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Q5ZPR3

- CD276_HUMAN

UniProt

Q5ZPR3 - CD276_HUMAN

Protein

CD276 antigen

Gene

CD276

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.6 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. receptor binding Source: HGNC

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. immune response Source: UniProtKB
    3. negative regulation of inflammatory response Source: Ensembl
    4. negative regulation of interferon-gamma biosynthetic process Source: Ensembl
    5. negative regulation of interleukin-2 biosynthetic process Source: Ensembl
    6. negative regulation of T cell proliferation Source: Ensembl
    7. positive regulation of bone mineralization Source: Ensembl
    8. positive regulation of interferon-gamma biosynthetic process Source: HGNC
    9. positive regulation of osteoblast differentiation Source: Ensembl
    10. positive regulation of T cell proliferation Source: HGNC
    11. regulation of immune response Source: HGNC
    12. T cell activation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD276 antigen
    Alternative name(s):
    4Ig-B7-H3
    B7 homolog 3
    Short name:
    B7-H3
    Costimulatory molecule
    CD_antigen: CD276
    Gene namesi
    Name:CD276
    Synonyms:B7H3
    ORF Names:PSEC0249, UNQ309/PRO352
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:19137. CD276.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: HGNC
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: HGNC

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672148.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28281 PublicationAdd
    BLAST
    Chaini29 – 534506CD276 antigenPRO_0000045801Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 122PROSITE-ProRule annotation
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi165 ↔ 220PROSITE-ProRule annotation
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi268 ↔ 340PROSITE-ProRule annotation
    Glycosylationi322 – 3221N-linked (GlcNAc...)1 Publication
    Disulfide bondi383 ↔ 438PROSITE-ProRule annotation
    Glycosylationi407 – 4071N-linked (GlcNAc...)1 Publication
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Modified residuei525 – 5251Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ5ZPR3.
    PaxDbiQ5ZPR3.
    PRIDEiQ5ZPR3.

    PTM databases

    PhosphoSiteiQ5ZPR3.

    Expressioni

    Tissue specificityi

    Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.5 Publications

    Inductioni

    By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants.2 Publications

    Gene expression databases

    ArrayExpressiQ5ZPR3.
    BgeeiQ5ZPR3.
    CleanExiHS_CD276.
    GenevestigatoriQ5ZPR3.

    Organism-specific databases

    HPAiCAB017826.
    HPA009285.
    HPA017139.

    Interactioni

    Subunit structurei

    Interacts with TREML2 and this interaction enhances T-cell activation.1 Publication

    Protein-protein interaction databases

    BioGridi123260. 2 interactions.
    IntActiQ5ZPR3. 1 interaction.
    MINTiMINT-5000152.
    STRINGi9606.ENSP00000320084.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZPR3.
    SMRiQ5ZPR3. Positions 35-457.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 466438ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini488 – 53447CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei467 – 48721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 139111Ig-like V-type 1Add
    BLAST
    Domaini145 – 23894Ig-like C2-type 1Add
    BLAST
    Domaini243 – 357115Ig-like V-type 2Add
    BLAST
    Domaini363 – 45694Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG85729.
    HOVERGENiHBG079786.
    InParanoidiQ5ZPR3.
    KOiK06746.
    OMAiAHSSVTI.
    OrthoDBiEOG7FBRH9.
    PhylomeDBiQ5ZPR3.
    TreeFamiTF331083.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF08205. C2-set_2. 2 hits.
    PF07686. V-set. 2 hits.
    [Graphical view]
    SMARTiSM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5ZPR3-1) [UniParc]FASTAAdd to Basket

