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Protein

Rho GTPase-activating protein 26

Gene

ARHGAP26

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein for RHOA and CDC42.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-GGA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 26
Alternative name(s):
GTPase regulator associated with focal adhesion kinase
Rho-type GTPase-activating protein 26
Gene namesi
Name:ARHGAP26
Synonyms:GRAF
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

  • Cell junctionfocal adhesion 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: Colocalizes with actin stress fibers and cortical actin structures.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Rho GTPase-activating protein 26PRO_0000355552Add
BLAST

Proteomic databases

PaxDbiQ5ZMW5.

Expressioni

Tissue specificityi

Detected in embryonic brain and liver, and at low levels in embryonic eye, heart, lung, intestine and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSGALG00000007380.

Interactioni

Subunit structurei

Binds to the C-terminus of PTK2/FAK1.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011921.

Structurei

Secondary structure

1
760
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi387 – 40317Combined sources
Turni408 – 4125Combined sources
Helixi417 – 42812Combined sources
Helixi446 – 45813Combined sources
Beta strandi460 – 4623Combined sources
Helixi467 – 47711Combined sources
Helixi482 – 49312Combined sources
Helixi498 – 51619Combined sources
Helixi518 – 5214Combined sources
Helixi525 – 53612Combined sources
Helixi546 – 5494Combined sources
Helixi550 – 56213Combined sources
Helixi564 – 5696Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F7CX-ray2.40A353-583[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5ZMW5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini265 – 369105PHPROSITE-ProRule annotationAdd
BLAST
Domaini383 – 568186Rho-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini702 – 76059SH3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG1451. Eukaryota.
ENOG410YJPS. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000018767.
HOVERGENiHBG067993.
InParanoidiQ5ZMW5.
KOiK20071.
OMAiKDFGDFK.
OrthoDBiEOG091G01TT.
PhylomeDBiQ5ZMW5.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR030061. RHG26.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR12552:SF4. PTHR12552:SF4. 1 hit.
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZMW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPALEFSE CCLDSPQFRE RLRSHEAELE KTNKFIKELI KDGKSLIAAL
60 70 80 90 100
KNLSSAKRKF ADSLNEFKFR CIGDAETDDE ICIAKSLQEF ATVLRNLEDE
110 120 130 140 150
RMRMIENASE VLITPLEKFR KEQIGAAKDA KKKYDKETEK YCGVLEKHLN
160 170 180 190 200
LSSKKKESQL QEADSQVDLV RQHFYEVSLE YVFKVQEVQE RKMFEFVEPL
210 220 230 240 250
LAFLQGLFTF YHHGYELAKD FSDFKTELTI SIQNTRNRFE GTRSEVESLM
260 270 280 290 300
KKMKENPHEH KNISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRESKRITM
310 320 330 340 350
VPFDQKSGGK GGEDEAVILK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ
360 370 380 390 400
ALSEEDRRLW MEAMDGREPV YNSNKDNQSE GTAQLDSIGF SIIKKCIHAV
410 420 430 440 450
ETRGINEQGL YRIVGVNSRV QKLLSILMDP KTATETETEI CAEWEIKTIT
460 470 480 490 500
SALKTYLRML PGPLMMYQFQ RSFIKAAKLE NQESRVSEIH SLVHRLPEKN
510 520 530 540 550
RQMLHLLMNH LAKVADNHKQ NLMTVANLGV VFGPTLLRPQ EETVAAIMDI
560 570 580 590 600
KFQNIVIEIL IENHEKIFNT VPETPPSNSQ LLLSRKKSTD SKPPSCSERP
610 620 630 640 650
LTLFHTAQPN EKQESRNSII NSSLESVISS NANSFLNSNS APQSNLNSSD
660 670 680 690 700
LELEVIKPNR PNSLPQNPSP TSPLSPSWPM FSAPSSPMPT SSTSSDSSPI
710 720 730 740 750
SSPLRKARAL YACKAEHDSE LSFTAGTVFD NVHPSQEPGW LEGTLNGKTG
760
LIPENYVEFL
Length:760
Mass (Da):86,524
Last modified:December 16, 2008 - v2
Checksum:iDE3E2F3D4ED56667
GO

Sequence cautioni

The sequence AAB07998 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961F → S in CAG30928 (PubMed:15642098).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719269 mRNA. Translation: CAG30928.1.
U36309 mRNA. Translation: AAB07998.1. Different initiation.
RefSeqiNP_990525.2. NM_205194.2.
UniGeneiGga.48270.

Genome annotation databases

EnsembliENSGALT00000011935; ENSGALP00000011921; ENSGALG00000007380.
GeneIDi396113.
KEGGigga:396113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719269 mRNA. Translation: CAG30928.1.
U36309 mRNA. Translation: AAB07998.1. Different initiation.
RefSeqiNP_990525.2. NM_205194.2.
UniGeneiGga.48270.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F7CX-ray2.40A353-583[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011921.

Proteomic databases

PaxDbiQ5ZMW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000011935; ENSGALP00000011921; ENSGALG00000007380.
GeneIDi396113.
KEGGigga:396113.

Organism-specific databases

CTDi23092.

Phylogenomic databases

eggNOGiKOG1451. Eukaryota.
ENOG410YJPS. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000018767.
HOVERGENiHBG067993.
InParanoidiQ5ZMW5.
KOiK20071.
OMAiKDFGDFK.
OrthoDBiEOG091G01TT.
PhylomeDBiQ5ZMW5.

Enzyme and pathway databases

ReactomeiR-GGA-194840. Rho GTPase cycle.

Miscellaneous databases

EvolutionaryTraceiQ5ZMW5.
PROiQ5ZMW5.

Gene expression databases

BgeeiENSGALG00000007380.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR030061. RHG26.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR12552:SF4. PTHR12552:SF4. 1 hit.
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHG26_CHICK
AccessioniPrimary (citable) accession number: Q5ZMW5
Secondary accession number(s): Q98935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.