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Q5ZRD7

- LPXB2_LEGPH

UniProt

Q5ZRD7 - LPXB2_LEGPH

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Protein

Lipid-A-disaccharide synthase 2

Gene

lpxB2

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-2943-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase 2UniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxB2UniRule annotation
Ordered Locus Names:lpg2945
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000609: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Lipid-A-disaccharide synthase 2PRO_0000255195Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272624.lpg2945.

Structurei

3D structure databases

ProteinModelPortaliQ5ZRD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiEWTINPP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZRD7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMKRPTRIA MVAGELSGDL LGAGVIRELK QHLTNVEFMG VGGPQMLKEG
60 70 80 90 100
FHSLIDISEL SVMGISDVLR RYPQLYLIRE RLLREWTINP PDVFIGIDYP
110 120 130 140 150
DFNLSVEARL KKQHIKTIHL VSPKVWAWRQ KRVHLIKKAV DLVLTLFPFE
160 170 180 190 200
EAFYRQHGVS AQFIGHPLAD LIEINPSCST LRKKYNYHSD DTILAVLPGS
210 220 230 240 250
RVGEIKYMGP LFLEVMQRIA VERPHVHFIV PIACQDLYPV FFKQLHAEYG
260 270 280 290 300
HLKIQIIQGN AREAMAISDV VLTKSGTATL EAMLLKRPMV VAFKWGILTH
310 320 330 340 350
AIIAPQVKVP YIALPNLLAG KKLIPEFVQE KANVDSITES VLNLLDSSNQ
360 370 380
NELIKQFTDI HCTLRQNANE KAALSILRIL GTSLT
Length:385
Mass (Da):43,476
Last modified:November 23, 2004 - v1
Checksum:i0101A96F4DA538F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU28991.1.
RefSeqiYP_096938.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU28991; AAU28991; lpg2945.
GeneIDi19834510.
KEGGilpn:lpg2945.
PATRICi22333301. VBILegPne29832_3145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA. Translation: AAU28991.1 .
RefSeqi YP_096938.1. NC_002942.5.

3D structure databases

ProteinModelPortali Q5ZRD7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272624.lpg2945.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU28991 ; AAU28991 ; lpg2945 .
GeneIDi 19834510.
KEGGi lpn:lpg2945.
PATRICi 22333301. VBILegPne29832_3145.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi EWTINPP.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci LPNE272624:GHDI-2943-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

Entry informationi

Entry nameiLPXB2_LEGPH
AccessioniPrimary (citable) accession number: Q5ZRD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3