ID Q5ZSM7_LEGPH Unreviewed; 1294 AA. AC Q5ZSM7; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 27-MAR-2024, entry version 98. DE SubName: Full=LepB {ECO:0000313|EMBL:AAU28550.1}; GN Name=lepB {ECO:0000313|EMBL:AAU28550.1}; GN OrderedLocusNames=lpg2490 {ECO:0000313|EMBL:AAU28550.1}; OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC OS 33152 / DSM 7513). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; OC Legionellaceae; Legionella. OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU28550.1, ECO:0000313|Proteomes:UP000000609}; RN [1] {ECO:0000313|EMBL:AAU28550.1, ECO:0000313|Proteomes:UP000000609} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513 RC {ECO:0000313|Proteomes:UP000000609}; RX PubMed=15448271; DOI=10.1126/science.1099776; RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A., RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., RA Russo J.J.; RT "The genomic sequence of the accidental pathogen Legionella pneumophila."; RL Science 305:1966-1968(2004). RN [2] {ECO:0007829|PDB:4I1M, ECO:0007829|PDB:4I1O} RP X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 317-618 IN COMPLEX WITH GDP. RX PubMed=23288104; DOI=10.1038/embor.2012.211; RA Mihai Gazdag E., Streller A., Haneburger I., Hilbi H., Vetter I.R., RA Goody R.S., Itzen A.; RT "Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB."; RL EMBO Rep. 14:199-205(2013). RN [3] {ECO:0007829|PDB:4IRU} RP X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 326-623 IN COMPLEX WITH GDP. RX PubMed=23821544; DOI=10.1074/jbc.M113.470625; RA Mishra A.K., Del Campo C.M., Collins R.E., Roy C.R., Lambright D.G.; RT "The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 RT deactivation by a non-canonical hydrolytic mechanism."; RL J. Biol. Chem. 288:24000-24011(2013). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017354; AAU28550.1; -; Genomic_DNA. DR RefSeq; WP_010948192.1; NC_002942.5. DR RefSeq; YP_096497.1; NC_002942.5. DR PDB; 4I1M; X-ray; 2.80 A; A/B/C=317-618. DR PDB; 4I1O; X-ray; 2.70 A; B/D/F/H=317-618. DR PDB; 4IRU; X-ray; 3.20 A; A/C/E=326-623. DR PDBsum; 4I1M; -. DR PDBsum; 4I1O; -. DR PDBsum; 4IRU; -. DR SMR; Q5ZSM7; -. DR IntAct; Q5ZSM7; 1. DR MINT; Q5ZSM7; -. DR STRING; 272624.lpg2490; -. DR PaxDb; 272624-lpg2490; -. DR KEGG; lpn:lpg2490; -. DR PATRIC; fig|272624.6.peg.2640; -. DR eggNOG; COG1196; Bacteria. DR HOGENOM; CLU_261963_0_0_6; -. DR OrthoDB; 5619798at2; -. DR SABIO-RK; Q5ZSM7; -. DR Proteomes; UP000000609; Chromosome. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR CDD; cd14436; LepB; 1. DR Gene3D; 1.20.120.1700; -; 1. DR Gene3D; 1.25.40.830; -; 1. DR InterPro; IPR040484; LepB_GAP_C. DR InterPro; IPR041585; LepB_GAP_N. DR InterPro; IPR040519; LepB_N. DR PANTHER; PTHR34491; A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED; 1. DR PANTHER; PTHR34491:SF155; CENTRIOLIN; 1. DR Pfam; PF18227; LepB_GAP_C; 1. DR Pfam; PF18172; LepB_GAP_N; 1. DR Pfam; PF18640; LepB_N; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:4I1M, ECO:0007829|PDB:4I1O}; KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000609}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1234..1256 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 125..305 FT /note="LepB N-terminal" FT /evidence="ECO:0000259|Pfam:PF18640" FT DOMAIN 331..522 FT /note="LepB GAP" FT /evidence="ECO:0000259|Pfam:PF18172" FT DOMAIN 534..612 FT /note="LepB GAP" FT /evidence="ECO:0000259|Pfam:PF18227" FT COILED 625..1179 FT /evidence="ECO:0000256|SAM:Coils" FT BINDING 444 FT /ligand="GDP" FT /ligand_id="ChEBI:CHEBI:58189" FT /evidence="ECO:0007829|PDB:4I1O" SQ SEQUENCE 1294 AA; 148752 MW; CDAAA3F035EA8B9B CRC64; MLIYQGKEIV RFKEKTGGKN KSDVDGFYKD NDGGKFFIKK PGDPRELFTE LFAGLLLKEF MKRGLIDESY FPSLICADVI QFEDKSYGLI QPLVSFDELH KVIGTSSGDG KDRNTLKETL FGPGYYAGIT KQNKYFGLSM ALMFSLLLGA HSVHSGNIVV LNGEEKEKSK QFGRIDWGDA FRYFAHPNNN DNLLYAYENR GWFNYKSLTK DYFLNYKKIN GLFPAMAEKA RQLQSKLNPE LLVKIVTSAL KNIPADLIDE KTKIQLAAYM CMDSFKEATF GTEGNCKDFA IAMATLLENR LGKIAVLKDM SPLSNPEELY QSILELKPLT LLMTSSTSFS ETINQWADIL KTTDMEKFSF DSNPINLLEL VKQFNLYVDE LAITCEANNV WAKERIDSTP NLFALYDNSG GEAIHGHAFV PYYKESIVLR RLFTVDPNTF NLSRFAAFEG PCQLYCKEHK DSAWVKIQTL LTLGNGIINT LKIIKQAQAF GIDEAVTENL KALKEQFIAF QLAEADIKES LKAPSFAEPL PNKESEFFYP IDEKALAKMN GYQLATICLE ELNSPKPSPL IERILSNKKF WKRINSAFES GVFKGRTDDP AGKIAKIREW HQLLQISGKK TAGQIDELQK IVISLQSKIK RQTIEFEELE ATLIQIKEKY QLLEKMAEQS EHEKSSAQSI IRSLNLELSQ LKLQLQEQEK LQFQLKELKE KIHEQTTLSK RLGEELQTQK KTNTHQEETI QRITKEKSLA DSSLESLRKE LHELAKKERS LHKTLEEKQL QVQQLEEQLA EKEKENLALK KADKQSQHEK SLDKSAIESL TSELNQLKLE LQKQETLQLQ LKSLRKQIQE QTLVVEGLKE ELQKQKKSNT HQEETIERIT KEKSLADSAL ESLRKEMYEL TRKNEENQLK LTKQVHSLSE QLEEKQLQIR EFEKQLQEKE KRVEQSEKGK ASAKRTVASL REQVSNLKLQ LQQLGEVIQE KEKGSSLISQ QSKQIIALQE IIEDQKRQLE ELKIKIQELV SANQELGKQN QSLSKENLHN KNTVEDLKKK LNELNVQLEQ LHQSSNEKEQ TIRKLREELI KKDSSLKQNE EMQLAQKHLQ EEIDRLQKEI KQQQLNTNQL ESIIAQSKEA EKRYQQALQQ KKGIYFARME RVSPIYLQIQ QIEQKAKELE ERRETEASTA AKTLATKLRL EIKNYLDNNE SDEKSALNSF KINAKRHIEN SKETLNQHRE EWKYLLANVT LGVFLLGIGY LAAILINKAT TGNYTFFSQT NSGKKLDALE KAISSTHSET LVYG //