Q5ZPR3 (CD276_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CD276 antigen

Alternative name(s):
4Ig-B7-H3
B7 homolog 3
Short name=B7-H3
Costimulatory molecule
CD_antigen=CD276

Gene names

Name:	CD276
Synonyms:	B7H3
ORF Names:	PSEC0249, UNQ309/PRO352

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	534 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. Ref.1 Ref.2 Ref.8 Ref.9 Ref.11 Ref.13
Subunit structure	Interacts with TREML2 and this interaction enhances T-cell activation. Ref.14
Subcellular location	Membrane; Single-pass type I membrane protein Probable.
Tissue specificity	Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. Ref.1 Ref.2 Ref.10 Ref.11 Ref.12
Induction	By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants. Ref.2 Ref.13
Miscellaneous	B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey species.
Sequence similarities	Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Sequence caution	The sequence BAC11344.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	T cell activation Inferred from direct assay Ref.14. Source: UniProtKB cell proliferation Non-traceable author statement Ref.1. Source: UniProtKB immune response Non-traceable author statement Ref.1. Source: UniProtKB negative regulation of T cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of inflammatory response Inferred from electronic annotation. Source: Compara negative regulation of interferon-gamma biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of interleukin-2 biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of T cell proliferation Inferred from direct assay Ref.1. Source: HGNC positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma biosynthetic process Inferred from direct assay Ref.1. Source: HGNC positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara regulation of immune response Non-traceable author statement Ref.1. Source: HGNC
Cellular_component	external side of plasma membrane Non-traceable author statement PubMed 15188059. Source: HGNC integral to membrane Non-traceable author statement PubMed 15188059. Source: HGNC
Molecular_function	receptor binding Non-traceable author statement Ref.1. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5ZPR3-1)

Also known as: 4Ig-B7-H3;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Contains tandemly repeated immunoglobulin-like V and C domains.

Isoform 2 (identifier: Q5ZPR3-2)

Also known as: B7-H3;

The sequence of this isoform differs from the canonical sequence as follows:
     159-376: Missing.

Note: Minor transcript. Contains one single set of immunoglobulin-like V and C domains.

Isoform 3 (identifier: Q5ZPR3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     465-493: EALWVTVGLSVCLIALLVALAFVCWRKIK → GPASSAVPLSPAHPPHGSMCWSHWFSRGL
     494-534: Missing.

Note: Contains tandemly repeated immunoglobulin-like V and C domains.

Isoform 4 (identifier: Q5ZPR3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     528-534: DDGQEIA → GKDTWA

