGK 430 440 450 460 470 480 NKYQEIAKSI ITLRNAIQKE LTTLLEEGNG LTSEDIYVYG NPQWSILGFR SNTCNAHFIA 490 500 510 520 530 540 DELEKRGWKL NLLQNPDGFH LCLTHVHTLV KGFETQFIKD LREAVIDVKN YPPGKKPSGN 550 560 570 580 590 600 VKVYGAVGMM PIELQREICK QYQKARLNYT SASPGSLRIF TNVPVEEDEG LRNRKTEKYK V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J. Science 305:1966-1968(2004) [PubMed: 15448271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.
[2]	"Adaptation of Legionella pneumophila to the host environment: role of protein secretion, effectors and eukaryotic-like proteins." Brueggemann H., Cazalet C., Buchrieser C. Curr. Opin. Microbiol. 9:86-94(2006) [PubMed: 16406773] [Abstract] Cited for: POSSIBLE FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017354 Genomic DNA. Translation: AAU28241.1. Different initiation.
RefSeq	YP_096188.1. NC_002942.5.
3D structure databases
ProteinModelPortal	Q5ZTI6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZTI6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3078567.
GenomeReviews	Gene locus lpg2176 in contig AE017354_GR.
KEGG	lpn:lpg2176.
NMPDR	fig|272624.3.peg.1018.
PATRIC	22331557. VBILegPne29832_2285.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0076.
HOGENOM	HBG657947.
OMA	MESEIVA.
ProtClustDB	CLSK833230.
Enzyme and pathway databases
BioCyc	LPNE272624:LPG2176-MONOMER.
Family and domain databases
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KO	K01634.
PANTHER	PTHR11999. Pyridoxal_deC. 1 hit.
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SGPL_LEGPH

Accession

Primary (citable) accession number: Q5ZTI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program