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Q5ZMS2 (PA1B2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Platelet-activating factor acetylhydrolase IB subunit beta

EC=3.1.1.47
Alternative name(s):
PAF acetylhydrolase 30 kDa subunit
Short name=PAF-AH 30 kDa subunit
PAF-AH subunit beta
PAFAH subunit beta
Gene names
Name:PAFAH1B2
Synonyms:PAFAHB
ORF Names:RCJMB04_1f10
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inactivates PAF by removing the acetyl group at the sn-2 position By similarity.

Catalytic activity

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Platelet-activating factor acetylhydrolase IB subunit beta
PRO_0000252684

Sites

Active site481 By similarity
Active site1931 By similarity
Active site1961 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZMS2 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 27AEDEAA33C4B130

FASTA22925,567
        10         20         30         40         50         60 
MSHGDSNPAA VPHAADDIQG DDRWMSQHNR FVSDCKDKEP DVLFVGDSMV QLLQQYEIWR 

        70         80         90        100        110        120 
ELFSPLHALN FWIGGDTTGH VLWRLKNGEL ENIKPKVIVV WVGTNNYGNT AEEVAGGIEA 

       130        140        150        160        170        180 
IVRLINTQQP QAKVIVLGLL PRGEKPNPLR QKNAKVNHLL KASLPKLPNV QLLDVDAGFV 

       190        200        210        220 
HSDGTISYHD MFDFLHLTGG AYAKICKPLH ELIMQLLEET PEEKRAALA 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ719312 mRNA. Translation: CAG30971.1.
UniGeneGga.17363.

3D structure databases

ProteinModelPortalQ5ZMS2.
SMRQ5ZMS2. Positions 6-223.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000011588.

Proteomic databases

PaxDbQ5ZMS2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG69837.
HOGENOMHOG000232143.
HOVERGENHBG053477.
InParanoidQ5ZMS2.
PhylomeDBQ5ZMS2.

Family and domain databases

Gene3D3.40.50.1110. 1 hit.
InterProIPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]
ProtoNetSearch...

Other

NextBio20822772.
PROQ5ZMS2.

Entry information

Entry namePA1B2_CHICK
AccessionPrimary (citable) accession number: Q5ZMS2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families