Note: Contains tandemly repeated immunoglobulin-like V and C domains.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Ref.7
	Chain	29 – 534	506	CD276 antigen		PRO_0000045801
Regions
	Topological domain	29 – 466	438	Extracellular Potential
	Transmembrane	467 – 487	21	Helical; Potential
	Topological domain	488 – 534	47	Cytoplasmic Potential
	Domain	29 – 139	111	Ig-like V-type 1
	Domain	145 – 238	94	Ig-like C2-type 1
	Domain	243 – 357	115	Ig-like V-type 2
	Domain	363 – 456	94	Ig-like C2-type 2
Amino acid modifications
	Modified residue	525	1	Phosphoserine Ref.16
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	189	1	N-linked (GlcNAc...) Potential
	Glycosylation	215	1	N-linked (GlcNAc...) Potential
	Glycosylation	322	1	N-linked (GlcNAc...) Ref.17
	Glycosylation	407	1	N-linked (GlcNAc...) Ref.17
	Glycosylation	433	1	N-linked (GlcNAc...) Potential
	Disulfide bond	50 ↔ 122		By similarity
	Disulfide bond	165 ↔ 220		By similarity
	Disulfide bond	268 ↔ 340		By similarity
	Disulfide bond	383 ↔ 438		By similarity
Natural variations
	Alternative sequence	159 – 376	218	Missing in isoform 2.		VSP_017088
	Alternative sequence	465 – 493	29	EALWV…WRKIK → GPASSAVPLSPAHPPHGSMC WSHWFSRGL in isoform 3.		VSP_017089
	Alternative sequence	494 – 534	41	Missing in isoform 3.		VSP_017090
	Alternative sequence	528 – 534	7	DDGQEIA → GKDTWA in isoform 4.		VSP_017091
	Natural variant	97	1	P → L. Corresponds to variant rs7173448 [ dbSNP | Ensembl ].		VAR_049857
	Natural variant	111	1	R → S. Corresponds to variant rs7173476 [ dbSNP | Ensembl ].		VAR_049858
	Natural variant	137	1	Q → L. Corresponds to variant rs11574477 [ dbSNP | Ensembl ].		VAR_049859
	Natural variant	160	1	T → M. Ref.4 Ref.5 Corresponds to variant rs11574479 [ dbSNP | Ensembl ].		VAR_049860
	Natural variant	267	1	R → H. Corresponds to variant rs11574483 [ dbSNP | Ensembl ].		VAR_049861
	Natural variant	279	1	A → T. Corresponds to variant rs10083681 [ dbSNP | Ensembl ].		VAR_049862
	Natural variant	315	1	P → L. Corresponds to variant rs7173448 [ dbSNP | Ensembl ].		VAR_049863
	Natural variant	329	1	R → S. Corresponds to variant rs7173476 [ dbSNP | Ensembl ].		VAR_049864
	Natural variant	378	1	T → M. Corresponds to variant rs11574479 [ dbSNP | Ensembl ].		VAR_049865
Experimental info
	Sequence conflict	387	1	R → Q in AAQ88709. Ref.3
	Sequence conflict	473	1	L → P in BAC11243. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (4Ig-B7-H3) [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 2181A064404C7939	FASTA	534	57,235
	10 20 30 40 50 60 MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC SFSPEPGFSL 70 80 90 100 110 120 AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF 130 140 150 160 170 180 TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE PNKDLRPGDT VTITCSSYQG YPEAEVFWQD 190 200 210 220 230 240 GQGVPLTGNV TTSQMANEQG LFDVHSILRV VLGANGTYSC LVRNPVLQQD AHSSVTITPQ 250 260 270 280 290 300 RSPTGAVEVQ VPEDPVVALV GTDATLRCSF SPEPGFSLAQ LNLIWQLTDT KQLVHSFTEG 310 320 330 340 350 360 RDQGSAYANR TALFPDLLAQ GNASLRLQRV RVADEGSFTC FVSIRDFGSA AVSLQVAAPY 370 380 390 400 410 420 SKPSMTLEPN KDLRPGDTVT ITCSSYRGYP EAEVFWQDGQ GVPLTGNVTT SQMANEQGLF 430 440 450 460 470 480 DVHSVLRVVL GANGTYSCLV RNPVLQQDAH GSVTITGQPM TFPPEALWVT VGLSVCLIAL 490 500 510 520 530 LVALAFVCWR KIKQSCEEEN AGAEDQDGEG EGSKTALQPL KHSDSKEDDG QEIA
	Isoform 2 (B7-H3) [UniParc]. Checksum: FF97007F191CCFA1	FASTA	316	33,791
