ID   APAH_LEGPH              Reviewed;         276 AA.
AC   Q5ZRF6;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 2.
DT   24-MAR-2009, entry version 25.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical;
DE            EC=3.6.1.41;
DE   AltName: Full=Diadenosine tetraphosphatase;
DE   AltName: Full=Ap4A hydrolase;
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase;
GN   Name=apaH; OrderedLocusNames=lpg2926;
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 /
OS   ATCC 33152 / DSM 7513).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=272624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M.,
RA   Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J.,
RA   Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R.,
RA   Pampou S., Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E.,
RA   Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G.,
RA   Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J.,
RA   Ju J., Kalachikov S., Shuman H.A., Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella
RT   pneumophila.";
RL   Science 305:1966-1968(2004).
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
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DR   EMBL; AE017354; AAU28972.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_096919.1; -.
DR   GeneID; 3079641; -.
DR   GenomeReviews; AE017354_GR; lpg2926.
DR   KEGG; lpn:lpg2926; -.
DR   NMPDR; fig|272624.3.peg.2864; -.
DR   HOGENOM; Q5ZRF6; -.
DR   BioCyc; LPNE272624:LPG2926-MON; -.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetr...; IEA:HAMAP.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    276       Bis(5'-nucleosyl)-tetraphosphatase,
FT                                symmetrical.
FT                                /FTId=PRO_0000197996.
SQ   SEQUENCE   276 AA;  31453 MW;  FDCC154C305189D8 CRC64;
     MPDYAIGDVQ GCYDPLQRLL ELIDFNEKED CLWFVGDLVN RGPDSLAVLR FIYSLPVKPK
     ITLGNHDLHL LGLLFGGQPW KGHDDTLEEV MLADDGEELG HWLRKQSLLC RSSELNIVMC
     HAGIAPLWDL SKAMDLANEL EAVLSGDSYH EFFAQMYGNK PDIWSDDLVG LDRLRVITNY
     FTRMRYCDAH GRLDLGYKGT LSKAPNHLYP WFEVPCRKEI EMDIVFGHWA ALMGRSSHPR
     IHAIDTGCLW GGQLTALRLQ DRQRFSVPGY GVSRFE
//