    Also known as: 4Ig-B7-H3

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC    50
    SFSPEPGFSL AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL 100
    AQGNASLRLQ RVRVADEGSF TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE 150
    PNKDLRPGDT VTITCSSYQG YPEAEVFWQD GQGVPLTGNV TTSQMANEQG 200
    LFDVHSILRV VLGANGTYSC LVRNPVLQQD AHSSVTITPQ RSPTGAVEVQ 250
    VPEDPVVALV GTDATLRCSF SPEPGFSLAQ LNLIWQLTDT KQLVHSFTEG 300
    RDQGSAYANR TALFPDLLAQ GNASLRLQRV RVADEGSFTC FVSIRDFGSA 350
    AVSLQVAAPY SKPSMTLEPN KDLRPGDTVT ITCSSYRGYP EAEVFWQDGQ 400
    GVPLTGNVTT SQMANEQGLF DVHSVLRVVL GANGTYSCLV RNPVLQQDAH 450
    GSVTITGQPM TFPPEALWVT VGLSVCLIAL LVALAFVCWR KIKQSCEEEN 500
    AGAEDQDGEG EGSKTALQPL KHSDSKEDDG QEIA 534

    Note: Contains tandemly repeated immunoglobulin-like V and C domains.

    Length:534
    Mass (Da):57,235
    Last modified:November 23, 2004 - v1
    Checksum:i2181A064404C7939
    GO
    Isoform 2 (identifier: Q5ZPR3-2) [UniParc]FASTAAdd to Basket

    Also known as: B7-H3

    The sequence of this isoform differs from the canonical sequence as follows:
         159-376: Missing.

    Note: Minor transcript. Contains one single set of immunoglobulin-like V and C domains.

    Show »
    Length:316
    Mass (Da):33,791
    Checksum:iFF97007F191CCFA1
    GO
    Isoform 3 (identifier: Q5ZPR3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         465-493: EALWVTVGLSVCLIALLVALAFVCWRKIK → GPASSAVPLSPAHPPHGSMCWSHWFSRGL
         494-534: Missing.

    Note: Contains tandemly repeated immunoglobulin-like V and C domains.

    Show »
    Length:493
    Mass (Da):52,761
    Checksum:iCD7C5591CC4822D2
    GO
    Isoform 4 (identifier: Q5ZPR3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         528-534: DDGQEIA → GKDTWA

    Note: Contains tandemly repeated immunoglobulin-like V and C domains.

    Show »
    Length:533
    Mass (Da):57,165
    Checksum:iBC38033295EBE978
    GO

    Sequence cautioni

    The sequence BAC11344.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti387 – 3871R → Q in AAQ88709. (PubMed:12975309)Curated
    Sequence conflicti473 – 4731L → P in BAC11243. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti97 – 971P → L.
    Corresponds to variant rs7173448 [ dbSNP | Ensembl ].
    VAR_049857
    Natural varianti111 – 1111R → S.
    Corresponds to variant rs7173476 [ dbSNP | Ensembl ].
    VAR_049858
    Natural varianti137 – 1371Q → L.
    Corresponds to variant rs11574477 [ dbSNP | Ensembl ].
    VAR_049859
    Natural varianti160 – 1601T → M.2 Publications
    Corresponds to variant rs11574479 [ dbSNP | Ensembl ].
    VAR_049860
    Natural varianti267 – 2671R → H.
    Corresponds to variant rs11574483 [ dbSNP | Ensembl ].
    VAR_049861
    Natural varianti279 – 2791A → T.
    Corresponds to variant rs10083681 [ dbSNP | Ensembl ].
    VAR_049862
    Natural varianti315 – 3151P → L.
    Corresponds to variant rs7173448 [ dbSNP | Ensembl ].
    VAR_049863
    Natural varianti329 – 3291R → S.
    Corresponds to variant rs7173476 [ dbSNP | Ensembl ].
    VAR_049864
    Natural varianti378 – 3781T → M.
    Corresponds to variant rs11574479 [ dbSNP | Ensembl ].
    VAR_049865

