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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei599 – 5991For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-2834-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:lpg2836
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000609 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 604603Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135346Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272624.lpg2836.

Structurei

3D structure databases

ProteinModelPortaliQ5ZRP4.
SMRiQ5ZRP4. Positions 2-604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini279 – 427149SIS 1UniRule annotationAdd
BLAST
Domaini454 – 594141SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiSEFRYAP.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZRP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIMGAVSE RDISKILLEG LRRLEYRGYD SAGIAVIDSQ DRLKRVRIQG
60 70 80 90 100
KVQNLADAMQ ETAIAGNTGI AHTRWATHGK PSEQNAHPHL SHGEIALVHN
110 120 130 140 150
GIIENHEHLR QQLITYGYQF TSETDTEVAA HLIHYHYQQH ENLLLAVQKA
160 170 180 190 200
AAEMQGAFAL GVIHQKRPEE LVAIRKGSPL VLGFGIGENF IASDALALRS
210 220 230 240 250
FAQSVIYMEE GDSACVTTQD IKVYDSNRIL VQRAVHPLNS DSEIVNKGPY
260 270 280 290 300
RHFMLKEIFE QSKVITDTLE SRINSIDVLR ASFGEKASHI FPVVKNIHIV
310 320 330 340 350
ACGTSYHAGM IAKYWLESLA GLPTQVEIAS EYRYRDVVVP DNTLFITVSQ
360 370 380 390 400
SGETADTLAA LFKAKQSNYL ASLAICNVAT STLVREADCV FLTRAGIEIG
410 420 430 440 450
VASTKAFTTQ LAAFLMLAAA LCKDNRAQEV LRQLQELPAC CERVLQMNEE
460 470 480 490 500
VESLASLFVN KVHALFLGRG VQYPVALEGA LKLKEISYIH AEAYPAGELK
510 520 530 540 550
HGPLALVDKD MPVIAVAPND ELLDKLKSNL HEVSARGGQL FVFVDDSQNW
560 570 580 590 600
KANGARLIKV PSCGAWLAPI VYTIPLQLLA YHVAVAKGTD VDQPRNLAKS

VTVE
Length:604
Mass (Da):66,360
Last modified:January 22, 2007 - v3
Checksum:i259A8A66F9ECD954
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU28884.1.
RefSeqiYP_096831.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU28884; AAU28884; lpg2836.
GeneIDi19834401.
KEGGilpn:lpg2836.
PATRICi22333053. VBILegPne29832_3021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU28884.1.
RefSeqiYP_096831.1. NC_002942.5.

3D structure databases

ProteinModelPortaliQ5ZRP4.
SMRiQ5ZRP4. Positions 2-604.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272624.lpg2836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU28884; AAU28884; lpg2836.
GeneIDi19834401.
KEGGilpn:lpg2836.
PATRICi22333053. VBILegPne29832_3021.

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiSEFRYAP.
OrthoDBiEOG6KT2Q1.

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-2834-MONOMER.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

Entry informationi

Entry nameiGLMS_LEGPH
AccessioniPrimary (citable) accession number: Q5ZRP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2005
Last sequence update: January 22, 2007
Last modified: January 6, 2015
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.