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Protein

Platelet-activating factor acetylhydrolase IB subunit beta

Gene

PAFAH1B2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inactivates PAF by removing the acetyl group at the sn-2 position.By similarity

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei48 – 481By similarity
Active sitei193 – 1931By similarity
Active sitei196 – 1961By similarity

GO - Molecular functioni

  1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase IB subunit beta (EC:3.1.1.47)
Alternative name(s):
PAF acetylhydrolase 30 kDa subunit
Short name:
PAF-AH 30 kDa subunit
PAF-AH subunit beta
PAFAH subunit beta
Gene namesi
Name:PAFAH1B2
Synonyms:PAFAHB
ORF Names:RCJMB04_1f10
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Platelet-activating factor acetylhydrolase IB subunit betaPRO_0000252684Add
BLAST

Proteomic databases

PaxDbiQ5ZMS2.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011588.

Structurei

3D structure databases

ProteinModelPortaliQ5ZMS2.
SMRiQ5ZMS2. Positions 6-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG69837.
HOGENOMiHOG000232143.
HOVERGENiHBG053477.
InParanoidiQ5ZMS2.
PhylomeDBiQ5ZMS2.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZMS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGDSNPAA VPHAADDIQG DDRWMSQHNR FVSDCKDKEP DVLFVGDSMV
60 70 80 90 100
QLLQQYEIWR ELFSPLHALN FWIGGDTTGH VLWRLKNGEL ENIKPKVIVV
110 120 130 140 150
WVGTNNYGNT AEEVAGGIEA IVRLINTQQP QAKVIVLGLL PRGEKPNPLR
160 170 180 190 200
QKNAKVNHLL KASLPKLPNV QLLDVDAGFV HSDGTISYHD MFDFLHLTGG
210 220
AYAKICKPLH ELIMQLLEET PEEKRAALA
Length:229
Mass (Da):25,567
Last modified:November 22, 2004 - v1
Checksum:i27AEDEAA33C4B130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719312 mRNA. Translation: CAG30971.1.
UniGeneiGga.17363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719312 mRNA. Translation: CAG30971.1.
UniGeneiGga.17363.

3D structure databases

ProteinModelPortaliQ5ZMS2.
SMRiQ5ZMS2. Positions 6-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011588.

Proteomic databases

PaxDbiQ5ZMS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG69837.
HOGENOMiHOG000232143.
HOVERGENiHBG053477.
InParanoidiQ5ZMS2.
PhylomeDBiQ5ZMS2.

Miscellaneous databases

NextBioi20822772.
PROiQ5ZMS2.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiPA1B2_CHICK
AccessioniPrimary (citable) accession number: Q5ZMS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 16, 2006
Last sequence update: November 22, 2004
Last modified: March 31, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.