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Q5ZPR3

- CD276_HUMAN

UniProt

Q5ZPR3 - CD276_HUMAN

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Protein

CD276 antigen

Gene

CD276

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.6 Publications

GO - Molecular functioni

  1. receptor binding Source: HGNC

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. immune response Source: UniProtKB
  3. negative regulation of inflammatory response Source: Ensembl
  4. negative regulation of interferon-gamma biosynthetic process Source: Ensembl
  5. negative regulation of interleukin-2 biosynthetic process Source: Ensembl
  6. negative regulation of T cell proliferation Source: Ensembl
  7. positive regulation of bone mineralization Source: Ensembl
  8. positive regulation of interferon-gamma biosynthetic process Source: HGNC
  9. positive regulation of interleukin-2 secretion Source: Ensembl
  10. positive regulation of osteoblast differentiation Source: Ensembl
  11. positive regulation of T cell proliferation Source: HGNC
  12. regulation of immune response Source: HGNC
  13. T cell activation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CD276 antigen
Alternative name(s):
4Ig-B7-H3
B7 homolog 3
Short name:
B7-H3
Costimulatory molecule
CD_antigen: CD276
Gene namesi
Name:CD276
Synonyms:B7H3
ORF Names:PSEC0249, UNQ309/PRO352
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:19137. CD276.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: HGNC
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672148.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Chaini29 – 534506CD276 antigenPRO_0000045801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 122PROSITE-ProRule annotation
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi165 ↔ 220PROSITE-ProRule annotation
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi268 ↔ 340PROSITE-ProRule annotation
Glycosylationi322 – 3221N-linked (GlcNAc...)1 Publication
Disulfide bondi383 ↔ 438PROSITE-ProRule annotation
Glycosylationi407 – 4071N-linked (GlcNAc...)1 Publication
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Modified residuei525 – 5251Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ5ZPR3.
PaxDbiQ5ZPR3.
PRIDEiQ5ZPR3.

PTM databases

PhosphoSiteiQ5ZPR3.

Expressioni

Tissue specificityi

Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.5 Publications

Inductioni

By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants.2 Publications

Gene expression databases

BgeeiQ5ZPR3.
CleanExiHS_CD276.
ExpressionAtlasiQ5ZPR3. baseline and differential.
GenevestigatoriQ5ZPR3.

Organism-specific databases

HPAiCAB017826.
HPA009285.
HPA017139.

Interactioni

Subunit structurei

Interacts with TREML2 and this interaction enhances T-cell activation.1 Publication

Protein-protein interaction databases

BioGridi123260. 4 interactions.
IntActiQ5ZPR3. 1 interaction.
MINTiMINT-5000152.
STRINGi9606.ENSP00000320084.

Structurei

3D structure databases

ProteinModelPortaliQ5ZPR3.
SMRiQ5ZPR3. Positions 35-497.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 466438ExtracellularSequence AnalysisAdd
BLAST
Topological domaini488 – 53447CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei467 – 48721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 139111Ig-like V-type 1Add
BLAST
Domaini145 – 23894Ig-like C2-type 1Add
BLAST
Domaini243 – 357115Ig-like V-type 2Add
BLAST
Domaini363 – 45694Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85729.
GeneTreeiENSGT00700000104325.
HOVERGENiHBG079786.
InParanoidiQ5ZPR3.
KOiK06746.
OMAiAHSSVTI.
OrthoDBiEOG7FBRH9.
PhylomeDBiQ5ZPR3.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 2 hits.
PF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5ZPR3-1) [UniParc]FASTAAdd to Basket

