Q5ZRF6 (APAH_LEGPH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	lpg2926

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.
Sequence caution	The sequence AAU28972.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_0000197996

Sequences

	Sequence		Length	Mass (Da)
	Q5ZRF6 [UniParc]. Last modified March 1, 2005. Version 2. Checksum: FDCC154C305189D8	FASTA	276	31,453
	10 20 30 40 50 60 MPDYAIGDVQ GCYDPLQRLL ELIDFNEKED CLWFVGDLVN RGPDSLAVLR FIYSLPVKPK 70 80 90 100 110 120 ITLGNHDLHL LGLLFGGQPW KGHDDTLEEV MLADDGEELG HWLRKQSLLC RSSELNIVMC 130 140 150 160 170 180 HAGIAPLWDL SKAMDLANEL EAVLSGDSYH EFFAQMYGNK PDIWSDDLVG LDRLRVITNY 190 200 210 220 230 240 FTRMRYCDAH GRLDLGYKGT LSKAPNHLYP WFEVPCRKEI EMDIVFGHWA ALMGRSSHPR 250 260 270 IHAIDTGCLW GGQLTALRLQ DRQRFSVPGY GVSRFE

References

[1]

"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J. Science 305:1966-1968(2004) [PubMed: 15448271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017354 Genomic DNA. Translation: AAU28972.1. Different initiation.
RefSeq	YP_096919.1. NC_002942.5.
3D structure databases
ProteinModelPortal	Q5ZRF6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZRF6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3079641.
GenomeReviews	Gene locus lpg2926 in contig AE017354_GR.
KEGG	lpn:lpg2926.
NMPDR	fig|272624.3.peg.2864.
PATRIC	22333259. VBILegPne29832_3124.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HBG724457.
PhylomeDB	Q5ZRF6.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	LPNE272624:LPG2926-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH. [Tree]
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. ApaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_LEGPH

Accession

Primary (citable) accession number: Q5ZRF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program