Rho GTPase-activating protein 26 - Gallus gallus (Chicken)

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Q5ZMW5 (RHG26_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Rho GTPase-activating protein 26

Alternative name(s):
GTPase regulator associated with focal adhesion kinase
Rho-type GTPase-activating protein 26

Gene names

Name:	ARHGAP26
Synonyms:	GRAF

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	760 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTPase-activating protein for RHOA and CDC42. Ref.2 Ref.3
Subunit structure	Binds to the C-terminus of PTK2/FAK1. Ref.2
Subcellular location	Cell junction › focal adhesion. Cytoplasm › cytoskeleton. Note: Colocalizes with actin stress fibers and cortical actin structures. Ref.2
Tissue specificity	Detected in embryonic brain and liver, and at low levels in embryonic eye, heart, lung, intestine and skeletal muscle. Ref.2
Sequence similarities	Contains 1 PH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain.
Sequence caution	The sequence AAB07998.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasm Cytoskeleton
Domain	SH3 domain
Molecular function	GTPase activation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	filopodium assembly Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell focal adhesion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW SH3 domain binding Inferred from electronic annotation. Source: InterPro cytoskeletal adaptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 760

760

Rho GTPase-activating protein 26

PRO_0000355552

Regions

Domain

265 – 369

105

Domain

383 – 568

186

Rho-GAP

Domain

702 – 760

SH3

Experimental info

Sequence conflict

196

F → S in CAG30928. Ref.1

Secondary structure

760

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q5ZMW5 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: DE3E2F3D4ED56667
Show »

FASTA

760

86,524

        10         20         30         40         50         60 
MGLPALEFSE CCLDSPQFRE RLRSHEAELE KTNKFIKELI KDGKSLIAAL KNLSSAKRKF 

        70         80         90        100        110        120 
ADSLNEFKFR CIGDAETDDE ICIAKSLQEF ATVLRNLEDE RMRMIENASE VLITPLEKFR 

       130        140        150        160        170        180 
KEQIGAAKDA KKKYDKETEK YCGVLEKHLN LSSKKKESQL QEADSQVDLV RQHFYEVSLE 

       190        200        210        220        230        240 
YVFKVQEVQE RKMFEFVEPL LAFLQGLFTF YHHGYELAKD FSDFKTELTI SIQNTRNRFE 

       250        260        270        280        290        300 
GTRSEVESLM KKMKENPHEH KNISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRESKRITM 

       310        320        330        340        350        360 
VPFDQKSGGK GGEDEAVILK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ ALSEEDRRLW 

       370        380        390        400        410        420 
MEAMDGREPV YNSNKDNQSE GTAQLDSIGF SIIKKCIHAV ETRGINEQGL YRIVGVNSRV 

       430        440        450        460        470        480 
QKLLSILMDP KTATETETEI CAEWEIKTIT SALKTYLRML PGPLMMYQFQ RSFIKAAKLE 

       490        500        510        520        530        540 
NQESRVSEIH SLVHRLPEKN RQMLHLLMNH LAKVADNHKQ NLMTVANLGV VFGPTLLRPQ 

       550        560        570        580        590        600 
EETVAAIMDI KFQNIVIEIL IENHEKIFNT VPETPPSNSQ LLLSRKKSTD SKPPSCSERP 

       610        620        630        640        650        660 
LTLFHTAQPN EKQESRNSII NSSLESVISS NANSFLNSNS APQSNLNSSD LELEVIKPNR 

       670        680        690        700        710        720 
PNSLPQNPSP TSPLSPSWPM FSAPSSPMPT SSTSSDSSPI SSPLRKARAL YACKAEHDSE 

       730        740        750        760 
LSFTAGTVFD NVHPSQEPGW LEGTLNGKTG LIPENYVEFL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.
[2]	"An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase." Hildebrand J.D., Taylor J.M., Parsons J.T. Mol. Cell. Biol. 16:3169-3178(1996) [PubMed: 8649427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 177-760, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PTK2/FAK1, TISSUE SPECIFICITY. Tissue: Embryo.
[3]	"Structure of the BH domain from Graf and its implications for Rho GTPase recognition." Longenecker K.L., Zhang B., Derewenda U., Sheffield P.J., Dauter Z., Parsons J.T., Zheng Y., Derewenda Z.S. J. Biol. Chem. 275:38605-38610(2000) [PubMed: 10982819] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 161-391, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ719269 mRNA. Translation: CAG30928.1.
U36309 mRNA. Translation: AAB07998.1. Different initiation.

IPI

IPI00596193.

RefSeq

NP_990525.1. NM_205194.1.

UniGene

Gga.2901.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1F7C	X-ray	2.40	A	353-583	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

Q5ZMW5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

396113.

KEGG

gga:396113.

Organism-specific databases

CTD

23092.

Phylogenomic databases

eggNOG

veNOG07334.

GeneTree

ENSGT00600000084123.

HOVERGEN

HBG067993.

OrthoDB

EOG4XGZZP.

Family and domain databases

InterPro

IPR013606. IRSp53/MIM_homology_IMD.
IPR011993. PH_type.
IPR001849. Pleckstrin_homology.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]

Gene3D

G3DSA:1.20.1270.80. IRSp53/MIM_homology_IMD. 1 hit.
G3DSA:2.30.29.30. PH_type. 1 hit.
G3DSA:1.10.555.10. RhoGAP. 1 hit.

Pfam

PF08397. IMD. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]

SMART

SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF48350. Rho_GAP. 1 hit.
SSF50044. SH3. 1 hit.

PROSITE

PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

RHG26_CHICK

Accession

Primary (citable) accession number: Q5ZMW5
Secondary accession number(s): Q98935

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	December 16, 2008
Last modified:	January 25, 2012
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents