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Protein
Submitted name:

Bax protein

Gene

BAX

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Ensembl
  2. activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
  3. apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
  4. apoptotic process involved in patterning of blood vessels Source: Ensembl
  5. B cell apoptotic process Source: Ensembl
  6. B cell homeostasis Source: Ensembl
  7. B cell homeostatic proliferation Source: Ensembl
  8. B cell negative selection Source: Ensembl
  9. blood vessel remodeling Source: Ensembl
  10. cellular response to organic substance Source: Ensembl
  11. cellular response to UV Source: Ensembl
  12. cerebral cortex development Source: Ensembl
  13. development of secondary sexual characteristics Source: Ensembl
  14. ectopic germ cell programmed cell death Source: Ensembl
  15. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  16. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  17. fertilization Source: Ensembl
  18. germ cell development Source: Ensembl
  19. glycosphingolipid metabolic process Source: Ensembl
  20. homeostasis of number of cells within a tissue Source: Ensembl
  21. hypothalamus development Source: Ensembl
  22. intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
  23. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  24. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
  25. kidney development Source: Ensembl
  26. mitochondrion morphogenesis Source: Ensembl
  27. myeloid cell homeostasis Source: Ensembl
  28. negative regulation of apoptotic signaling pathway Source: Ensembl
  29. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
  30. negative regulation of fibroblast proliferation Source: Ensembl
  31. negative regulation of neuron apoptotic process Source: Ensembl
  32. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  33. neuron apoptotic process Source: Ensembl
  34. neuron migration Source: Ensembl
  35. odontogenesis of dentin-containing tooth Source: Ensembl
  36. ovarian follicle development Source: Ensembl
  37. positive regulation of apoptotic process involved in mammary gland involution Source: Ensembl
  38. positive regulation of B cell apoptotic process Source: Ensembl
  39. positive regulation of developmental pigmentation Source: Ensembl
  40. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  41. positive regulation of neuron apoptotic process Source: Ensembl
  42. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  43. post-embryonic camera-type eye morphogenesis Source: Ensembl
  44. protein homooligomerization Source: Ensembl
  45. protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Ensembl
  46. regulation of cell cycle Source: Ensembl
  47. regulation of mammary gland epithelial cell proliferation Source: Ensembl
  48. regulation of mitochondrial membrane permeability involved in programmed necrotic cell death Source: Ensembl
  49. regulation of nitrogen utilization Source: Ensembl
  50. release of cytochrome c from mitochondria Source: Ensembl
  51. response to axon injury Source: Ensembl
  52. response to gamma radiation Source: Ensembl
  53. response to salt stress Source: Ensembl
  54. response to toxic substance Source: Ensembl
  55. retina development in camera-type eye Source: Ensembl
  56. retinal cell programmed cell death Source: Ensembl
  57. Sertoli cell proliferation Source: Ensembl
  58. spermatid differentiation Source: Ensembl
  59. T cell homeostatic proliferation Source: Ensembl
  60. thymocyte apoptotic process Source: Ensembl
  61. vagina development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Bax proteinImported
Gene namesi
Name:BAXImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endoplasmic reticulum Source: Ensembl
  3. mitochondrial outer membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ5ZPJ1.

Expressioni

Gene expression databases

BgeeiQ5ZPJ1.
ExpressionAtlasiQ5ZPJ1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5ZPJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000095178.
KOiK02159.

Family and domain databases

InterProiIPR026304. BAX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF8. PTHR11256:SF8. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5ZPJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK
60 70 80 90 100
VPELIRTIMG WTLDFLRERL LGWIQDQGGW VRLLKPPHPH HRALTTAPAP
110
PSLPPATPLG PW
Length:112
Mass (Da):12,608
Last modified:November 23, 2004 - v1
Checksum:i4CD21BC9AEA1258B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei112 – 1121Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ586909 mRNA. Translation: CAE52909.1.
RefSeqiNP_001278359.1. NM_001291430.1.
UniGeneiHs.624291.

Genome annotation databases

GeneIDi581.
KEGGihsa:581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ586909 mRNA. Translation: CAE52909.1.
RefSeqiNP_001278359.1. NM_001291430.1.
UniGeneiHs.624291.

3D structure databases

ProteinModelPortaliQ5ZPJ1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5ZPJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi581.
KEGGihsa:581.

Organism-specific databases

CTDi581.

Phylogenomic databases

HOGENOMiHOG000095178.
KOiK02159.

Miscellaneous databases

ChiTaRSiBAX. human.

Gene expression databases

BgeeiQ5ZPJ1.
ExpressionAtlasiQ5ZPJ1. baseline and differential.

Family and domain databases

InterProiIPR026304. BAX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF8. PTHR11256:SF8. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Dynamique des populations cellulaire de l'epiderme humain."
    Zuliani T.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SkinImported.

Entry informationi

Entry nameiQ5ZPJ1_HUMAN
AccessioniPrimary (citable) accession number: Q5ZPJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.