Reviewed, UniProtKB/Swiss-Prot Q5ZRF6 (APAH_LEGPH)

Names and origin

Protein names

Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
    EC=3.6.1.41
Alternative name(s):
    Diadenosine tetraphosphatase
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase

Gene names

Name:	apaH
Ordered Locus Names:	lpg2926

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_0000197996

Sequences

	Sequence		Length	Mass (Da)
	Q5ZRF6-1 [UniParc]. Last modified March 1, 2005. Version 2. Checksum: FDCC154C305189D8	FASTA	276	31,453
	10 20 30 40 50 60 MPDYAIGDVQ GCYDPLQRLL ELIDFNEKED CLWFVGDLVN RGPDSLAVLR FIYSLPVKPK 70 80 90 100 110 120 ITLGNHDLHL LGLLFGGQPW KGHDDTLEEV MLADDGEELG HWLRKQSLLC RSSELNIVMC 130 140 150 160 170 180 HAGIAPLWDL SKAMDLANEL EAVLSGDSYH EFFAQMYGNK PDIWSDDLVG LDRLRVITNY 190 200 210 220 230 240 FTRMRYCDAH GRLDLGYKGT LSKAPNHLYP WFEVPCRKEI EMDIVFGHWA ALMGRSSHPR 250 260 270 IHAIDTGCLW GGQLTALRLQ DRQRFSVPGY GVSRFE

References

[1]

"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J. Science 305:1966-1968(2004) [PubMed: 15448271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017354 Genomic DNA. Translation: AAU28972.1. Different initiation.
RefSeq	YP_096919.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3079641.
GenomeReviews	Gene locus lpg2926 in contig AE017354_GR.
KEGG	lpn:lpg2926.
NMPDR	fig|272624.3.peg.2864.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5ZRF6.
Enzyme and pathway databases
BioCyc	LPNE272624:LPG2926-MON.
Family and domain databases
HAMAP	MF_00199. [Tree]
InterPro	IPR004617. ApaH. IPR004843. M-pesterase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_LEGPH

Accession

Primary (citable) accession number: Q5ZRF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	March 24, 2009
This is version 25 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)