Q5ZMT0 (1433E_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
14-3-3 protein epsilon
Short name=14-3-3E

Gene names

Name:	YWHAE
ORF Names:	RCJMB04_1e8

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Subunit structure	Homodimer, and heterodimer with other family members By similarity.
Subcellular location	Cytoplasm By similarity UniProtKB P62262.
Sequence similarities	Belongs to the 14-3-3 family.
Mass spectrometry	Molecular mass is 29440±2 Da from positions 1 - 255. Determined by MALDI. Ref.2

Ontologies

Keywords
Cellular component	Cytoplasm
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	14-3-3 protein epsilon		PRO_0000223506
Sites
	Site	57	1	Interaction with phosphoserine on interacting protein By similarity
	Site	130	1	Interaction with phosphoserine on interacting protein By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity UniProtKB P62262

Sequences

	Sequence		Length	Mass (Da)
	Q5ZMT0 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 07817CCBD1F75B26	FASTA	255	29,174
	10 20 30 40 50 60 MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW 70 80 90 100 110 120 RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF 130 140 150 160 170 180 YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF 190 200 210 220 230 240 YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE 250 EQNKEALQDV EDENQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.
[2]	"Proteomic analysis of the Gallus gallus embryo at stage-29 of development." Agudo D., Gomez-Esquer F., Diaz-Gil G., Martinez-Arribas F., Delcan J., Schneider J., Palomar M.A., Linares R. Proteomics 5:4946-4957(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, MASS SPECTROMETRY. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ719304 mRNA. Translation: CAG30963.1.
IPI	IPI00579092.
RefSeq	NP_001006219.1. NM_001006219.1.
UniGene	Gga.4550.
3D structure databases
ProteinModelPortal	Q5ZMT0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5ZMT0. 1 interaction.
STRING	9031.ENSGALP00000004182.
Proteomic databases
PaxDb	Q5ZMT0.
PRIDE	Q5ZMT0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	417554.
KEGG	gga:417554.
Organism-specific databases
CTD	7531.
Phylogenomic databases
eggNOG	COG5040.
HOGENOM	HOG000240379.
HOVERGEN	HBG050423.
InParanoid	Q5ZMT0.
KO	K06630.
OrthoDB	EOG4HHP34.
Family and domain databases
Gene3D	1.20.190.20. 1 hit.
InterPro	IPR000308. 14-3-3. IPR023409. 14-3-3_CS. IPR023410. 14-3-3_domain. [Graphical view]
PANTHER	PTHR18860. PTHR18860. 1 hit.
Pfam	PF00244. 14-3-3. 1 hit. [Graphical view]
PIRSF	PIRSF000868. 14-3-3. 1 hit.
PRINTS	PR00305. 1433ZETA.
SMART	SM00101. 14_3_3. 1 hit. [Graphical view]
SUPFAM	SSF48445. 14-3-3. 1 hit.
PROSITE	PS00796. 1433_1. 1 hit. PS00797. 1433_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20820839.

Entry information

Entry name

1433E_CHICK

Accession

Primary (citable) accession number: Q5ZMT0
Secondary accession number(s): P84171

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program