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei159 – 376218Missing in isoform 2. 2 PublicationsVSP_017088Add
    BLAST
    Alternative sequencei465 – 49329EALWV…WRKIK → GPASSAVPLSPAHPPHGSMC WSHWFSRGL in isoform 3. 1 PublicationVSP_017089Add
    BLAST
    Alternative sequencei494 – 53441Missing in isoform 3. 1 PublicationVSP_017090Add
    BLAST
    Alternative sequencei528 – 5347DDGQEIA → GKDTWA in isoform 4. 1 PublicationVSP_017091

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF302102 mRNA. Translation: AAK15438.1.
    AJ583695 mRNA. Translation: CAE47548.1.
    AY358343 mRNA. Translation: AAQ88709.1.
    AK074849 mRNA. Translation: BAC11243.1.
    AK074997 mRNA. Translation: BAC11344.1. Different initiation.
    AK075549 mRNA. Translation: BAC11692.1.
    BC062581 mRNA. Translation: AAH62581.1.
    CCDSiCCDS10251.1. [Q5ZPR3-2]
    CCDS32288.1. [Q5ZPR3-1]
    RefSeqiNP_001019907.1. NM_001024736.1. [Q5ZPR3-1]
    NP_079516.1. NM_025240.2. [Q5ZPR3-2]
    XP_005254757.1. XM_005254700.2.
    UniGeneiHs.744915.

    Genome annotation databases

    EnsembliENST00000318424; ENSP00000320058; ENSG00000103855. [Q5ZPR3-2]
    ENST00000318443; ENSP00000320084; ENSG00000103855. [Q5ZPR3-1]
    ENST00000537340; ENSP00000441087; ENSG00000103855.
    ENST00000561213; ENSP00000452736; ENSG00000103855. [Q5ZPR3-4]
    ENST00000564751; ENSP00000454940; ENSG00000103855. [Q5ZPR3-2]
    GeneIDi80381.
    KEGGihsa:80381.
    UCSCiuc002avu.1. human. [Q5ZPR3-4]
    uc002avv.1. human. [Q5ZPR3-1]
    uc002avw.1. human. [Q5ZPR3-2]

    Polymorphism databases

    DMDMi74757248.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF302102 mRNA. Translation: AAK15438.1 .
    AJ583695 mRNA. Translation: CAE47548.1 .
    AY358343 mRNA. Translation: AAQ88709.1 .
    AK074849 mRNA. Translation: BAC11243.1 .
    AK074997 mRNA. Translation: BAC11344.1 . Different initiation.
    AK075549 mRNA. Translation: BAC11692.1 .
    BC062581 mRNA. Translation: AAH62581.1 .
    CCDSi CCDS10251.1. [Q5ZPR3-2 ]
    CCDS32288.1. [Q5ZPR3-1 ]
    RefSeqi NP_001019907.1. NM_001024736.1. [Q5ZPR3-1 ]
    NP_079516.1. NM_025240.2. [Q5ZPR3-2 ]
    XP_005254757.1. XM_005254700.2.
    UniGenei Hs.744915.

    3D structure databases

    ProteinModelPortali Q5ZPR3.
    SMRi Q5ZPR3. Positions 35-457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123260. 2 interactions.
    IntActi Q5ZPR3. 1 interaction.
    MINTi MINT-5000152.
    STRINGi 9606.ENSP00000320084.

    PTM databases

    PhosphoSitei Q5ZPR3.

    Polymorphism databases

    DMDMi 74757248.