Also known as: 4Ig-B7-H3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC
60 70 80 90 100
SFSPEPGFSL AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL
110 120 130 140 150
AQGNASLRLQ RVRVADEGSF TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE
160 170 180 190 200
PNKDLRPGDT VTITCSSYQG YPEAEVFWQD GQGVPLTGNV TTSQMANEQG
210 220 230 240 250
LFDVHSILRV VLGANGTYSC LVRNPVLQQD AHSSVTITPQ RSPTGAVEVQ
260 270 280 290 300
VPEDPVVALV GTDATLRCSF SPEPGFSLAQ LNLIWQLTDT KQLVHSFTEG
310 320 330 340 350
RDQGSAYANR TALFPDLLAQ GNASLRLQRV RVADEGSFTC FVSIRDFGSA
360 370 380 390 400
AVSLQVAAPY SKPSMTLEPN KDLRPGDTVT ITCSSYRGYP EAEVFWQDGQ
410 420 430 440 450
GVPLTGNVTT SQMANEQGLF DVHSVLRVVL GANGTYSCLV RNPVLQQDAH
460 470 480 490 500
GSVTITGQPM TFPPEALWVT VGLSVCLIAL LVALAFVCWR KIKQSCEEEN
510 520 530
AGAEDQDGEG EGSKTALQPL KHSDSKEDDG QEIA

Note: Contains tandemly repeated immunoglobulin-like V and C domains.

Length:534
Mass (Da):57,235
Last modified:November 23, 2004 - v1
Checksum:i2181A064404C7939
GO
Isoform 2 (identifier: Q5ZPR3-2) [UniParc]FASTAAdd to Basket

Also known as: B7-H3

The sequence of this isoform differs from the canonical sequence as follows:
     159-376: Missing.

Note: Minor transcript. Contains one single set of immunoglobulin-like V and C domains.

Show »
Length:316
Mass (Da):33,791
Checksum:iFF97007F191CCFA1
GO
Isoform 3 (identifier: Q5ZPR3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-493: EALWVTVGLSVCLIALLVALAFVCWRKIK → GPASSAVPLSPAHPPHGSMCWSHWFSRGL
     494-534: Missing.

Note: Contains tandemly repeated immunoglobulin-like V and C domains.

Show »
Length:493
Mass (Da):52,761
Checksum:iCD7C5591CC4822D2
GO
Isoform 4 (identifier: Q5ZPR3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-534: DDGQEIA → GKDTWA

Note: Contains tandemly repeated immunoglobulin-like V and C domains.

Show »
Length:533
Mass (Da):57,165
Checksum:iBC38033295EBE978
GO

Sequence cautioni

The sequence BAC11344.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti387 – 3871R → Q in AAQ88709. (PubMed:12975309)Curated
Sequence conflicti473 – 4731L → P in BAC11243. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971P → L.
Corresponds to variant rs7173448 [ dbSNP | Ensembl ].
VAR_049857
Natural varianti111 – 1111R → S.
Corresponds to variant rs7173476 [ dbSNP | Ensembl ].
VAR_049858
Natural varianti137 – 1371Q → L.
Corresponds to variant rs11574477 [ dbSNP | Ensembl ].
VAR_049859
Natural varianti160 – 1601T → M.2 Publications
Corresponds to variant rs11574479 [ dbSNP | Ensembl ].
VAR_049860
Natural varianti267 – 2671R → H.
Corresponds to variant rs11574483 [ dbSNP | Ensembl ].
VAR_049861
Natural varianti279 – 2791A → T.
Corresponds to variant rs10083681 [ dbSNP | Ensembl ].
VAR_049862
Natural varianti315 – 3151P → L.
Corresponds to variant rs7173448 [ dbSNP | Ensembl ].
VAR_049863
Natural varianti329 – 3291R → S.
Corresponds to variant rs7173476 [ dbSNP | Ensembl ].
VAR_049864
Natural varianti378 – 3781T → M.
Corresponds to variant rs11574479 [ dbSNP | Ensembl ].
VAR_049865

