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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei95Transition state stabilizerUniRule annotation1
Active sitei99Proton acceptorUniRule annotation1
Metal bindingi264Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2643. LpnCP02_Philadelphia-1.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:lpg2389
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000000609 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548221 – 721Catalase-peroxidase 1Add BLAST721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki98 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-98)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PaxDbiQ5ZSX7.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272624.lpg2389.

Structurei

3D structure databases

ProteinModelPortaliQ5ZSX7.
SMRiQ5ZSX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiView protein in InterPro
IPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
PANTHERiPTHR30555. PTHR30555. 1 hit.
PfamiView protein in Pfam
PF00141. peroxidase. 2 hits.
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiView protein in PROSITE
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZSX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGKVGSTTT GCPVIHGGMT STGTSNTAWW PNALNLDILH QHDTKTNPME
60 70 80 90 100
KDFNYREEVK KLDFEALKKD LHALMTDSQA WWPADWGHYG GLMIRMSWHA
110 120 130 140 150
AGSYRVADGR GGAGTGNQRF APLNSWPDNV NLDKARRLLW PIKKKYGNKI
160 170 180 190 200
SWADLIVLAG TIAYESMGLK TFGFGFGRED IWHPEKDVYW GSEQEWLGAK
210 220 230 240 250
RYDGKSRESL ENPLAAVQMG LIYVNPEGVN GQPDPLRTAQ DVRVTFGRMA
260 270 280 290 300
MNDEETVALT AGGHTVGKCH GNGNAKLLGP NPEAANVEDQ GLGWINKTTR
310 320 330 340 350
GIGRNTVSSG IEGAWTTHPT QWDNGYFYLL LNYDWELKKS PAGAWQWEPI
360 370 380 390 400
HIKEEDKPVD VEDPAIRHNP IMTDADMAMK MDPVYRKIAE RFYQDPDYFA
410 420 430 440 450
EVFARAWFKL THRDMGPKTR YIGPDVPKED LIWQDPVPAG NRAYDIAAAK
460 470 480 490 500
AKIAASNLTI GEMVSTAWDS ARTFRGSDKR GGANGARIRL KPQKDWEGNE
510 520 530 540 550
PQRLTKVLQI LEDIATDTGA SVADVIILAG NVGIEKAAKA AGFDIIVPFA
560 570 580 590 600
PGRGDATDDM TDAESFDVLE PLHDGYRNWL KKTYDVRPEE LMLDRTQLMG
610 620 630 640 650
LTAHEMTVLV GGLRVLGTNH NNTQYGVFTD RVGALTNDFF VNLTDMANVW
660 670 680 690 700
IPSKDNLYEI RDRKAGNIKW TATRVDLVFG SNSILRSYAE VYAQDDNKGK
710 720
FIQDFVAAWT KVMNADRFDL A
Length:721
Mass (Da):80,500
Last modified:November 25, 2008 - v2
Checksum:iD96347BDAD0B719C
GO

Sequence cautioni

The sequence AAU28450 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU28450.1. Different initiation.
RefSeqiYP_096397.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU28450; AAU28450; lpg2389.
GeneIDi19833954.
KEGGilpn:lpg2389.
PATRICifig|272624.6.peg.2525.

Similar proteinsi

Entry informationi

Entry nameiKATG1_LEGPH
AccessioniPrimary (citable) accession number: Q5ZSX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: August 30, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families