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Q5ZPJ1

- Q5ZPJ1_HUMAN

UniProt

Q5ZPJ1 - Q5ZPJ1_HUMAN

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Protein
Submitted name: Bax protein
Gene
BAX
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. B cell apoptotic process Source: Ensembl
  2. B cell homeostasis Source: Ensembl
  3. B cell homeostatic proliferation Source: Ensembl
  4. B cell negative selection Source: Ensembl
  5. Sertoli cell proliferation Source: Ensembl
  6. T cell homeostatic proliferation Source: Ensembl
  7. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Ensembl
  8. activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
  9. apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
  10. apoptotic process involved in patterning of blood vessels Source: Ensembl
  11. blood vessel remodeling Source: Ensembl
  12. cellular response to UV Source: Ensembl
  13. cellular response to organic substance Source: Ensembl
  14. cerebral cortex development Source: Ensembl
  15. development of secondary sexual characteristics Source: Ensembl
  16. ectopic germ cell programmed cell death Source: Ensembl
  17. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  18. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  19. fertilization Source: Ensembl
  20. germ cell development Source: Ensembl
  21. glycosphingolipid metabolic process Source: Ensembl
  22. homeostasis of number of cells within a tissue Source: Ensembl
  23. hypothalamus development Source: Ensembl
  24. intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
  25. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  26. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
  27. kidney development Source: Ensembl
  28. myeloid cell homeostasis Source: Ensembl
  29. negative regulation of apoptotic signaling pathway Source: Ensembl
  30. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
  31. negative regulation of fibroblast proliferation Source: Ensembl
  32. negative regulation of neuron apoptotic process Source: Ensembl
  33. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  34. neuron apoptotic process Source: Ensembl
  35. neuron migration Source: Ensembl
  36. nuclear fragmentation involved in apoptotic nuclear change Source: Ensembl
  37. odontogenesis of dentin-containing tooth Source: Ensembl
  38. ovarian follicle development Source: Ensembl
  39. positive regulation of B cell apoptotic process Source: Ensembl
  40. positive regulation of apoptotic process involved in mammary gland involution Source: Ensembl
  41. positive regulation of developmental pigmentation Source: Ensembl
  42. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  43. positive regulation of neuron apoptotic process Source: Ensembl
  44. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  45. post-embryonic camera-type eye morphogenesis Source: Ensembl
  46. protein homooligomerization Source: Ensembl
  47. protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Ensembl
  48. regulation of cell cycle Source: Ensembl
  49. regulation of mammary gland epithelial cell proliferation Source: Ensembl
  50. regulation of nitrogen utilization Source: Ensembl
  51. release of cytochrome c from mitochondria Source: Ensembl
  52. response to acid Source: Ensembl
  53. response to axon injury Source: Ensembl
  54. response to gamma radiation Source: Ensembl
  55. response to salt stress Source: Ensembl
  56. response to toxic substance Source: Ensembl
  57. retina development in camera-type eye Source: Ensembl
  58. retinal cell programmed cell death Source: Ensembl
  59. spermatid differentiation Source: Ensembl
  60. thymocyte apoptotic process Source: Ensembl
  61. vagina development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Bax proteinImported
Gene namesi
Name:BAXImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endoplasmic reticulum Source: Ensembl
  3. mitochondrial outer membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ5ZPJ1.

Expressioni

Gene expression databases

ArrayExpressiQ5ZPJ1.
BgeeiQ5ZPJ1.

Structurei

3D structure databases

ProteinModelPortaliQ5ZPJ1.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000095178.

Family and domain databases

InterProiIPR026304. BAX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF8. PTHR11256:SF8. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5ZPJ1-1 [UniParc]FASTAAdd to Basket

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MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK    50
VPELIRTIMG WTLDFLRERL LGWIQDQGGW VRLLKPPHPH HRALTTAPAP 100
PSLPPATPLG PW 112
Length:112
Mass (Da):12,608
Last modified:November 23, 2004 - v1
Checksum:i4CD21BC9AEA1258B
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei112 – 1121Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ586909 mRNA. Translation: CAE52909.1.
RefSeqiNP_001278359.1. NM_001291430.1.
UniGeneiHs.624291.

Genome annotation databases

GeneIDi581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ586909 mRNA. Translation: CAE52909.1 .
RefSeqi NP_001278359.1. NM_001291430.1.
UniGenei Hs.624291.

3D structure databases

ProteinModelPortali Q5ZPJ1.
ModBasei Search...

Proteomic databases

PRIDEi Q5ZPJ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 581.

Phylogenomic databases

HOGENOMi HOG000095178.

Miscellaneous databases

ChiTaRSi BAX. human.

Gene expression databases

ArrayExpressi Q5ZPJ1.
Bgeei Q5ZPJ1.

Family and domain databases

InterProi IPR026304. BAX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view ]
PANTHERi PTHR11256. PTHR11256. 1 hit.
PTHR11256:SF8. PTHR11256:SF8. 1 hit.
Pfami PF00452. Bcl-2. 1 hit.
[Graphical view ]
PRINTSi PR01862. BCL2FAMILY.
PROSITEi PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dynamique des populations cellulaire de l'epiderme humain."
    Zuliani T.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SkinImported.

Entry informationi

Entry nameiQ5ZPJ1_HUMAN
AccessioniPrimary (citable) accession number: Q5ZPJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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