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei159 – 376218Missing in isoform 2. 2 PublicationsVSP_017088Add
BLAST
Alternative sequencei465 – 49329EALWV…WRKIK → GPASSAVPLSPAHPPHGSMC WSHWFSRGL in isoform 3. 1 PublicationVSP_017089Add
BLAST
Alternative sequencei494 – 53441Missing in isoform 3. 1 PublicationVSP_017090Add
BLAST
Alternative sequencei528 – 5347DDGQEIA → GKDTWA in isoform 4. 1 PublicationVSP_017091

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF302102 mRNA. Translation: AAK15438.1.
AJ583695 mRNA. Translation: CAE47548.1.
AY358343 mRNA. Translation: AAQ88709.1.
AK074849 mRNA. Translation: BAC11243.1.
AK074997 mRNA. Translation: BAC11344.1. Different initiation.
AK075549 mRNA. Translation: BAC11692.1.
BC062581 mRNA. Translation: AAH62581.1.
CCDSiCCDS10251.1. [Q5ZPR3-2]
CCDS32288.1. [Q5ZPR3-1]
RefSeqiNP_001019907.1. NM_001024736.1. [Q5ZPR3-1]
NP_079516.1. NM_025240.2. [Q5ZPR3-2]
XP_005254757.1. XM_005254700.2.
UniGeneiHs.744915.

Genome annotation databases

EnsembliENST00000318424; ENSP00000320058; ENSG00000103855. [Q5ZPR3-2]
ENST00000318443; ENSP00000320084; ENSG00000103855. [Q5ZPR3-1]
ENST00000537340; ENSP00000441087; ENSG00000103855.
ENST00000561213; ENSP00000452736; ENSG00000103855. [Q5ZPR3-4]
ENST00000564751; ENSP00000454940; ENSG00000103855. [Q5ZPR3-2]
GeneIDi80381.
KEGGihsa:80381.
UCSCiuc002avu.1. human. [Q5ZPR3-4]
uc002avv.1. human. [Q5ZPR3-1]
uc002avw.1. human. [Q5ZPR3-2]

Polymorphism databases

DMDMi74757248.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF302102 mRNA. Translation: AAK15438.1 .
AJ583695 mRNA. Translation: CAE47548.1 .
AY358343 mRNA. Translation: AAQ88709.1 .
AK074849 mRNA. Translation: BAC11243.1 .
AK074997 mRNA. Translation: BAC11344.1 . Different initiation.
AK075549 mRNA. Translation: BAC11692.1 .
BC062581 mRNA. Translation: AAH62581.1 .
CCDSi CCDS10251.1. [Q5ZPR3-2 ]
CCDS32288.1. [Q5ZPR3-1 ]
RefSeqi NP_001019907.1. NM_001024736.1. [Q5ZPR3-1 ]
NP_079516.1. NM_025240.2. [Q5ZPR3-2 ]
XP_005254757.1. XM_005254700.2.
UniGenei Hs.744915.

3D structure databases

ProteinModelPortali Q5ZPR3.
SMRi Q5ZPR3. Positions 35-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123260. 4 interactions.
IntActi Q5ZPR3. 1 interaction.
MINTi MINT-5000152.
STRINGi 9606.ENSP00000320084.

PTM databases

PhosphoSitei Q5ZPR3.

Polymorphism databases

DMDMi 74757248.

Proteomic databases

MaxQBi Q5ZPR3.
PaxDbi Q5ZPR3.
PRIDEi Q5ZPR3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318424 ; ENSP00000320058 ; ENSG00000103855 . [Q5ZPR3-2 ]
ENST00000318443 ; ENSP00000320084 ; ENSG00000103855 . [Q5ZPR3-1 ]
ENST00000537340 ; ENSP00000441087 ; ENSG00000103855 .
ENST00000561213 ; ENSP00000452736 ; ENSG00000103855 . [Q5ZPR3-4 ]
ENST00000564751 ; ENSP00000454940 ; ENSG00000103855 . [Q5ZPR3-2 ]
GeneIDi 80381.
KEGGi hsa:80381.
UCSCi uc002avu.1. human. [Q5ZPR3-4 ]
uc002avv.1. human. [Q5ZPR3-1 ]
uc002avw.1. human. [Q5ZPR3-2 ]

