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Q5ZRD7

- LPXB2_LEGPH

UniProt

Q5ZRD7 - LPXB2_LEGPH

Protein

Lipid-A-disaccharide synthase 2

Gene

lpxB2

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciLPNE272624:GHDI-2943-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase 2UniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxB2UniRule annotation
    Ordered Locus Names:lpg2945
    OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
    Taxonomic identifieri272624 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000000609: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385Lipid-A-disaccharide synthase 2PRO_0000255195Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272624.lpg2945.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZRD7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiEWTINPP.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5ZRD7-1 [UniParc]FASTAAdd to Basket

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    MTMKRPTRIA MVAGELSGDL LGAGVIRELK QHLTNVEFMG VGGPQMLKEG    50
    FHSLIDISEL SVMGISDVLR RYPQLYLIRE RLLREWTINP PDVFIGIDYP 100
    DFNLSVEARL KKQHIKTIHL VSPKVWAWRQ KRVHLIKKAV DLVLTLFPFE 150
    EAFYRQHGVS AQFIGHPLAD LIEINPSCST LRKKYNYHSD DTILAVLPGS 200
    RVGEIKYMGP LFLEVMQRIA VERPHVHFIV PIACQDLYPV FFKQLHAEYG 250
    HLKIQIIQGN AREAMAISDV VLTKSGTATL EAMLLKRPMV VAFKWGILTH 300
    AIIAPQVKVP YIALPNLLAG KKLIPEFVQE KANVDSITES VLNLLDSSNQ 350
    NELIKQFTDI HCTLRQNANE KAALSILRIL GTSLT 385
    Length:385
    Mass (Da):43,476
    Last modified:November 23, 2004 - v1
    Checksum:i0101A96F4DA538F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017354 Genomic DNA. Translation: AAU28991.1.
    RefSeqiYP_096938.1. NC_002942.5.

    Genome annotation databases

    EnsemblBacteriaiAAU28991; AAU28991; lpg2945.
    GeneIDi3079995.
    KEGGilpn:lpg2945.
    PATRICi22333301. VBILegPne29832_3145.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017354 Genomic DNA. Translation: AAU28991.1 .
    RefSeqi YP_096938.1. NC_002942.5.

    3D structure databases

    ProteinModelPortali Q5ZRD7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272624.lpg2945.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU28991 ; AAU28991 ; lpg2945 .
    GeneIDi 3079995.
    KEGGi lpn:lpg2945.
    PATRICi 22333301. VBILegPne29832_3145.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi EWTINPP.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci LPNE272624:GHDI-2943-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

    Entry informationi

    Entry nameiLPXB2_LEGPH
    AccessioniPrimary (citable) accession number: Q5ZRD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3