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Q5ZSM7

- Q5ZSM7_LEGPH

UniProt

Q5ZSM7 - Q5ZSM7_LEGPH

Protein
Submitted name:

LepB

Gene

lepB

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei368 – 3681Acetate 1; via amide nitrogenImported

    Enzyme and pathway databases

    BioCyciLPNE272624:GHDI-2489-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    LepBImported
    Gene namesi
    Name:lepBImported
    Ordered Locus Names:lpg2490Imported
    OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)Imported
    Taxonomic identifieri272624 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000000609: Chromosome

    Interactioni

    Protein-protein interaction databases

    IntActiQ5ZSM7. 1 interaction.
    STRINGi272624.lpg2490.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I1MX-ray2.80A/B/C317-618[»]
    4I1OX-ray2.70B/D/F/H317-618[»]
    4IRUX-ray3.20A/C/E326-623[»]
    ProteinModelPortaliQ5ZSM7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000278672.
    KOiK15492.
    OMAiSVEDRDN.
    OrthoDBiEOG6SJJMS.

    Sequencei

    Sequence statusi: Complete.

    Q5ZSM7-1 [UniParc]FASTAAdd to Basket

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    MLIYQGKEIV RFKEKTGGKN KSDVDGFYKD NDGGKFFIKK PGDPRELFTE     50
    LFAGLLLKEF MKRGLIDESY FPSLICADVI QFEDKSYGLI QPLVSFDELH 100
    KVIGTSSGDG KDRNTLKETL FGPGYYAGIT KQNKYFGLSM ALMFSLLLGA 150
    HSVHSGNIVV LNGEEKEKSK QFGRIDWGDA FRYFAHPNNN DNLLYAYENR 200
    GWFNYKSLTK DYFLNYKKIN GLFPAMAEKA RQLQSKLNPE LLVKIVTSAL 250
    KNIPADLIDE KTKIQLAAYM CMDSFKEATF GTEGNCKDFA IAMATLLENR 300
    LGKIAVLKDM SPLSNPEELY QSILELKPLT LLMTSSTSFS ETINQWADIL 350
    KTTDMEKFSF DSNPINLLEL VKQFNLYVDE LAITCEANNV WAKERIDSTP 400
    NLFALYDNSG GEAIHGHAFV PYYKESIVLR RLFTVDPNTF NLSRFAAFEG 450
    PCQLYCKEHK DSAWVKIQTL LTLGNGIINT LKIIKQAQAF GIDEAVTENL 500
    KALKEQFIAF QLAEADIKES LKAPSFAEPL PNKESEFFYP IDEKALAKMN 550
    GYQLATICLE ELNSPKPSPL IERILSNKKF WKRINSAFES GVFKGRTDDP 600
    AGKIAKIREW HQLLQISGKK TAGQIDELQK IVISLQSKIK RQTIEFEELE 650
    ATLIQIKEKY QLLEKMAEQS EHEKSSAQSI IRSLNLELSQ LKLQLQEQEK 700
    LQFQLKELKE KIHEQTTLSK RLGEELQTQK KTNTHQEETI QRITKEKSLA 750
    DSSLESLRKE LHELAKKERS LHKTLEEKQL QVQQLEEQLA EKEKENLALK 800
    KADKQSQHEK SLDKSAIESL TSELNQLKLE LQKQETLQLQ LKSLRKQIQE 850
    QTLVVEGLKE ELQKQKKSNT HQEETIERIT KEKSLADSAL ESLRKEMYEL 900
    TRKNEENQLK LTKQVHSLSE QLEEKQLQIR EFEKQLQEKE KRVEQSEKGK 950
    ASAKRTVASL REQVSNLKLQ LQQLGEVIQE KEKGSSLISQ QSKQIIALQE 1000
    IIEDQKRQLE ELKIKIQELV SANQELGKQN QSLSKENLHN KNTVEDLKKK 1050
    LNELNVQLEQ LHQSSNEKEQ TIRKLREELI KKDSSLKQNE EMQLAQKHLQ 1100
    EEIDRLQKEI KQQQLNTNQL ESIIAQSKEA EKRYQQALQQ KKGIYFARME 1150
    RVSPIYLQIQ QIEQKAKELE ERRETEASTA AKTLATKLRL EIKNYLDNNE 1200
    SDEKSALNSF KINAKRHIEN SKETLNQHRE EWKYLLANVT LGVFLLGIGY 1250
    LAAILINKAT TGNYTFFSQT NSGKKLDALE KAISSTHSET LVYG 1294
    Length:1,294
    Mass (Da):148,752
    Last modified:November 23, 2004 - v1
    Checksum:iCDAAA3F035EA8B9B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017354 Genomic DNA. Translation: AAU28550.1.
    RefSeqiYP_007567113.1. NC_020521.1.
    YP_096497.1. NC_002942.5.

    Genome annotation databases

    EnsemblBacteriaiAAU28550; AAU28550; lpg2490.
    GeneIDi14799262.
    3080286.
    KEGGilpn:lpg2490.
    lpu:LPE509_00570.
    PATRICi22332275. VBILegPne29832_2640.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017354 Genomic DNA. Translation: AAU28550.1 .
    RefSeqi YP_007567113.1. NC_020521.1.
    YP_096497.1. NC_002942.5.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I1M X-ray 2.80 A/B/C 317-618 [» ]
    4I1O X-ray 2.70 B/D/F/H 317-618 [» ]
    4IRU X-ray 3.20 A/C/E 326-623 [» ]
    ProteinModelPortali Q5ZSM7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5ZSM7. 1 interaction.
    STRINGi 272624.lpg2490.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU28550 ; AAU28550 ; lpg2490 .
    GeneIDi 14799262.
    3080286.
    KEGGi lpn:lpg2490.
    lpu:LPE509_00570.
    PATRICi 22332275. VBILegPne29832_2640.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000278672.
    KOi K15492.
    OMAi SVEDRDN.
    OrthoDBi EOG6SJJMS.

    Enzyme and pathway databases

    BioCyci LPNE272624:GHDI-2489-MONOMER.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Philadelphia 1 / ATCC 33152 / DSM 7513Imported.
    2. "Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB."
      Mihai Gazdag E., Streller A., Haneburger I., Hilbi H., Vetter I.R., Goody R.S., Itzen A.
      EMBO Rep. 14:199-205(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 317-618.
    3. "The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism."
      Mishra A.K., Del Campo C.M., Collins R.E., Roy C.R., Lambright D.G.
      J. Biol. Chem. 288:24000-24011(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 326-623.

    Entry informationi

    Entry nameiQ5ZSM7_LEGPH
    AccessioniPrimary (citable) accession number: Q5ZSM7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 23, 2004
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3