ID   Q5ZPJ1_HUMAN            Unreviewed;       112 AA.
AC   Q5ZPJ1;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   22-FEB-2023, entry version 92.
DE   SubName: Full=Bax protein {ECO:0000313|EMBL:CAE52909.1};
DE   Flags: Fragment;
GN   Name=BAX {ECO:0000313|EMBL:CAE52909.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAE52909.1};
RN   [1] {ECO:0000313|EMBL:CAE52909.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Skin {ECO:0000313|EMBL:CAE52909.1};
RA   Zuliani T.;
RT   "Dynamique des populations cellulaire de l'epiderme humain.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family.
CC       {ECO:0000256|ARBA:ARBA00009458}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ586909; CAE52909.1; -; mRNA.
DR   RefSeq; NP_001278359.1; NM_001291430.1.
DR   AlphaFoldDB; Q5ZPJ1; -.
DR   PeptideAtlas; Q5ZPJ1; -.
DR   DNASU; 581; -.
DR   GeneID; 581; -.
DR   CTD; 581; -.
DR   OrthoDB; 5385020at2759; -.
DR   BioGRID-ORCS; 581; 32 hits in 1176 CRISPR screens.
DR   ChiTaRS; BAX; human.
DR   GenomeRNAi; 581; -.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd06845; Bcl-2_like; 1.
DR   Gene3D; 1.10.437.10; Blc2-like; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR026298; Bcl-2_fam.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR   InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR   PANTHER; PTHR11256:SF42; APOPTOSIS REGULATOR BAX; 1.
DR   PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00337; BCL; 1.
DR   SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01080; BH1; 1.
DR   PROSITE; PS01258; BH2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703}.
FT   DOMAIN          1..80
FT                   /note="Bcl-2 Bcl-2 homology region 1-3"
FT                   /evidence="ECO:0000259|SMART:SM00337"
FT   REGION          90..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..112
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         112
FT                   /evidence="ECO:0000313|EMBL:CAE52909.1"
SQ   SEQUENCE   112 AA;  12608 MW;  4CD21BC9AEA1258B CRC64;
     MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK VPELIRTIMG
     WTLDFLRERL LGWIQDQGGW VRLLKPPHPH HRALTTAPAP PSLPPATPLG PW
//