Organism-specific databases

CTDi 80381.
GeneCardsi GC15P073976.
HGNCi HGNC:19137. CD276.
HPAi CAB017826.
HPA009285.
HPA017139.
MIMi 605715. gene.
neXtProti NX_Q5ZPR3.
PharmGKBi PA142672148.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85729.
GeneTreei ENSGT00700000104325.
HOVERGENi HBG079786.
InParanoidi Q5ZPR3.
KOi K06746.
OMAi AHSSVTI.
OrthoDBi EOG7FBRH9.
PhylomeDBi Q5ZPR3.
TreeFami TF331083.

Miscellaneous databases

GeneWikii CD276.
GenomeRNAii 80381.
NextBioi 70980.
PROi Q5ZPR3.
SOURCEi Search...

Gene expression databases

Bgeei Q5ZPR3.
CleanExi HS_CD276.
ExpressionAtlasi Q5ZPR3. baseline and differential.
Genevestigatori Q5ZPR3.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF08205. C2-set_2. 2 hits.
PF07686. V-set. 2 hits.
[Graphical view ]
SMARTi SM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production."
    Chapoval A.I., Ni J., Lau J.S., Wilcox R.A., Flies D.B., Liu D., Dong H., Sica G.L., Zhu G., Tamada K., Chen L.
    Nat. Immunol. 2:269-274(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, FUNCTION.
  2. "Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains."
    Steinberger P., Majdic O., Derdak S.V., Pfistershammer K., Kirchberger S., Klauser C., Zlabinger G., Pickl W.F., Stockl J., Knapp W.
    J. Immunol. 172:2352-2359(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, INDUCTION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-534 (ISOFORM 1), VARIANT MET-160.
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-160.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Lung.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-43.
  8. "Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss."
    Ling V., Wu P.W., Spaulding V., Kieleczawa J., Luxenberg D., Carreno B.M., Collins M.
    Genomics 82:365-377(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GENOMIC DOMAIN DUPLICATION.
  9. "Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis."
    Castriconi R., Dondero A., Augugliaro R., Cantoni C., Carnemolla B., Sementa A.R., Negri F., Conte R., Corrias M.V., Moretta L., Moretta A., Bottino C.
    Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta."
    Petroff M.G., Kharatyan E., Torry D.S., Holets L.
    Am. J. Pathol. 167:465-473(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Constitutive and inducible expression of B7 family of ligands by human airway epithelial cells."
    Kim J., Myers A.C., Chen L., Pardoll D.M., Truong-Tran Q.A., Lane A.P., McDyer J.F., Fortuno L., Schleimer R.P.
    Am. J. Respir. Cell Mol. Biol. 33:280-289(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. "B7-H3: another molecule marker for Mo-DCs?"
    Zhang G.B., Dong Q.M., Xu Y., Yu G.H., Zhang X.G.
    Cell. Mol. Immunol. 2:307-311(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  13. Cited for: FUNCTION, INDUCTION.
  14. "Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses."
    Hashiguchi M., Kobori H., Ritprajak P., Kamimura Y., Kozono H., Azuma M.
    Proc. Natl. Acad. Sci. U.S.A. 105:10495-10500(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TREML2.
  15. Erratum
    Hashiguchi M., Kobori H., Ritprajak P., Kamimura Y., Kozono H., Azuma M.
    Proc. Natl. Acad. Sci. U.S.A. 105:14744-14744(2008)
  16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-322 AND ASN-407.
    Tissue: Liver.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCD276_HUMAN
AccessioniPrimary (citable) accession number: Q5ZPR3
Secondary accession number(s): Q6P5Y4
, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey species.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3