	10 20 30 40 50 60 MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC SFSPEPGFSL 70 80 90 100 110 120 AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF 130 140 150 160 170 180 TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE PNKDLRPGDT VTITCSSYRG YPEAEVFWQD 190 200 210 220 230 240 GQGVPLTGNV TTSQMANEQG LFDVHSVLRV VLGANGTYSC LVRNPVLQQD AHGSVTITGQ 250 260 270 280 290 300 PMTFPPEALW VTVGLSVCLI ALLVALAFVC WRKIKQSCEE ENAGAEDQDG EGEGSKTALQ 310 PLKHSDSKED DGQEIA
	Isoform 3 [UniParc]. Checksum: CD7C5591CC4822D2	FASTA	493	52,761
	10 20 30 40 50 60 MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC SFSPEPGFSL 70 80 90 100 110 120 AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF 130 140 150 160 170 180 TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE PNKDLRPGDT VTITCSSYQG YPEAEVFWQD 190 200 210 220 230 240 GQGVPLTGNV TTSQMANEQG LFDVHSILRV VLGANGTYSC LVRNPVLQQD AHSSVTITPQ 250 260 270 280 290 300 RSPTGAVEVQ VPEDPVVALV GTDATLRCSF SPEPGFSLAQ LNLIWQLTDT KQLVHSFTEG 310 320 330 340 350 360 RDQGSAYANR TALFPDLLAQ GNASLRLQRV RVADEGSFTC FVSIRDFGSA AVSLQVAAPY 370 380 390 400 410 420 SKPSMTLEPN KDLRPGDTVT ITCSSYRGYP EAEVFWQDGQ GVPLTGNVTT SQMANEQGLF 430 440 450 460 470 480 DVHSVLRVVL GANGTYSCLV RNPVLQQDAH GSVTITGQPM TFPPGPASSA VPLSPAHPPH 490 GSMCWSHWFS RGL
	Isoform 4 [UniParc]. Checksum: BC38033295EBE978	FASTA	533	57,165
	10 20 30 40 50 60 MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC SFSPEPGFSL 70 80 90 100 110 120 AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF 130 140 150 160 170 180 TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE PNKDLRPGDT VTITCSSYQG YPEAEVFWQD 190 200 210 220 230 240 GQGVPLTGNV TTSQMANEQG LFDVHSILRV VLGANGTYSC LVRNPVLQQD AHSSVTITPQ 250 260 270 280 290 300 RSPTGAVEVQ VPEDPVVALV GTDATLRCSF SPEPGFSLAQ LNLIWQLTDT KQLVHSFTEG 310 320 330 340 350 360 RDQGSAYANR TALFPDLLAQ GNASLRLQRV RVADEGSFTC FVSIRDFGSA AVSLQVAAPY 370 380 390 400 410 420 SKPSMTLEPN KDLRPGDTVT ITCSSYRGYP EAEVFWQDGQ GVPLTGNVTT SQMANEQGLF 430 440 450 460 470 480 DVHSVLRVVL GANGTYSCLV RNPVLQQDAH GSVTITGQPM TFPPEALWVT VGLSVCLIAL 490 500 510 520 530 LVALAFVCWR KIKQSCEEEN AGAEDQDGEG EGSKTALQPL KHSDSKEGKD TWA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production." Chapoval A.I., Ni J., Lau J.S., Wilcox R.A., Flies D.B., Liu D., Dong H., Sica G.L., Zhu G., Tamada K., Chen L. Nat. Immunol. 2:269-274(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, FUNCTION.
[2]	"Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains." Steinberger P., Majdic O., Derdak S.V., Pfistershammer K., Kirchberger S., Klauser C., Zlabinger G., Pickl W.F., Stockl J., Knapp W. J. Immunol. 172:2352-2359(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, INDUCTION.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-534 (ISOFORM 1), VARIANT MET-160.
[5]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-160.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Lung.
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-43.
[8]	"Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss." Ling V., Wu P.W., Spaulding V., Kieleczawa J., Luxenberg D., Carreno B.M., Collins M. Genomics 82:365-377(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, GENOMIC DOMAIN DUPLICATION.