    Proteomic databases

    MaxQBi Q5ZPR3.
    PaxDbi Q5ZPR3.
    PRIDEi Q5ZPR3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318424 ; ENSP00000320058 ; ENSG00000103855 . [Q5ZPR3-2 ]
    ENST00000318443 ; ENSP00000320084 ; ENSG00000103855 . [Q5ZPR3-1 ]
    ENST00000537340 ; ENSP00000441087 ; ENSG00000103855 .
    ENST00000561213 ; ENSP00000452736 ; ENSG00000103855 . [Q5ZPR3-4 ]
    ENST00000564751 ; ENSP00000454940 ; ENSG00000103855 . [Q5ZPR3-2 ]
    GeneIDi 80381.
    KEGGi hsa:80381.
    UCSCi uc002avu.1. human. [Q5ZPR3-4 ]
    uc002avv.1. human. [Q5ZPR3-1 ]
    uc002avw.1. human. [Q5ZPR3-2 ]

    Organism-specific databases

    CTDi 80381.
    GeneCardsi GC15P073976.
    HGNCi HGNC:19137. CD276.
    HPAi CAB017826.
    HPA009285.
    HPA017139.
    MIMi 605715. gene.
    neXtProti NX_Q5ZPR3.
    PharmGKBi PA142672148.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85729.
    HOVERGENi HBG079786.
    InParanoidi Q5ZPR3.
    KOi K06746.
    OMAi AHSSVTI.
    OrthoDBi EOG7FBRH9.
    PhylomeDBi Q5ZPR3.
    TreeFami TF331083.

    Miscellaneous databases

    GeneWikii CD276.
    GenomeRNAii 80381.
    NextBioi 70980.
    PROi Q5ZPR3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5ZPR3.
    Bgeei Q5ZPR3.
    CleanExi HS_CD276.
    Genevestigatori Q5ZPR3.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 2 hits.
    PF07686. V-set. 2 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production."
      Chapoval A.I., Ni J., Lau J.S., Wilcox R.A., Flies D.B., Liu D., Dong H., Sica G.L., Zhu G., Tamada K., Chen L.
      Nat. Immunol. 2:269-274(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, FUNCTION.
    2. "Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains."
      Steinberger P., Majdic O., Derdak S.V., Pfistershammer K., Kirchberger S., Klauser C., Zlabinger G., Pickl W.F., Stockl J., Knapp W.
      J. Immunol. 172:2352-2359(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, INDUCTION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-534 (ISOFORM 1), VARIANT MET-160.
    5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-160.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Lung.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-43.
    8. "Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss."
      Ling V., Wu P.W., Spaulding V., Kieleczawa J., Luxenberg D., Carreno B.M., Collins M.
      Genomics 82:365-377(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, GENOMIC DOMAIN DUPLICATION.
    9. "Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis."
      Castriconi R., Dondero A., Augugliaro R., Cantoni C., Carnemolla B., Sementa A.R., Negri F., Conte R., Corrias M.V., Moretta L., Moretta A., Bottino C.
      Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta."
      Petroff M.G., Kharatyan E., Torry D.S., Holets L.
      Am. J. Pathol. 167:465-473(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Constitutive and inducible expression of B7 family of ligands by human airway epithelial cells."
      Kim J., Myers A.C., Chen L., Pardoll D.M., Truong-Tran Q.A., Lane A.P., McDyer J.F., Fortuno L., Schleimer R.P.
      Am. J. Respir. Cell Mol. Biol. 33:280-289(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    12. "B7-H3: another molecule marker for Mo-DCs?"
      Zhang G.B., Dong Q.M., Xu Y., Yu G.H., Zhang X.G.
      Cell. Mol. Immunol. 2:307-311(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    13. Cited for: FUNCTION, INDUCTION.
    14. "Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses."
      Hashiguchi M., Kobori H., Ritprajak P., Kamimura Y., Kozono H., Azuma M.
      Proc. Natl. Acad. Sci. U.S.A. 105:10495-10500(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TREML2.
    15. Erratum
      Hashiguchi M., Kobori H., Ritprajak P., Kamimura Y., Kozono H., Azuma M.
      Proc. Natl. Acad. Sci. U.S.A. 105:14744-14744(2008)
    16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-322 AND ASN-407.
      Tissue: Liver.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCD276_HUMAN
    AccessioniPrimary (citable) accession number: Q5ZPR3
    Secondary accession number(s): Q6P5Y4
    , Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey species.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3