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Q5ZSN0

- DUT_LEGPH

UniProt

Q5ZSN0 - DUT_LEGPH

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841SubstrateUniRule annotation
    Binding sitei98 – 981Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciLPNE272624:GHDI-2486-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:lpg2487
    OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
    Taxonomic identifieri272624 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000000609: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 152152Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182874Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272624.lpg2487.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZSN0.
    SMRiQ5ZSN0. Positions 1-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni71 – 733Substrate bindingUniRule annotation
    Regioni88 – 903Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dUTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0756.
    HOGENOMiHOG000028968.
    KOiK01520.
    OrthoDBiEOG689HXK.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00116. dUTPase_bact.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5ZSN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHQVIQLKIL DSRIGDTIPL PAYATDGSAG LDLRVCISEP MQVAPQQTVL    50
    LPTGIAIYIA DPKLAAVILP RSGLGHKNGI VLGNLVGLID SDYQGELKIS 100
    CWNRSQEHFT VNPGDRIAQL VFIPVVQASF EVVNEFTESS RGEGGFGSSG 150
    RY 152
    Length:152
    Mass (Da):16,347
    Last modified:March 15, 2005 - v2
    Checksum:i37E05FB3A74BAE5D
    GO

    Sequence cautioni

    The sequence AAU28547.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017354 Genomic DNA. Translation: AAU28547.1. Different initiation.
    RefSeqiYP_007567117.1. NC_020521.1.
    YP_096494.1. NC_002942.5.

    Genome annotation databases

    EnsemblBacteriaiAAU28547; AAU28547; lpg2487.
    GeneIDi14799266.
    3080618.
    KEGGilpn:lpg2487.
    lpu:LPE509_00574.
    PATRICi22332267. VBILegPne29832_2636.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017354 Genomic DNA. Translation: AAU28547.1 . Different initiation.
    RefSeqi YP_007567117.1. NC_020521.1.
    YP_096494.1. NC_002942.5.

    3D structure databases

    ProteinModelPortali Q5ZSN0.
    SMRi Q5ZSN0. Positions 1-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272624.lpg2487.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU28547 ; AAU28547 ; lpg2487 .
    GeneIDi 14799266.
    3080618.
    KEGGi lpn:lpg2487.
    lpu:LPE509_00574.
    PATRICi 22332267. VBILegPne29832_2636.

    Phylogenomic databases

    eggNOGi COG0756.
    HOGENOMi HOG000028968.
    KOi K01520.
    OrthoDBi EOG689HXK.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci LPNE272624:GHDI-2486-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00116. dUTPase_bact.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

    Entry informationi

    Entry nameiDUT_LEGPH
    AccessioniPrimary (citable) accession number: Q5ZSN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3