[9]	"Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis." Castriconi R., Dondero A., Augugliaro R., Cantoni C., Carnemolla B., Sementa A.R., Negri F., Conte R., Corrias M.V., Moretta L., Moretta A., Bottino C. Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta." Petroff M.G., Kharatyan E., Torry D.S., Holets L. Am. J. Pathol. 167:465-473(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"Constitutive and inducible expression of B7 family of ligands by human airway epithelial cells." Kim J., Myers A.C., Chen L., Pardoll D.M., Truong-Tran Q.A., Lane A.P., McDyer J.F., Fortuno L., Schleimer R.P. Am. J. Respir. Cell Mol. Biol. 33:280-289(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[12]	"B7-H3: another molecule marker for Mo-DCs?" Zhang G.B., Dong Q.M., Xu Y., Yu G.H., Zhang X.G. Cell. Mol. Immunol. 2:307-311(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[13]	"B7-H3 promotes acute and chronic allograft rejection." Wang L., Fraser C.C., Kikly K., Wells A.D., Han R., Coyle A.J., Chen L., Hancock W.W. Eur. J. Immunol. 35:428-438(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[14]	"Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses." Hashiguchi M., Kobori H., Ritprajak P., Kamimura Y., Kozono H., Azuma M. Proc. Natl. Acad. Sci. U.S.A. 105:10495-10500(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TREML2.
[15]	Erratum Hashiguchi M., Kobori H., Ritprajak P., Kamimura Y., Kozono H., Azuma M. Proc. Natl. Acad. Sci. U.S.A. 105:14744-14744(2008)
[16]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-322 AND ASN-407, MASS SPECTROMETRY. Tissue: Liver.
[18]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF302102 mRNA. Translation: AAK15438.1. AJ583695 mRNA. Translation: CAE47548.1. AY358343 mRNA. Translation: AAQ88709.1. AK074849 mRNA. Translation: BAC11243.1. AK074997 mRNA. Translation: BAC11344.1. Different initiation. AK075549 mRNA. Translation: BAC11692.1. BC062581 mRNA. Translation: AAH62581.1.
IPI	IPI00019275. IPI00410488. IPI00441094. IPI00719044.
RefSeq	NP_001019907.1. NM_001024736.1. NP_079516.1. NM_025240.2.
UniGene	Hs.77873.
3D structure databases
ProteinModelPortal	Q5ZPR3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5ZPR3. 1 interaction.
MINT	MINT-5000152.
STRING	9606.ENSP00000320084.
PTM databases
PhosphoSite	Q5ZPR3.
Polymorphism databases
DMDM	74757248.
Proteomic databases
PaxDb	Q5ZPR3.
PRIDE	Q5ZPR3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318424; ENSP00000320058; ENSG00000103855. ENST00000318443; ENSP00000320084; ENSG00000103855. ENST00000537340; ENSP00000441087; ENSG00000103855. ENST00000561213; ENSP00000452736; ENSG00000103855. ENST00000564751; ENSP00000454940; ENSG00000103855.
GeneID	80381.
KEGG	hsa:80381.
UCSC	uc002avu.1. human. uc002avv.1. human. uc002avw.1. human.
Organism-specific databases
CTD	80381.
GeneCards	GC15P073976.
HGNC	HGNC:19137. CD276.
HPA	CAB017826. HPA009285. HPA017139.
MIM	605715. gene.
neXtProt	NX_Q5ZPR3.
PharmGKB	PA142672148.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85729.
HOVERGEN	HBG079786.
InParanoid	Q5ZPR3.
KO	K06746.
OMA	GALWFCL.
Gene expression databases
ArrayExpress	Q5ZPR3.
Bgee	Q5ZPR3.
CleanEx	HS_CD276.
Genevestigator	Q5ZPR3.
GermOnline	ENSG00000103855. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR013162. CD80_C2-set. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF08205. C2-set_2. 2 hits. PF07686. V-set. 2 hits. [Graphical view]
SMART	SM00409. IG. 3 hits. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80381.
NextBio	70980.
SOURCE	Search...

Entry information

Entry name

CD276_HUMAN

Accession

Primary (citable) accession number: Q5ZPR3
Secondary accession number(s): Q6P5Y4 , Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	November 23, 2004
Last modified:	May 29, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.