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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:lpg2617
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000000609 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalUniRule annotationAdd BLAST21
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei97 – 117HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei167 – 187HelicalUniRule annotationAdd BLAST21
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Transmembranei236 – 256HelicalUniRule annotationAdd BLAST21
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei338 – 358HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088431 – 361Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST361

Proteomic databases

PaxDbiQ5ZSA2
PRIDEiQ5ZSA2

Interactioni

Protein-protein interaction databases

STRINGi272624.lpg2617

Structurei

3D structure databases

SMRiQ5ZSA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275122
KOiK01000

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZSA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYWLTQLLQ GQYHAFRVFQ YLTFRSILAS LTALIVGLLC GPLMIRWLRG
60 70 80 90 100
LQIGQMVRSD GPQTHLSKAG TPTMGGVLIL LAITVSCLLW CDLRQTSLWL
110 120 130 140 150
VLLVTLANGL VGWVDDYRKL VLKNSKGLPG RWKYFWQSVI ALVAVSYLYW
160 170 180 190 200
NASLPVHTQL TVPFFKTVTW DLGVFFPVLA YFVIVGSSNA VNLTDGLDGL
210 220 230 240 250
AIMPIVMVAG ALGVFAYASS NAVYSNYLGI PYVPNTGELT IFCSSIVGAG
260 270 280 290 300
LGFLWYNSYP AQVFMGDVGS LALGAALGIV AVVVRQELVL LIMGGLFVIE
310 320 330 340 350
TLSVILQVGY FKYSGGKRLF RMAPLHHHFE LKGWSEPKVI VRFWIITVVF
360
VLCGLATLKL R
Length:361
Mass (Da):39,854
Last modified:March 15, 2005 - v2
Checksum:i3330050916969E9B
GO

Sequence cautioni

The sequence AAU28675 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA Translation: AAU28675.1 Different initiation.
RefSeqiYP_096622.1, NC_002942.5

Genome annotation databases

EnsemblBacteriaiAAU28675; AAU28675; lpg2617
GeneIDi19834182
KEGGilpn:lpg2617
PATRICifig|272624.6.peg.2792

Entry informationi

Entry nameiMRAY_LEGPH
AccessioniPrimary (citable) accession number: Q5ZSA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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