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Q5ZSM7

- Q5ZSM7_LEGPH

UniProt

Q5ZSM7 - Q5ZSM7_LEGPH

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Protein
Submitted name:

LepB

Gene

lepB

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei368 – 3681Acetate 1; via amide nitrogenImported

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-2489-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
LepBImported
Gene namesi
Name:lepBImported
Ordered Locus Names:lpg2490Imported
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)Imported
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000609: Chromosome

Interactioni

Protein-protein interaction databases

IntActiQ5ZSM7. 1 interaction.
STRINGi272624.lpg2490.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I1MX-ray2.80A/B/C317-618[»]
4I1OX-ray2.70B/D/F/H317-618[»]
4IRUX-ray3.20A/C/E326-623[»]
ProteinModelPortaliQ5ZSM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000278672.
KOiK15492.
OMAiSVEDRDN.
OrthoDBiEOG6SJJMS.

Sequencei

Sequence statusi: Complete.

Q5ZSM7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MLIYQGKEIV RFKEKTGGKN KSDVDGFYKD NDGGKFFIKK PGDPRELFTE
60 70 80 90 100
LFAGLLLKEF MKRGLIDESY FPSLICADVI QFEDKSYGLI QPLVSFDELH
110 120 130 140 150
KVIGTSSGDG KDRNTLKETL FGPGYYAGIT KQNKYFGLSM ALMFSLLLGA
160 170 180 190 200
HSVHSGNIVV LNGEEKEKSK QFGRIDWGDA FRYFAHPNNN DNLLYAYENR
210 220 230 240 250
GWFNYKSLTK DYFLNYKKIN GLFPAMAEKA RQLQSKLNPE LLVKIVTSAL
260 270 280 290 300
KNIPADLIDE KTKIQLAAYM CMDSFKEATF GTEGNCKDFA IAMATLLENR
310 320 330 340 350
LGKIAVLKDM SPLSNPEELY QSILELKPLT LLMTSSTSFS ETINQWADIL
360 370 380 390 400
KTTDMEKFSF DSNPINLLEL VKQFNLYVDE LAITCEANNV WAKERIDSTP
410 420 430 440 450
NLFALYDNSG GEAIHGHAFV PYYKESIVLR RLFTVDPNTF NLSRFAAFEG
460 470 480 490 500
PCQLYCKEHK DSAWVKIQTL LTLGNGIINT LKIIKQAQAF GIDEAVTENL
510 520 530 540 550
KALKEQFIAF QLAEADIKES LKAPSFAEPL PNKESEFFYP IDEKALAKMN
560 570 580 590 600
GYQLATICLE ELNSPKPSPL IERILSNKKF WKRINSAFES GVFKGRTDDP
610 620 630 640 650
AGKIAKIREW HQLLQISGKK TAGQIDELQK IVISLQSKIK RQTIEFEELE
660 670 680 690 700
ATLIQIKEKY QLLEKMAEQS EHEKSSAQSI IRSLNLELSQ LKLQLQEQEK
710 720 730 740 750
LQFQLKELKE KIHEQTTLSK RLGEELQTQK KTNTHQEETI QRITKEKSLA
760 770 780 790 800
DSSLESLRKE LHELAKKERS LHKTLEEKQL QVQQLEEQLA EKEKENLALK
810 820 830 840 850
KADKQSQHEK SLDKSAIESL TSELNQLKLE LQKQETLQLQ LKSLRKQIQE
860 870 880 890 900
QTLVVEGLKE ELQKQKKSNT HQEETIERIT KEKSLADSAL ESLRKEMYEL
910 920 930 940 950
TRKNEENQLK LTKQVHSLSE QLEEKQLQIR EFEKQLQEKE KRVEQSEKGK
960 970 980 990 1000
ASAKRTVASL REQVSNLKLQ LQQLGEVIQE KEKGSSLISQ QSKQIIALQE
1010 1020 1030 1040 1050
IIEDQKRQLE ELKIKIQELV SANQELGKQN QSLSKENLHN KNTVEDLKKK
1060 1070 1080 1090 1100
LNELNVQLEQ LHQSSNEKEQ TIRKLREELI KKDSSLKQNE EMQLAQKHLQ
1110 1120 1130 1140 1150
EEIDRLQKEI KQQQLNTNQL ESIIAQSKEA EKRYQQALQQ KKGIYFARME
1160 1170 1180 1190 1200
RVSPIYLQIQ QIEQKAKELE ERRETEASTA AKTLATKLRL EIKNYLDNNE
1210 1220 1230 1240 1250
SDEKSALNSF KINAKRHIEN SKETLNQHRE EWKYLLANVT LGVFLLGIGY
1260 1270 1280 1290
LAAILINKAT TGNYTFFSQT NSGKKLDALE KAISSTHSET LVYG
Length:1,294
Mass (Da):148,752
Last modified:November 23, 2004 - v1
Checksum:iCDAAA3F035EA8B9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU28550.1.
RefSeqiYP_096497.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU28550; AAU28550; lpg2490.
GeneIDi19834055.
KEGGilpn:lpg2490.
lpu:LPE509_00570.
PATRICi22332275. VBILegPne29832_2640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU28550.1 .
RefSeqi YP_096497.1. NC_002942.5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I1M X-ray 2.80 A/B/C 317-618 [» ]
4I1O X-ray 2.70 B/D/F/H 317-618 [» ]
4IRU X-ray 3.20 A/C/E 326-623 [» ]
ProteinModelPortali Q5ZSM7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5ZSM7. 1 interaction.
STRINGi 272624.lpg2490.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU28550 ; AAU28550 ; lpg2490 .
GeneIDi 19834055.
KEGGi lpn:lpg2490.
lpu:LPE509_00570.
PATRICi 22332275. VBILegPne29832_2640.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000278672.
KOi K15492.
OMAi SVEDRDN.
OrthoDBi EOG6SJJMS.

Enzyme and pathway databases

BioCyci LPNE272624:GHDI-2489-MONOMER.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Philadelphia 1 / ATCC 33152 / DSM 7513Imported.
  2. "Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB."
    Mihai Gazdag E., Streller A., Haneburger I., Hilbi H., Vetter I.R., Goody R.S., Itzen A.
    EMBO Rep. 14:199-205(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 317-618.
  3. "The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism."
    Mishra A.K., Del Campo C.M., Collins R.E., Roy C.R., Lambright D.G.
    J. Biol. Chem. 288:24000-24011(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 326-623.

Entry informationi

Entry nameiQ5ZSM7_LEGPH
AccessioniPrimary (citable) accession number: Q5ZSM7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3